Analysis of the Expression and Prognostic Value of MSH2 in Pan-Cancer Based on Bioinformatics

Abstract

Background. MutS homolog 2 (MSH2), with the function of identifying mismatches and participating in DNA repair, is the “housekeeping gene” in the mismatch repair (MMR) system. MSH2 deficiency has been reported to enhance cancer susceptibility for the association of hereditary nonpolyposis colorectal cancer. However, the expression and prognostic significance of MSH2 have not been studied from the perspective of pan-cancer. Methods. The GTEx database was used to analyze the expression of MSH2 in normal tissues. The TCGA database was used to analyze the differential expression of MSH2 in pan-cancers. The prognostic value of MSH2 in pan-cancer was assessed using Cox regression and Kaplan-Meier analysis. Spearman correlations were used to measure the relationship between the expression level of MSH2 in pan-cancer and the level of immune infiltration, tumor mutational burden (TMB), and microsatellite instability (MSI). Results. MSH2 is highly expressed in most type of cancers and significantly correlated with prognosis. In COAD, KIRC, LIHC, and SKCM, the expression of MSH2 was significantly positively correlated with the abundance of B cells, CD4+ T cells, CD8+ T cells, dendritic cells, macrophages, and neutrophils. In THCA, MSH2 expression correlated with CD8+T Cell showed a significant negative correlation. MSH2 had significantly negative correlations with stromal score and immune score in a variety of cancers and significantly correlated with TMB and MSI of a variety of tumors. Conclusions. MSH2 may play an important role in the occurrence, development, and immune infiltration of cancer. MSH2 can emerge as a potential biomarker for cancer diagnosis and prognosis.

Mucinous adenocarcinoma aggravated by long-standing solitary rectal ulcer syndrome: a rare case report

“…(Iino et al, 1999) MSH2, functions in identifying mismatches and participating in DNA repair and MSH2 de ciency has been reported to enhance cancer susceptibility for the association of hereditary nonpolyposis colorectal cancer. (Qiu et al, 2021) The MSH6 protein provides instructions for producing proteins which play an essential role in repairing DNA. It can join with MSH2 protein to form a two-protein complex called a dimer, which identi es locations on the DNA where errors have been made during DNA replication.…”

A human pan-cancer system analysis of regulator of chromatin condensation 2

“…RCC2 was positively related to AUNIP, CCNF, MSH2, TIMELESS, and WDHD1 in most cancers. These five genes are linked to tumor formation, invasion, and DNA replication, with RCC2 and MSH2 previously regarded as molecular signatures for lung cancer malignancy [ [32] , [33] , [34] , [35] , [36] , [37] ]. In this work, RRP1B and SERBP1 oncogenes were obtained via intersection analysis of RCC2-interacted and RCC2-correlated genes.…”

CircWDR26 regulates endometrial carcinoma progression via miR-212-3p-mediated typing genes MSH2

“…Inhibition of miR-212-3p led to concomitant MSH2 upregulation and EC progression. Germline MSH2 mutation was associated with higher risks of ovarian and endometrial cancer [ 25 , 27 ], and the expression of MSH2 is associated with poor prognosis of uterine corpus endometrial carcinoma with a hazard ratio of 1.56 [ 38 ]. These data demonstrated that miR-212-3p regulated EC progression by MSH2.…”