Analysis of the Risk Factors of Dengue Hemorrhagic Fever (DHF) In Rural Populations in Panongan Subdistrict, Tangerang 2016

Siregar, Deborah; Djadja, I Made; Arminsih, Ririn

doi:10.18502/kls.v4i1.1373

Cited by 3 publications

(7 citation statements)

References 2 publications

(2 reference statements)

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“…[19][20][21] Based on Malaysia's surveillance data, adult males had a 4.17 times greater risk of contracting dengue in contrast to females. 24,25 Our analysis revealed that the male and female ratio in dengue cases was 1.57:1, while in SD the ratio was increased to 4:1. The difference in gender was significant (p = 0.0005) and these were in agreement with other former studies.…”

Section: Discussionmentioning

confidence: 69%

“…22 Our findings indicate that older subjects were at high risk for SD as increased age is associated with the presence of comorbidities and altered level of immunity. 23,24 Males were reported to contract dengue more, in contrast to females. The percentage of males infected with dengue was higher in several studies ranging from 60.0% to 63.0%.…”

Section: Discussionmentioning

confidence: 99%

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The Roles of C-X-C Motif Chemokine Ligand 10 (CXCL10) in Dengue

Khamis¹,

Mokhtar²,

Wang³

et al. 2022

J. Pure Appl. Microbiol.

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Early diagnosis of dengue is crucial to prevent the progression to severe dengue (SD) leading to mortality rate reduction. This study aimed to determine the role of the CXCL10 in dengue and its potential utilization as one of the biomarkers for the early diagnosis of dengue. A case-control study was conducted involving healthy subjects as control (n = 10) and 193 subjects as dengue cases. The cases were categorized into dengue without warning signs (DwoWS: n = 70; 34.5 %), dengue with warning signs (DWWS: n = 108; 23.2 %), and severe dengue (SD: n = 15; 7.4 %). The socio-demographic characteristics, clinical presentations, and laboratory parameters (platelet and hematocrit) were documented. Serum CXCL10 quantification was performed using an enzyme-linked immunosorbent assay (ELISA). The descriptive analysis and Pearson’s correlation test were used to analyze demographic data and the correlation between CXCL10, hematocrit, and platelet respectively. The difference in age (p = 0.02) and ethnicity (p = 0.02) were significant between cases and control. Males more frequently had SD in contrast to females (4:1). The frequent warning signs were abdominal pain (42.0 %), severe vomiting (38.3 %), bleeding tendency (15.0 %), and fluid accumulation (7.2 %). The increase in hematocrit (p = 0.039) and platelet reduction (p = 0.0005) were significant in SD. The mean of CXCL10 in control (134.85 ± 48.52 rg/mL) was significantly lower than in cases (545.22 ± 76.33 rg/mL, p = 0.0005). The CXCL10 is evident to be a potential biomarker in the early diagnosis of dengue.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

The Roles of C-X-C Motif Chemokine Ligand 10 (CXCL10) in Dengue

Khamis¹,

Mokhtar²,

Wang³

et al. 2022

J. Pure Appl. Microbiol.

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“…The interaction between these factors and the use of K3EDTA anticoagulants could be the cause of no significant differences between NS1 (+) and NS1 (-). 11,14 The results of a differential count examination, especially the number of lymphocytes and basophils did not increase. Monocyte cell counts had a slight increase where on the NS1 (+) group monocyte count was 8.26% and NS1 (-) group was 8.76%.…”

Section: Resultsmentioning

confidence: 89%

“…Age is related to daily activities inside and outside because Aedes Sp has a biting habit in the morning and evening. 11 The results of different tests for the sex group and age between NS1 (+) and NS1 (-) showed that there were no significant differences. This happens because NS1 affects the severity of dengue disease but does not depend on the sex and age of the host.…”

Section: Resultsmentioning

confidence: 94%

“…There was a significant relationship between sex and dengue fever, where the results showed that men had a risk of 4.99 times higher than a woman. 11 Moreover, men have relatively higher work activities and mobilization than women. 12 Grouping characteristics by age, in the NS1 (+) group, was dominated by late adolescents (17-25 years), as many as 38.8% (19 people).…”

Section: Resultsmentioning

confidence: 99%

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Chymase level in dengue virus infection with or without positive Non-Structural 1(NS1)

