Analysis of the Prevalence of Sarcopenia and Its Risk Factors in the Elderly in the Chengdu Community

Chen, X.; Hou, Lisha; Zhang, Y.; Dong, Birong

doi:10.1007/s12603-020-1559-1

Cited by 24 publications

(53 citation statements)

References 17 publications

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“…This study assessed the prevalence of sarcopenia defined by the AWGS 2019 criteria and yielded comparable findings with previous studies in the context of proportions of the populations which fulfilled the predefined criteria for sarcopenia. 40 , 41 A cross-sectional investigation by Mo et al 40 showed a similar prevalence of sarcopenia, described by the AWGS 2019 criteria, in 21% of 1050 community-dwelling older people in Changsha City, China. Population characteristics and geographical location may potentially influence the prevalence of sarcopenia, even with the standardization of definitions using the AWGS criteria.…”

Section: Discussionmentioning

confidence: 69%

The Association Between Depressive Symptoms and Sarcopenia Among Community-Dwelling Older Adults: A Cross-Sectional Study

Zhang¹,

Chong²,

Tan³

et al. 2022

JMDH

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Purpose To evaluate the relationship between depressive symptoms and sarcopenia among older adults. Materials and Methods This is a cross-sectional study. A total of 700 community-dwelling older persons enrolled in this study. Sarcopenia is defined according to the Asian Working Group for Sarcopenia 2019 (AWGS 2019). The bioelectrical impedance analysis assessed muscle mass while a digital dynamometer quantified muscle strength. Furthermore, a 6-meter gait speed test measured physical performance. The Geriatric Depression Scale (GDS-30) screened for depressive symptoms. Data collected include those of socio-demographic, lifestyle, and comorbidity. Results The sample comprised 700 participants (455 women) with a mean age of 70.4±6.8 years. 21.5% had sarcopenia, among them, 5.6% at severe stage, while depressive symptoms were present in 8.1% (57/700). After adjusting for the potential confounders of age, sex, marital status, living status, hypertension, body mass index, and physical activity, the depressive symptoms that were found were not associated with sarcopenia but, instead, low gait speed. However, severe sarcopenia significantly impacted the risk of depressive symptoms, particularly in females. Conclusion Depressive symptoms are not associated with sarcopenia, but severe sarcopenia increases the risk of depressive symptoms in females, according to updated AWGS 2019 criteria. Gait speed is independently associated with depressive symptoms. The finding highlights that older people with sarcopenia should be screened for depressive symptoms, especially females. Future studies should evaluate the value of gait speed interventions for depressive symptoms among older adults.

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Section: Discussionmentioning

confidence: 69%

The Association Between Depressive Symptoms and Sarcopenia Among Community-Dwelling Older Adults: A Cross-Sectional Study

Zhang¹,

Chong²,

Tan³

et al. 2022

JMDH

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“…Common risk factors for sarcopenia include third age [ 8 , 9 ], low levels of physical activity, malnutrition [ 5 ], body mass index [ 9 ], and several co-morbidities, such as cardiovascular diseases, diabetes, respiratory diseases [ 10 ], human immunodeficiency virus (HIV) [ 11 ], and cancer [ 12 ]. Moreover, multiple pathogenesis mechanisms such as endocrine dysfunction, growth factors, neuromuscular junction, muscle protein changes, and inflammatory conditions increase the complexity of sarcopenia [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Nutritional and Nutrition-Related Biomarkers as Prognostic Factors of Sarcopenia, and Their Role in Disease Progression

