2018
DOI: 10.1590/0074-02760170542 View full text |Buy / Rent full text
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Abstract: BACKGROUNDInfection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis.OBJECTIVESTo define the immunologic biomarkers that correlate with acute ZIKV infection.METHODSWe characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparis… Show more

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“…Together, these data confirm that ZIKV replication in the acute phase triggered rapid innate immune responses in peripheral blood. Several other chemoattractant chemokines (BLC/CXCL13, IP-10, MCP-1, RANTES, I-TAC, SDF-1α, and GRO-α) were also elevated during the ZIKV infection in chronically SIV/SHIV infected RMs described in this study, which is in accordance with previously described findings for ZIKV-infected individuals [ 19 ].…”
Section: Discussionsupporting
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“…Together, these data confirm that ZIKV replication in the acute phase triggered rapid innate immune responses in peripheral blood. Several other chemoattractant chemokines (BLC/CXCL13, IP-10, MCP-1, RANTES, I-TAC, SDF-1α, and GRO-α) were also elevated during the ZIKV infection in chronically SIV/SHIV infected RMs described in this study, which is in accordance with previously described findings for ZIKV-infected individuals [ 19 ].…”
Section: Discussionsupporting
“…Furthermore, besides the exceptions of MIF, IL-8, and SDF-1α, the cytokine/chemokine patterns of our RM were elevated during acute phase of ZIKV infection. Interestingly, this pattern is in accordance with previously described clinical findings for ZIKV-infected individuals [ 18 , 19 ]. Major elevation was observed for IL-1β and IFN-α in acute phase ZIKV infection was observed in SIV-ZIKV co-infected RMs.…”
Section: Discussionsupporting
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“…In contrast, other studies have found elevated levels of circulating cytokines and chemokines (again IP-10) in adults. However, plasma levels are highly dynamic and variable during the acute phase of ZIKV infection (Naveca et al, 2018). Thus, the profile and function of circulating cytokines during ZIKV infection and their role in the pathophysiology of the disease remain unclear.…”
Section: Discussionmentioning