Association of the vascular endothelial growth factor (VEGF-1154G>A) polymorphism in patients with colorectal cancer

Abstract

Angiogenesis plays a pivotal role in the development of colon cancer during the promotion and metastasis of tumor growth. Vascular endothelial growth factor (VEGF) is known to be a potent angiogenic factor. This hospital-based case-control study was carried out to decide where there existed an association between the VEGF -1154G>A polymorphism and the susceptibility to colon cancer. DNA samples taken from 278 colon cancer patients and 226 healthy controls were studied using with real-time PCR for VEGF -1154G>A polymorphism. Genotype frequencies of the VEGF -1154G>A polymorphism were significantly different between patient and control groups (adjusted OR=2.735, 95% CI=1.243-6.015 for AA vs. GG genotype). In addition, upon stratification by gender and age, the frequencies of the A allele-bearing genotypes significantly increased the risk for development of colon cancer in men and patients younger than 55 years (in men, adjusted OR=3.375, The first two authors, YSC and JKC, contributed equally to this work. , and in <55 years, adjusted OR=4.908, 95% CI=1.294-18.617). Also, upon stratification of patients with proximal and distal colon cancer individually, the association only showed these significant patterns in distal colon cancer. This study provides evidence that VEGF -1154G>A polymorphism, at least in Koreans, might be associated with risks of the colon cancer, particularly in males.

Association of VEGF and KDR single nucleotide polymorphisms with colorectal cancer susceptibility in Koreans

“…Numerous studies have investigated the association between VEGF gene polymorphisms and CRC susceptibility, yet the results were inconsistent [18][19][20][21][22][23][24]. In the present study, the VEGF À2578C > A, À1154G > A, and À634G > C polymorphisms were not associated with the risk of CRC susceptibility in the Korean population.…”

“…In the present study, six well-known single nucleotide polymorphisms (SNPs) in the VEGF and KDR genes were identified by a database search. The VEGF À2578C > A, À1154G > A, À634G > C, and 936C > T SNPs have been described to be associated with altered VEGF expression levels [14][15][16][17] and investigated as surrogate markers of cancer susceptibility [18][19][20][21][22][23][24]. Additionally, KDR À604T > C and 1192G > A SNPs appear to be associated with the VEGF-KDR signaling pathway [25,26].…”

VEGF gene polymorphism interactions with dietary trace elements intake in determining the risk of metabolic syndrome

“…It was shown that intracellular zinc deprivation resulted in increased VEGF production by prostate cancer cells . Our results suggest that deficiency of some dietary factors may result in increased serum VEGF and more angiogenesis, affecting the transportation of essential nutrients to the body cells …”

“…Angiogenesis involves the construction of new capillaries from main blood vessels, and it is a pivotal mechanism for transporting essential nutrients into the cells. The VEGF gene contains several polymorphic regions known to influence VEGF expression . Angiogenesis and vasculogenesis are dependent on several growth factors and their associated tyrosine kinases.…”

Promoter polymorphisms of the vascular endothelial growth factor gene are associated with metabolic syndrome susceptibility in Koreans

“…The genotype and allele frequencies of the VEGF -2578C>A and -1154G>A polymorphisms may differ among populations. For example, the VEGF -2578C>A and -1154G>A polymorphism data differ among healthy populations (34)(35)(36)(37). The reported allele frequency of the VEGF -2578A allele was higher in white people (0.378 to 0.504) than in Brazilian black people (0.290) and Asians (0.276 to 0.280), including Chinese and Korean populations.…”