Analysis of the Circular Transcriptome in the Synaptosomes of Aged Mice

Curry‐Hyde, Ashton; Ueberham, Uwe; Chen, Bei Jun; Zipfel, Ivonne; Bochmann, Jana; Jendrek, Renate; Takenaka, Konii; Kirazov, L.; Kirazov, E.; Jünger, Jennifer; Brückner, Martina K.; Arendt, Thomas; Janitz, Michael

doi:10.1016/j.neuroscience.2020.09.009

Cited by 8 publications

(4 citation statements)

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“…Another example is circ‐Mbl which is principally expressed in the Drosophila 's head than its ovaries (Westholm et al, 2014). On the other hand, developmental stage‐ or age‐related abundance of circRNAs, as the other characteristic, is defined as the alteration of circRNAs' expression level with the process of aging (Curry‐Hyde et al, 2020; Gruner et al, 2016; Meng et al, 2017).…”

Section: An Outlook On Circrnasmentioning

confidence: 99%

“…During the biogenesis of exonic circRNA (ecircRNA), direct backsplicing is preferred to be occurred instead of the exon skipping (Jeck & Sharpless, 2014). According to their composition, circRNAs can be categorized into four subclasses: (i) ecircRNAs; (Curry‐Hyde et al, 2020) circular intronic RNAs (ciRNAs); (iii) exon–intron circRNAs (EIciRNAs); and (iv) tRNA intronic circular RNAs (tricRNAs) (Geng et al, 2020). EcircRNAs, which are mostly distributed in the cytoplasm, have been reported as the most identified circRNAs (~80% of all subtypes) (Jeck et al, 2013; Memczak et al, 2013).…”

Section: An Outlook On Circrnasmentioning

confidence: 99%

Section: Biogenesis Of Circrnasmentioning

confidence: 99%

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Novel insights into the role of circular RNAs in Parkinson disease: An emerging renaissance in the management of neurodegenerative diseases

Dorostgou

Yadegar

Dorostgou

et al. 2022

J of Neuroscience Research

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Parkinson's disease (PD), as a debilitating neurodegenerative disease, particularly affects the elderly population, and is clinically identified by resting tremor, rigidity, and bradykinesia. Pathophysiologically, PD is characterized by an early loss of dopaminergic neurons in the Substantia nigra pars compacta, accompanied by the extensive aggregation of alpha-synuclein (α-Syn) in the form of Lewy bodies. The onset of PD has been reported to be influenced by multiple biological molecules. In this context, circular RNAs (circRNAs), as tissue-specific noncoding RNAs with closed structures, have been recently demonstrated to involve in a set of PD's pathogenic processes.These RNA molecules can either up-or downregulate the expression of α-Syn, as well as moderating its accumulation through different regulatory mechanisms, in which targeting microRNAs (miRNAs) is considered the most common pathway. Since circR-NAs have prominent structural and biological characteristics, they could also be considered as promising candidates for PD diagnosis and treatment. Unfortunately, PD has become a global health concern, and a large number of its pathogenic processes are still unclear; thus, it is crucial to elucidate the ambiguous aspects of PD pathophysiology to improve the efficiency of diagnostic and therapeutic strategies. In line with this fact, the current review aims to highlight the interplay between circRNAs and PD pathogenesis, and then discusses the diagnostic and therapeutic potential of circRNAs in PD progression. This study will thus be the first of its kind reviewing the relationship between circRNAs and PD.

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Section: An Outlook On Circrnasmentioning

confidence: 99%

Section: An Outlook On Circrnasmentioning

confidence: 99%

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Novel insights into the role of circular RNAs in Parkinson disease: An emerging renaissance in the management of neurodegenerative diseases

Dorostgou

Yadegar

Dorostgou

et al. 2022

J of Neuroscience Research

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“…The hippocampus has been shown to express specific regions of circRNAs in the mouse brain (Rybak-Wolf et al, 2015). Some studies have shown that circRNAs are specifically located in dendrite (You et al, 2015), axons (Qian et al, 2022) and synapses (Curry-Hyde et al, 2020), regulating synaptic plasticity (Xu et al, 2020). CircRNAs also play a causative role in aging and longevity, whose levels are also altered in an age-dependent manner across specific human organs and tissues (Kim et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice

Wang

Gao

et al. 2022

Front. Mol. Neurosci.

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IntroductionAge is an established risk factor for neurodegenerative disorders. Aging-related cognitive decline is a common cause of memory impairment in aging individuals, in which hippocampal synaptic plasticity and hippocampus-dependent memory formation are damaged. Circular RNAs (circRNAs) have been reported in many cognitive disorders, but their role in aging-related memory impairment is unclear.Methods: In this study, we aimed to investigate the effects of circ-Vps41 on aging-related hippocampus-dependent memory impairment and explore the potential mechanisms. Here, D-galactose was used to produce a conventional aging model resulting in memory dysfunction.ResultsCirc-Vps41 was significantly downregulated in D-galactose-induced aging in vitro and in vivo. The overexpression of circ-Vps41 could upregulate synaptophysin (Syp), thereby promoting the synaptic plasticity and alleviating cognitive impairment in aging mice. Mechanistically, we found that circ-Vps41 upregulated Syp expression by physically binding to miR-24-3p. Moreover, the miR-24-3p mimics reversed the circ-Vps41 overexpression-induced increase in Syp expression.DiscussionOverexpression of circ-Vps41 alleviated the synaptic plasticity and memory dysfunction via the miR-24-3p/Syp axis. These findings revealed circ-Vps41 regulatory network and provided new insights into its potential mechanisms for improving aging-related learning and memory impairment.

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Expression and function of circular RNAs in the mammalian brain

Zhang

2021

Cell. Mol. Life Sci.

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Analysis of the Circular Transcriptome in the Synaptosomes of Aged Mice

Cited by 8 publications

References 58 publications

Novel insights into the role of circular RNAs in Parkinson disease: An emerging renaissance in the management of neurodegenerative diseases

Novel insights into the role of circular RNAs in Parkinson disease: An emerging renaissance in the management of neurodegenerative diseases

Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice

Expression and function of circular RNAs in the mammalian brain

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