Kasiyati¹,

Nugraha²,

Kahar³

2019

J. Teknol. Lab

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Thrombocytopenia, leukopenia, and monocytosis are laboratory parameters in the diagnosis of dengue virus infection. In addition to monocyte cells, mast cells also play a role in the innate immune response, where degranulation of mast cells will occur, which will secretion the active vaso mediator, Chymase. Chymase has a role in increasing vascular permeability resulting in plasma leakage in patients with dengue virus infection to determine the number of platelets, leukocytes, monocytes and chymase levels in patients with dengue infection in the acute phase. The platelet count mean in NS1 (+) was 132,140 cells / mm3 and the platelet count in the NS1 group was (-) 176,000 cells / mm3. The mean leukocytes NS1 (+) showed results of 4,350 cells / mm3 and NS1 (-) 5,250 cells / mm3. The mean monocyte NS1 (+) monocyte count was 8.26%, and NS1 (-) group was 8.76%. There were no significant differences in platelet counts, leukocytes and monocytes between NS1 (+) and NS1 (-) (P value> 0.05). The mean Chymase NS1 (+) 23.48, NS1 (-) 23.05 ng / mL and the control group 1.47ng / mL.

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Gambaran Nilai Hematokrit dan Jumlah Trombosit Pasien Demam Berdarah Dengue di RSUD Al-Ihsan Bandung

Sayyidah Fauziyah,

Wida Purbaningsih,

Annisa Rahmah Furqaani

2024

BCSMS

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Abstract.. Dengue fever (DHF) is a viral infectious disease transmitted by the Aedes aegypti mosquito and is characterized by fever, thrombocytopenia, and plasma permeation characterized by an increase in hematocrit. One of the important indicators of hematological examination to establish the diagnosis of DHF is platelet count and hematocrit value. This study aims to determine the description of hematocrit value and platelet count of DHF patients. The type of research used is descriptive analytic research using cross-sectional design with sample selection using purposive sampling technique. Data were taken from the medical records of DHF patients with a total sample of 175 patients. The results of the study obtained that the most age was children and adolescents, namely 64% and the most gender was female, namely 52%. Most patients had hematocrit values in the normal category, 73.1% with an average hematocrit value of 40.75%. Most patients had platelet counts <100,000/µL, 52.6% with an average platelet count of 120,880/µL. It can be concluded that the hematocrit value in patients is mostly in the normal level, and the platelet count is mostly in the <100,000/µL category. Abstrak. Demam Berdarah Dengue (DBD) merupakan penyakit infeksi virus yang ditularkan melalui nyamuk Aedes aegypti dan ditandai dengan adanya demam, trombositopenia, dan perembesan plasma yang ditandai dengan peningkatan hematokrit. Salah satu indikator penting pemeriksaan hematologi untuk menegakkan diagnosis DBD adalah jumlah trombosit dan nilai hematokrit. Penelitian ini bertujuan untuk mengetahui gambaran nilai hematokrit dan jumlah tombosit pasien DBD. Jenis penelitian yang digunakan adalah penelitian deskriptif analitik menggunakan rancangan cross-sectional dengan pemilihan sampel menggunakan teknik purposive sampling. Data diambil dari rekam medik pasien DBD dengan jumlah sampel 175 pasien. Hasil penelitian diperoleh umur terbanyak adalah anak dan remaja yaitu 64% dan jenis kelamin terbanyak adalah perempuan yaitu 52%. Sebagian besar pasien nilai hematokrit dalam kategori normal yaitu 73,1% dengan rata-rata nilai hematokrit adalah 40,75%. Sebagian besar pasien memiliki jumlah trombosit <100.000/µL yaitu 52,6% dengan rata-rata jumlah trombosit adalah 120.880/µL. Dapat disimpulkan bahwa nilai hematokrit pada pasien paling banyak dalam tingkatan normal, dan jumlah trombosit paling banyak dalam kategori <100.000/µL.

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Analysis of the Risk Factors of Dengue Hemorrhagic Fever (DHF) In Rural Populations in Panongan Subdistrict, Tangerang 2016

Cited by 3 publications

References 2 publications

The Roles of C-X-C Motif Chemokine Ligand 10 (CXCL10) in Dengue

The Roles of C-X-C Motif Chemokine Ligand 10 (CXCL10) in Dengue

Chymase level in dengue virus infection with or without positive Non-Structural 1(NS1)

Gambaran Nilai Hematokrit dan Jumlah Trombosit Pasien Demam Berdarah Dengue di RSUD Al-Ihsan Bandung

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