Analysis of the cytokine profiles of the synovial fluid in a normal temporomandibular joint: Preliminary study

Kim, Young-Kyun; Kim, Su-Gwan; Kim, Bum Soo; Lee, Jeong-Yun; Yun, Pil‐Young; Bae, Jihyun; Oh, Ji‐Su; Ahn, Jong-Mo; Kim, Jae-Sung; Lee, Sook-Young

doi:10.1016/j.jcms.2012.02.002

Cited by 54 publications

(64 citation statements)

References 21 publications

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“…For the past few years, many papers have been published showing the participation of various markers and distinct pathways in the progression of TMJ ID using TMJ discs and synovial fluid (Kubota et al, 1998, De Alcantara Camejo et al, 2014, Loreto et al, 2013, Wake et al, 2013, Kim et al, 2012, Leonardi et al, 2010a, Vernal et al, 2008, Sato et al, 2003. Sato et al, in 2003, performed a study using also an immuno-histochemical technique for the examination of synovial tissue from 46 temporomandibular joints with internal derangement in 44 patients.…”

Section: Discussionmentioning

confidence: 99%

“…Cytokines have emerged as the master controllers of hard tissue degradation in human joint tissue in both osteoarthritis and inflammatory arthritis models (Nishimura et al, 2002, Fu et al, 1995. Kim et al (2012), using TMJ synovial fluid, demonstrated a higher expression of IL-1β, IL-6 and granulocyte macrophage colony stimulating factor (GM-CSF) in patients with temporomandibular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…Since the inflammatory process influences the progression of ID, this study was designed to test the hypothesis that IL-6 may be more highly expressed in the TMJ disc in cases of ADDwR and ADDwoR, and not only in the synovial fluid, as already extensively described in the literature (De Alcantara Camejo et al, 2014, Loreto et al, 2013, Kim et al, 2012, Sato et al, 2003.…”

Section: Discussionmentioning

confidence: 99%

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Interleukin-6 expression in disc derangement of human temporomandibular joint and association with osteoarthrosis

Camejo

Azevedo

Ambros

et al. 2017

Journal of Cranio-Maxillofacial Surgery

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The inflammatory process is a coordinated response that protects host after infection or trauma, involving several molecular reactions. Once the inflammation is closely linked to the process of destruction of the temporomandibular joint, this study aims to examine, by immunohistochemistry, the expression of interleukin-6 (IL-6), an important inflammatory marker, in temporomandibular articular discs of patients with anterior disc displacement with (ADDwR) and without reduction (ADDwoR) and its association with osteoarthrosis (OA). Thirty-eight (n = 38) articular discs were divided into two cutoffs: 1) analysis 1: 4 control (acute pathology), 17 ADDwR, 17 ADDwoR; and 2) analysis 2: without OA (n = 21) and with OA (n = 17). The area of immunostaining was compared statistically between groups (p < 0.05). In the disc samples, no significant differences were observed between the groups ADDwR and ADDwoR, and with and without OA, in respect to the expression of IL-6 by immunohistochemical examination. Future studies should be conducted with a larger sample size, which could clarify the association of the inflammatory mediator IL-6 with temporomandibular joint dysfunction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Interleukin-6 expression in disc derangement of human temporomandibular joint and association with osteoarthrosis

Camejo

Azevedo

Ambros

et al. 2017

Journal of Cranio-Maxillofacial Surgery

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“…This study, for the first time, focused on creating a tissueengineered SM of the TMJ with an original method, because we hold that an SM with abnormal function will cause continuous damage to the cartilage and disc rather than nourish them. For example, internal derangement of the TMJ is often accompanied by synovitis, during which cytokines such as vascular endothelial growth factor [Sato et al, 2005;Kumagai et al, 2010], interleukins [Suzuki et al, 1999;Sato et al, 2003;Vernal et al, 2008], tumor necrosis factor-α [Kaneyama et al, 2002;Vernal et al, 2008;Kim et al, 2012] and matrix metalloproteinases [Kubota et al, 1997;Tanaka et al, 2001] are highly expressed in synovial fluid or the SM. These cytokines are responsible for promoting vascular formation, causing pain and degrading the cartilage [Bonnet and Walsh, 2005], resulting in a poor clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

Triple-Layered Cell Sheet for Tissue-Engineering the Synovial Membrane of the Temporomandibular Joint

Li¹,

Cai²,

Fang³

et al. 2014

Cells Tissues Organs

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Objective: Temporomandibular disorder causes the dysfunction of fibroblast-like synoviocytes (FLSs) which are predominant in the lining layer (LL) of synovial membrane (SM) and responsible for the secretion function of the SM of the temporomandibular joint (TMJ). This study aimed to construct a triple-layered cell sheet (CS) for tissue-engineering the SM. Methods: FLSs were harvested and identified immunocytochemically. A triple-layered CS was fabricated by an original method of combining type I collagen and FLSs. Staining and a transmission electron microscope were used to compare the morphological similarities between the CS and the natural LL. Hyaluronic acid (HA) production and HA synthase 2 (HAS2) gene expression were assessed by ELISA and PCR, respectively. Transplantation of triple-layered CSs into nude mice was performed and examined by staining and immunohistochemical methods. Results: FLSs expressed vimentin, CD44 and heat shock protein 27. The triple-layered CS possessed a structure similar to natural LL. No tight conjunction was observed between adjacent FLSs. The triple-layered CS secreted HA at a quantity about 3 times that of the single-layered CS. The triple-layered structure induced higher expression of HAS2 in FLSs. No difference in HAS2 expression between the triple-layered CS and natural SM was observed. Multiple-layered FLSs and invasion of host fibroblasts and vessels were observed 2 weeks after transplantation. HAS2 and HA were expressed in surface cells and extracellular matrix, respectively. Conclusion: FLSs of the TMJ were type B synoviocytes. The triple-layered CS mimicked natural SM morphologically and functionally. The CS survived for 2 weeks in vivo. Therefore, triple-layered CS might be highly competent for tissue-engineered SM.

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“…TMJ osteoarthrosis (OA) which leads to TMJ pain and dysfunction is characterized by hard tissue destruction and degenerative changes. Internal derangement of the TMJ and OA are closely related entities (Emshoff et al, 2000;Kim et al, 2012aKim et al, , 2012b.…”

Section: Introductionmentioning

confidence: 99%

Tumor necrosis factor-alpha levels in the synovial fluid of patients with temporomandibular joint internal derangement

Güven

Tekin

Salmanoğlu

et al. 2015

Journal of Cranio-Maxillofacial Surgery

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Analysis of the cytokine profiles of the synovial fluid in a normal temporomandibular joint: Preliminary study

Cited by 54 publications

References 21 publications

Interleukin-6 expression in disc derangement of human temporomandibular joint and association with osteoarthrosis

Interleukin-6 expression in disc derangement of human temporomandibular joint and association with osteoarthrosis

Triple-Layered Cell Sheet for Tissue-Engineering the Synovial Membrane of the Temporomandibular Joint

Tumor necrosis factor-alpha levels in the synovial fluid of patients with temporomandibular joint internal derangement

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