Analysis of PAEs in semen of infertile men

Wang, Shengyuan; Wang, Yu; Xie, Fangqin; Li, Yanxing; Wan, Xin; Ma, Wanyun; Wang, Decai; Wu, Yang‐Chang

doi:10.1179/2049396714y.0000000088

Cited by 14 publications

(10 citation statements)

References 31 publications

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“…Urinary concentrations were higher than those in other matrices with relatively low correlations between urine and seminal plasma (Frederiksen et al 2010, 2011). Another descriptive study found higher mean concentrations of 5 phthalates in the semen of 79 infertile men in comparison to 94 matched fertile men (Wang et al 2015), and other authors have reported negative associations between seminal plasma concentrations of EDCs and semen quality (Chang et al 2017; Vitku et al 2016). These findings highlight the importance of assessing non-persistent EDCs in seminal plasma relative to human fecundity.…”

Section: Introductionmentioning

confidence: 87%

Endocrine disrupting chemicals in seminal plasma and couple fecundity

Louis

Smarr

Sun

et al. 2018

Environmental Research

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Growing evidence supports the importance of men's exposure to non-persistent endocrine disruptors (EDCs) and couple fecundability, as measured by time-to-pregnancy (TTP). This evolving literature contrasts with the largely equivocal findings reported for women's exposures and fecundity. While most evidence relies upon urinary concentrations, quantification of EDCs in seminal plasma may be more informative about potential toxicity arising within the testes. We analyzed 5 chemical classes of non-persistent EDCs in seminal plasma for 339 male partners of couples who were recruited prior to conception and who were followed daily until pregnant or after one year of trying. Benzophenones, bisphenols, parabens, and phthalate metabolites and phthalate diesters were measured using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) except for phthalate diesters, which were analyzed using gas chromatography-mass spectrometry. Cox regression with discrete-time was used to estimate fecundability odds ratios (FORs) and 95% confidence intervals (CIs) for each chemical to estimate the probability of pregnancy. While most EDCs were detected in seminal plasma, concentrations were lower than urinary concentrations previously analyzed for the cohort. None of the EDCs were significantly associated with fecundability even after covariate adjustment, though benzophenones consistently yielded FORs <1.0 (ranging from 0.72 to 0.91) in couple-adjusted models suggestive of diminished fecundity (longer TTP). The findings underscore that a range of EDCs can be quantified in seminal plasma, but the lower concentrations may require a large cohort for assessing couple fecundability, as well as the need to consider other fecundity outcomes such as semen quality.

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Section: Introductionmentioning

confidence: 87%

Endocrine disrupting chemicals in seminal plasma and couple fecundity

Louis

Smarr

Sun

et al. 2018

Environmental Research

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“…A handful of studies have investigated the potential associations between DBP exposure and indicators of general fertility in men. These studies indicated that seminal levels of DBP 33 and urinary levels of one of its metabolites, mono- n -butyl phthalate (MnBP), 45 were significantly higher in infertile men when compared with fertile men. Further, urinary levels of MnBP, DBP, or another metabolite, monobutyl phthalate (MBP), were associated with lowered sperm concentration, 37,43–45,58 reduced total sperm count, 43 reduced sperm motility, 37,41,44,45,58 reduced proportions of morphologically normal sperm, 36,42 and reduced acrosin activity.…”

Section: Phthalatesmentioning

confidence: 99%

“…Specifically, seminal DEHP levels and urinary levels of the DEHP metabolites mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), but not the DEHP metabolites mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-oxo-hexyl) phthalate (MEOHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), or mono-(2-carboxymethylhexyl) phthalate (MCMHP), have been associated with male infer-tility. 13,33,34 Further, serum concentrations of the sum of DEHP metabolites or the individual metabolites (MEOHP, MEHHP, and MECPP) have been significantly associated with decreased semen volume and sperm count, 11,35–38 sperm concentration, 37,39,40 sperm motility, 11,36,39–42 percent of morphologically normal sperm, 36,43 and acrosin activity. 42 In contrast, several studies reported no associations between DEHP exposure and risk of subfertility, 9 fecundity, 13 sperm count, concentration, motility, or morphology.…”

Section: Phthalatesmentioning

confidence: 99%

“…A few studies have examined the associations between DEP exposure and fertility in men. Specifically, seminal levels of DEP and urinary levels of its metabolite monoethyl phthalate (MEP) have been significantly associated with male infertility, 33,45 reduced sperm count and concentration, 37,45 reduced sperm motility, 37 and reduced numbers of morphologically normal sperm. 36,37,45 However, a few studies have found no associations between urinary levels of MEP and subfertility in men, 9,13 as well as sperm count and concentration, motility, viability, and abnormal morphology.…”

Section: Phthalatesmentioning

confidence: 99%

“…Few studies have examined the associations between expo-sure to BBP and fertility in men. These studies showed that seminal levels of BBP were significantly higher in a group of infertile men when compared with a group of fertile men 33 and that paternal urinary levels of metabolite monobenzyl phthalate (MBzP) were significantly associated with an increased time to pregnancy, 13 decreased sperm count and concentration, 36,42,44 and reduced numbers of morphologically normal sperm. 36,42 Interestingly, some studies reported that urinary MBzP levels were associated with higher semen volume 43,59 as well as increased sperm concentration.…”

Section: Phthalatesmentioning

confidence: 99%

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Environmental Contaminants Affecting Fertility and Somatic Health

2017

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This review article summarizes the epidemiological findings published between 2011 and 2016 concerning bisphenol A (BPA), phthalates, dioxins, pesticides, air pollution, fracking chemicals, triclosan, and parabens and fertility parameters in men (i.e., semen volume, sperm concentration, sperm motility, and sperm morphology) as well as fertility parameters in women (i.e., cyclicity, fertility treatment outcomes), pregnancy outcomes (i.e., preterm birth,miscarriage), and reproductive disorders (i.e., polycystic ovary syndrome, endometriosis, and uterine fibroids). Overall, this review indicates that several environmental toxicants are significantly associated with reduced fertility parameters in men and women as well as several reproductive disorders in women. Although many studies reported that the selected exposures are associated with adverse fertility outcomes, several studies reported null associations. Thus, future studies are still needed to better elucidate the associations and potential mechanisms between these environmental chemicals and fertility outcomes in men and women.

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