2022
DOI: 10.3389/fnmol.2022.1037912
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Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice

Abstract: IntroductionAge is an established risk factor for neurodegenerative disorders. Aging-related cognitive decline is a common cause of memory impairment in aging individuals, in which hippocampal synaptic plasticity and hippocampus-dependent memory formation are damaged. Circular RNAs (circRNAs) have been reported in many cognitive disorders, but their role in aging-related memory impairment is unclear.Methods: In this study, we aimed to investigate the effects of circ-Vps41 on aging-related hippocampus-dependent… Show more

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Cited by 9 publications
(7 citation statements)
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“…PSD-95 and SYP have a strong association with synaptic plasticity. 39 , 40 Interestingly, we detected significant decreases in PSD-95 and SYP expression after the downregulation of DHX9. It is well-known that PSD-95 modulates the formation of the postsynaptic density and affects synaptic plasticity via direct or indirect interactions with glutamate receptors and/or intracellular proteins.…”
Section: Discussionmentioning
confidence: 69%
“…PSD-95 and SYP have a strong association with synaptic plasticity. 39 , 40 Interestingly, we detected significant decreases in PSD-95 and SYP expression after the downregulation of DHX9. It is well-known that PSD-95 modulates the formation of the postsynaptic density and affects synaptic plasticity via direct or indirect interactions with glutamate receptors and/or intracellular proteins.…”
Section: Discussionmentioning
confidence: 69%
“…Trained Aplysia exposed to elevated pCO 2 resulted in specific molecular changes related to the habituation process, for example of vps-41 coding gene expression. Expression of circular mRNA of vps-41 improves synaptic plasticity and learning functions by acting as a “sponge” delivering miRNAs to regulate the transcriptome (84,85). Its upregulation under OA and after habituation training could therefore facilitate synaptic changes in the reflex circuitry.…”
Section: Discussionmentioning
confidence: 99%
“…CBD's established neuroprotective effects in vitro, as well as its potential to repair cognitive deficits in AD mice, warrant further exploration, particularly its influence on synaptic enhancement and neuronal protection in vivo. We analyzed the mRNA expression of the following essential synaptic proteins: GluA1 and GluA2 (AMPA receptor subunits); CaM-dependent protein kinase IIα (CamKIIα); synaptophysin (SYP); and DLG4, which encodes post-synaptic density protein 95 (PSD95) [33][34][35][36]. Our data indicate that CBD counteracts the Aβ 1-42 -induced decline in these mRNA levels in the mouse cerebral cortex (Figure 3A-E).…”
Section: Synaptic and Neurotrophic Modulation By Cbd In Aβ 1-42 -Indu...mentioning
confidence: 96%