Protective Effects of Caffeine on Chikungunya and Zika Virus Infections: An in Vitro and in Silico Study
Yeferson de Jesús López Medina,
Yordi Sebastián Tamayo‐Molina,
Juan Felipe Valdés‐López
et al.
Abstract:Infection by viruses Chikungunya (CHIKV) and Zika (ZIKV) continue to be serious problems in tropical and subtropical areas of the world. Here, we evaluated the antiviral and virucidal activity of caffeine against CHIKV and ZIKV in Vero, A549, and Huh‐7 cell lines. Results showed that caffeine displays antiviral properties against both viruses. By pre‐and post‐infection treatment, caffeine significantly inhibited CHIKV and ZIKV replication in a dose‐dependent manner. Furthermore, caffeine showed a virucidal eff… Show more
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