Analysis of risk factors, presentation, and in-hospital events of very young patients presenting with ST-elevation myocardial infarction

Callachan, Edward; Alsheikh‐Ali, Alawi A.; Wallis, Lee

doi:10.1016/j.jsha.2017.01.004

Cited by 18 publications

(24 citation statements)

References 16 publications

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“…In our study, we found no relation in regards to HL history and none of our subjects had a history of familial combined hyperlipidaemia. However, patients requiring revascularization had lower HDL and higher TG levels, but had no statistically significant difference between LDL levels which was compatible with the majority of the studies (9,10,(29)(30)(31). Considering some patients were already on statin therapy we found that statin naïve patients had higher LDL and TG levels, and lower HDL levels in patients requiring revascularization.…”

Section: Discussionsupporting

confidence: 88%

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Risk Factors and Angiographic Characteristics of Coronary Artery Disease Requiring Revascularisation In Young Adults: A Single Centre Experience

Özkalaycı¹,

Gülmez

Altun

2019

Balıkesir Medical Journal

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Kardiyovasküler hastalık (KVH) en sık ölüm ve morbidite nedenlerindendir. İleri yaş aterosklerozun ilerlemesinde en önemli risk faktörlerinden biridir. Koroner arter hastalığı (KAH) genellikle erkeklerde 45 yaşın ve kadın popülasyonda 55 yaş üstünde görülür. Bununla birlikte, genç popülasyonda miyokard enfarktüsünün (MI) prevalansında önemli bir artış vardır. Bu çalışmanın amacı, kalp şikayetleri ile başvuran ve koroner anjiyografi (KAG) yapılan genç popülasyonda KAH için en yaygın risk faktörlerini tanımlamak ve tedavi stratejileri ile birlikte birincil ve ikincil önleme stratejilerini belirlemektir. Metod: Son 10 yıl içinde kardiyak şikayetlerle gelerek KAG yapılmış genç hastalar geriye dönük olarak tarandı. Çalışmaya toplam 113 olgu alındı. Revaskülarizasyon ihtiyaçlarına göre iki ana gruba ayrıldı. KAG sonrası koroner revaskülarizasyon gerektirmeyen olgular kontrol, (Grup 1); Koroner revaskülarizasyon ihtiyacı olanlar ise hasta grubu (Grup 2) şeklinde sınıflandırıldı. İstatistiksel analiz için SPSS 15.0 for Windows programı kullanıldı. Kategorik değişkenler için tanımlayıcı istatistikler; sayı ve yüzde olarak ifade edildi. Sayısal değişkenler için tanımlayıcı istatistikler; ortalama, standart sapma, minimum, maksimum, medyan şeklinde ifade edildi. İki değişkenli bağımsız değişkenlerin sayısal dağılımları normal dağılım koşulu sağladığında, Student t testi, normal dağılım koşulu sağlanamadığında Mann-Whitney U testi yapıldı. Bağımsız gruplardaki oranlar Ki kare testi ile karşılaştırıldı. Alfa'nın istatistiksel anlamlılık düzeyi p<0,05 olarak kabul edildi. Sonuç: Erkek cinsiyet prevalansı, gruplar arasında kadın cinsiyetten anlamlı olarak daha yüksekti (p=0.002). BKİ'nin ortalama değerinde gruplar arasında istatistiksel olarak anlamlı bir fark yoktu (p=0.105). Sigara ve ortalama sigara sayısı Grup 2'de anlamlı derecede yüksekti (p<0.001; p=0.002). İlave komorbiditeler açısından gruplar arasında istatistiksel olarak anlamlı bir fark yoktu. Anahtar kelimeler: genç erişkinde koroner arter hastalığı, aterosklerotik risk faktörleri

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Section: Discussionsupporting

confidence: 88%

“…Dyslipidaemia is found to be another cause of cardiovascular events among young population (9,10,16,(29)(30)(31)(32). In one study it was demonstrated that familial combined hyperlipidemia was associated with a 24-fold increased in acute coronary syndromes (8).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors and Angiographic Characteristics of Coronary Artery Disease Requiring Revascularisation In Young Adults: A Single Centre Experience

Özkalaycı¹,

Gülmez

Altun

2019

Balıkesir Medical Journal

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“…(18) Among young adults who consume cigarettes, there is a need for improved screening for risk factors. Earlier detection and treatment of dyslipidemia and hypertension could prevent acute cardiac events among subjects aged <40 years with multiple risk factors (19). In the group of older respondents (Group B), 62.5% had a reduced left ventricular ejection fraction (EFLV), and 37.5% of patients had normal EFLV.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Patients with Acute Myocardial Infarction According to Age