et al. 2022

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Due to the multifactorial pathogenesis of sarcopenia, it is crucial to identify biomarkers that are risk factors for sarcopenia, and which therefore have a prognostic function. Aim: This narrative review aims to define a set of biomarkers associated with nutrition and sarcopenia. These biomarkers could contribute to individualized monitoring and enable preventive and therapeutic methods. Methods: Two electronic databases, PubMed and Google Scholar, were used. The search strategy was based on a controlled vocabulary (MeSH) and includes studies published up to February 2022. Discussion: Higher levels of serum uric acid are associated with higher handgrip strength and better muscle function in elderly people and, thus, may slow the progression of sarcopenia. Leptin, an adipokine secreted by adipose tissue, promotes the production of pro-inflammatory cytokines, which in turn lead to sarcopenia. This makes leptin a significant indirect biomarker for physical disability and sarcopenic obesity. Additionally, creatinine is a reliable biomarker for muscle mass status because of its easy accessibility and cost-effectiveness. Vitamin D status acts as a useful biomarker for predicting total mortality, hip fractures, early death, and the development of sarcopenia. Therefore, there is an increasing interest in dietary antioxidants and their effects on age-related losses of muscle mass and function. On the other hand, 3-Methylhistidine is a valuable biomarker for detecting increased muscle catabolism, as it is excreted through urine during muscle degradation. In addition, IGF-1, whose concentration in plasma is stimulated by food intake, is associated with the loss of skeletal muscle mass, which probably plays a crucial role in the progression of sarcopenia. Conclusions: Many nutritional biomarkers were found to be associated with sarcopenia, and can therefore be used as prognostic indexes and risk factors. Nutrition plays an important role in the prevention and management of sarcopenia, affecting muscle mass, strength, and function in elderly people.

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“…Sarcopenia is an involuntary resorption of skeletal muscle with decreased muscle strength and function (Sun et al, 2021 ), which has recently been considered as a new complication in diabetic patients (Cruz‐Jentoft et al, 2019 ; Sluijs et al, 2015 ; Yasemin et al, 2019 ). The pathogenesis of sarcopenia is complicated and associated with aging, sedentary lifestyle, nutritional factors, increased production of reactive oxygen species, increased levels of proinflammatory cytokines, hormonal changes, and decreased neuromuscular function (Chen et al, 2020 ; Tan et al, 2021 ; Trierweiler et al, 2018 ). Age‐related causes of sarcopenia are related with chronic inflammation due to oxidative stress and proinflammatory cytokines (Lima et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

The relationship of dietary total antioxidant capacity with sarcopenia and cardiometabolic biomarkers in type 2 diabetes patients

Baharirad

Pasdar

Nachvak

et al. 2022

Physiological Reports

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Background The aim of this study was to investigate the relationship of dietary total antioxidant capacity (DTAC) with sarcopenia and metabolic biomarkers in people with type 2 diabetes in the Kurdish race. Methods In this cross‐sectional study, data of 189 type 2 diabetic patients (35–65 years old) from RaNCD cohort study were evaluated. DTAC, fasting blood sugar, lipid profile, body composition, muscle strength, and sarcopenia were assessed. t and χ 2 tests to compare the variables between sarcopenic and non‐sarcopenic patients and one‐way analysis of variance to compare the variables in DTAC tertiles were used. The relationship between DTAC and different variables was evaluated using multiple logistic regression model. Results The mean age and body mass index were 49.7 ± 8.7 years and 27.1 ± 3.9 kg/m 2 . Body mass index, waist circumference, and hip circumference were significantly different between diabetic patients with and without sarcopenia ( p < 0.05). In crude ( p = 0.010) and adjusted ( p = 0.035) models, there was a significant relationship between DTAC and fasting blood sugar. Also, the relationship between DTAC with waist ( p = 0.019) and hip (β = −4.25, p = 0.026) circumference was significant. Sarcopenia was significantly lower in the third tertile in comparison with the first tertile of DTAC ( p = 0.016). Conclusion Diet with higher DTAC can be associated with lower fasting blood sugar, abdominal obesity and sarcopenia in type 2 diabetic patients. However, further studies are required to confirm these relationships.

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Analysis of the Prevalence of Sarcopenia and Its Risk Factors in the Elderly in the Chengdu Community

Cited by 24 publications

References 17 publications

The Association Between Depressive Symptoms and Sarcopenia Among Community-Dwelling Older Adults: A Cross-Sectional Study

The Association Between Depressive Symptoms and Sarcopenia Among Community-Dwelling Older Adults: A Cross-Sectional Study

Nutritional and Nutrition-Related Biomarkers as Prognostic Factors of Sarcopenia, and Their Role in Disease Progression

The relationship of dietary total antioxidant capacity with sarcopenia and cardiometabolic biomarkers in type 2 diabetes patients

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