Analysis of Vascular Endothelial Growth Factor (VEGF) Functional Variants in Rheumatoid Arthritis

Rueda, Blanca; Ma, Genshan; López-Nevot, Miguel-Ángel; Delgado, Antonio; Fernández‐Arquero, Miguel; Balsa, Alejandro; Pablos, José L.; Pascual‐Salcedo, Dora; Concha, Emilio G. de la; González-Escribano, Marı́a-Francisca; Martı́n, Javier

doi:10.1016/j.humimm.2005.05.004

Cited by 32 publications

(37 citation statements)

References 20 publications

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“…23 Both hypoxia and VEGF may aggravate tissue injury by increase in vascular permeability and acceleration of the inflammatory process, which may be crucial in the initiation of RA. 12 …”

Section: Discussionmentioning

confidence: 99%

“…Two promoter polymorphisms of VEGF have been investigated in a Spanish population and may not play a relevant role in RA pathogenesis in Spanish population. 12 Intriguingly, Han et al 13 investigated the same 2 polymorphisms and 2 additional ones in Korean population, and their data suggested that VEGF gene might may play a role in the development of RA. It was indicated that the association of VEGF SNPs with RA might depend on racial background, and genetic susceptibility to RA might be different in different populations.…”

Section: Introductionmentioning

confidence: 99%

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Vascular Endothelial Growth Factor Gene Polymorphisms and Rheumatoid Arthritis

Lin

Xia

et al. 2011

Journal of Investigative Medicine

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“…23 Both hypoxia and VEGF may aggravate tissue injury by increase in vascular permeability and acceleration of the inflammatory process, which may be crucial in the initiation of RA. 12 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vascular Endothelial Growth Factor Gene Polymorphisms and Rheumatoid Arthritis

Lin

Xia

et al. 2011

Journal of Investigative Medicine

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“…In recent years, global research has demonstrated that various VEGF polymorphisms may be associated with the risk of developing various diseases including inflammation, heart disease, kidney disease, recurrent spontaneous abortion, and diabetes (Awata et al, 2002;Coulam et al, 2008;Reiterová et al 2008;Rueda et al, 2005;Xie et al, 2007). In particular, VEGF genes, as a major genetic factor, have affected severe development of cancer by the so-called angiogenesis from tumor cell (Folkman et al, 1992;Harry et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Association of the vascular endothelial growth factor (VEGF-1154G>A) polymorphism in patients with colorectal cancer

Choi

Kim

et al. 2011

Genes Genom

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Angiogenesis plays a pivotal role in the development of colon cancer during the promotion and metastasis of tumor growth. Vascular endothelial growth factor (VEGF) is known to be a potent angiogenic factor. This hospital-based case-control study was carried out to decide where there existed an association between the VEGF -1154G>A polymorphism and the susceptibility to colon cancer. DNA samples taken from 278 colon cancer patients and 226 healthy controls were studied using with real-time PCR for VEGF -1154G>A polymorphism. Genotype frequencies of the VEGF -1154G>A polymorphism were significantly different between patient and control groups (adjusted OR=2.735, 95% CI=1.243-6.015 for AA vs. GG genotype). In addition, upon stratification by gender and age, the frequencies of the A allele-bearing genotypes significantly increased the risk for development of colon cancer in men and patients younger than 55 years (in men, adjusted OR=3.375, The first two authors, YSC and JKC, contributed equally to this work. , and in <55 years, adjusted OR=4.908, 95% CI=1.294-18.617). Also, upon stratification of patients with proximal and distal colon cancer individually, the association only showed these significant patterns in distal colon cancer. This study provides evidence that VEGF -1154G>A polymorphism, at least in Koreans, might be associated with risks of the colon cancer, particularly in males.

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“…The studies scored from 0 to 40, based on 40 assessment items. The eligible studies were divided into three levels accordingly: low quality (0-19), moderate quality (20)(21)(22)(23)(24)(25)(26)(27)(28)(29), and high quality (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40).…”

Section: Quality Assessmentmentioning

confidence: 99%

“…As for the detecting method of the VEGF +405G>C polymorphism, 19 studies used the classic method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), four used the MassARRAY method, and the other four chose the TaqMan method. According to the classification criteria of IMIDs, there were six studies focusing on psoriasis [13,[22][23][24][25][26], four on RA [27][28][29][30], four on KD [31][32][33][34], three on GCA [35][36][37], two on T1DM [38,39], two on BD [40,41], two on SLE [42,43], one on systemic sclerosis (SS) [44], one on psoriatic arthritis (PsA) [45], one on Graves' disease (GD) [14], and one on inflammatory bowel disease (IBD) [46]. Table 2 summarizes the meta-analysis results about the relationship between the VEGF +405G>C polymorphism and the risk of IMIDs.…”

Section: Main Characteristics Of Included Studiesmentioning

confidence: 99%

Polymorphism of VEGF gene in susceptibility to chronic immune-mediated inflammatory diseases: a meta-analysis

Chen

Xue³

et al. 2015

Rheumatol Int

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Background Vascular endothelial growth factor (VEGF) is an important angiogenic factor and may be connected with chronic immune-mediated inflammatory diseases (IMIDs) to some extent. However, previous researches about the relationship between the +405G>C (dbSNP: rs2010963) polymorphism in VEGF gene and the risk of IMIDs are controversial and inconsistent. So we conducted this meta-analysis to assess whether the relationship between the +405G>C polymorphism in the 5'-UTR region of VEGF gene and IMID susceptibility exists. Methods Our literature search was conducted on the PubMed, Embase, Web of science, Chinese National Knowledge Infrastructure, and Chinese Biomedical databases to retrieve for eligible studies. Odds ratios as well as their 95 % confidence intervals were utilized to deduce the possible relationship. Results A total number of 5175 patients with IMIDs and 7069 healthy controls from 27 case-control studies were included. For the overall eligible data collected in our meta-analysis, there was no marked relationship between +405G>C polymorphism and the risk of IMIDs. However, subgroup analysis by ethnicity suggested that +405C allele could be a protective factor for IMIDs in Asians, whereas an opposite conclusion was drawn in Caucasians. Conclusion Thus, we may come to the conclusion that the VEGF +405G>C polymorphism could be associated with IMIDs, and the correlation might vary with ethnic groups.

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Analysis of Vascular Endothelial Growth Factor (VEGF) Functional Variants in Rheumatoid Arthritis

Cited by 32 publications

References 20 publications

Vascular Endothelial Growth Factor Gene Polymorphisms and Rheumatoid Arthritis

Vascular Endothelial Growth Factor Gene Polymorphisms and Rheumatoid Arthritis

Association of the vascular endothelial growth factor (VEGF-1154G>A) polymorphism in patients with colorectal cancer

Polymorphism of VEGF gene in susceptibility to chronic immune-mediated inflammatory diseases: a meta-analysis

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