Džubur¹,

Gacic²,

Mekic³

2019

Med Arch

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Introduction: By development of the medicine, control of the risk factors for acute myocardial infarction (AMI), became the foundation of cardiology. Aim: To investigate the association of the age with presence of risk factors in patients with acute myocardial infarction. Methods: The study had a prospective, comparative and descriptive character, and it was done on a sample of 80 patients (n=80; 55 male and 25 female) Clinic for Heart, Blood Vessel and Rheumatic Diseases, Clinical Center University of Sarajevo from January 2016 to August 2018. All patients were hospitalized under the diagnosis of myocardial infarction and were divided into two main groups, which were divided into two subgroups according to age. Group A, group of patients under 45 years of age at the moment of diagnosis of AMI (n = 40; men = 29; women = 11) was divided into group A1 (n = 20; patients aged 25-35 years) and group A2 (n = 20; patients aged between 35-45 years). Group B, patients older than 45 years at the time of diagnosis of AMI (n = 40; men = 26, women = 14) was divided into group B1 (n = 20; patients aged between 45-55 years) and group B2 (n = 20; patients aged 55-65 years of age). Results: According to gender distribution, there is a significantly higher incidence of hypertension in male patients aged 25-35 years and between 35-45 years (p = 0.01; p = 0.01). Increased cholesterol values were significantly more common in men aged 25-35 years (p = 0.0121). Increased triglyceride values were significantly more common in men aged 25-35 years, in comparison to female respondents of the same age (86.67% vs. 13.33%, p = 0.0001). There was a significant significance between the two groups in the occurrence of anteroseptal (p = 0.04) and in the diaphragmatic myocardial infarction (p = 0.01), while in other infarction localities no significant significance was observed. Conclusion: Male sex is a predisposing risk factor for the development of a cardiovascular incident in the younger age. The post infarction ejection fraction of the left ventricle was significantly reduced in younger patients. The potential for prevention should be of paramount importance. The localization of the incident itself, and the involvement of a certain blood, represents, regardless of all the research, still a fact that is hard to stratify and directly correlated with a certain risk factor.

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“…По статистическим данным, ИБС у женщин до наступления менопаузы встречается значительно реже, чем у мужчин того же возраста. Пик заболеваемости приходится на возраст 65-75 лет, но в последние годы отмечено увеличение заболеваемости ИБС у фертильных женщин и молодых мужчин [5,6]. По данным проспективных исследований, ИБС болеют около 8-10 % мужчин в возрасте от 20 до 44 лет и 18-25 % в возрасте от 45 до 69 лет [7,8].…”

Section: Discussionunclassified

Blood lipids and angina pectoris (by epidemiological cardiological Rose questionnaire) in the population of 25-45 years of Novosibirsk

et al. 2019

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The aim of the study was to investigate the prevalence of angina pectoris (AP) according to the standardized epidemiological questionnaire of Rose in the population of 25–45 years of Novosibirsk and to identify its association with some lipid and non-lipid risk factors for coronary heart disease (CHD). Material and methods. Cross-sectional survey of the population aged 25–45 in Novosibirsk was carried out. The study included 1439 people (656 men and 783 women). Within the framework of the complex survey program, the standardized epidemiological questionnaire of Rose (WHO, 1984) was used. Blood levels of total cholesterol (total C), triglycerides (TG), low and high density lipoprotein cholesterol (LDL–C, HDL–C) were determinate by biochemical methods. Results. For all lipid indicators, significant differences were found between men and women. The levels of total C, TG and LDL–C were significantly higher, and the level of HDL–C was lower in men, than in women. According to the Rose questionnaire, out of 1439 people included in the study, 12 patients (0.8%) had AP (75% women). In persons with AP, blood levels of TG were 1.8 times higher, and the levels of HDL–C in blood was 1.2 times lower compared to persons without AP. Univariate analysis of associations of AP with CHD risk factors showed that the chance of developing angina pectoris in the population of 25–45 years was significantly increased in individuals with high blood TG levels (OR 3,515, DI 1,106–11,168, p = 0.039) and low HDL–C (OR 1,203, DI 1,054–1,372, p = 0.006). A natural, although statistically not significant (OR 3,165, p=0,055, due to the small number of groups with AP) increasing in the chance of developing AP in hypertension was detected. Conclusion. In the young population of 25–45 years in Novosibirsk, elevated blood levels of TG, reduced levels of HDL–C, and hypertension were associated with AP, according to Rosecardiological questionnaire, which underlines the importance of conducting screening surveys of the young population to improve effective prevention and treatment of diseases.

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Analysis of risk factors, presentation, and in-hospital events of very young patients presenting with ST-elevation myocardial infarction

Abstract: Among young adults who use tobacco, there is a need for improved screening for risk factors. Earlier detection and treatment of dyslipidemia and hypertension could prevent acute cardiac events among individuals aged <40 years with multiple risk factors.

Cited by 18 publications

References 16 publications

Risk Factors and Angiographic Characteristics of Coronary Artery Disease Requiring Revascularisation In Young Adults: A Single Centre Experience

Risk Factors and Angiographic Characteristics of Coronary Artery Disease Requiring Revascularisation In Young Adults: A Single Centre Experience

Comparison of Patients with Acute Myocardial Infarction According to Age

Blood lipids and angina pectoris (by epidemiological cardiological Rose questionnaire) in the population of 25-45 years of Novosibirsk

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