Analysis Ofsome Components of Blood Proteome in “Healthy Population” of Russian Megapolis

Abstract

The aim of the study was to study some components of blood proteome in healthy megapolis population. Methods: The study included 2025 people examined in the framework of preventive medical examination and referred to its results to 1–2 groups of health (the category of healthy people) and did not have at the time of examination of chronic and acute diseases. The age of the examined persons was in the range of 20–50 years (median — 34.8 years). Total protein level, plasma concentrations of C-reactive protein, ferritin and homocysteine were selected as markers of blood proteome. Results: Our screening study allowed establishing that a significant part of the population of the megapolis, classified as practically healthy persons, has deviations from the physiological interval for a number of proteome components. This is most evident in shifts in plasma concentrations of C-reactive protein and ferritin. So, in more than half of the individuals levels of C-reactive protein was outside the normal range. The distribution structure for ferritin shows the opposite trend