Endocrine disrupting chemicals in seminal plasma and couple fecundity

Abstract

Growing evidence supports the importance of men's exposure to non-persistent endocrine disruptors (EDCs) and couple fecundability, as measured by time-to-pregnancy (TTP). This evolving literature contrasts with the largely equivocal findings reported for women's exposures and fecundity. While most evidence relies upon urinary concentrations, quantification of EDCs in seminal plasma may be more informative about potential toxicity arising within the testes. We analyzed 5 chemical classes of non-persistent EDCs in seminal plasma for 339 male partners of couples who were recruited prior to conception and who were followed daily until pregnant or after one year of trying. Benzophenones, bisphenols, parabens, and phthalate metabolites and phthalate diesters were measured using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) except for phthalate diesters, which were analyzed using gas chromatography-mass spectrometry. Cox regression with discrete-time was used to estimate fecundability odds ratios (FORs) and 95% confidence intervals (CIs) for each chemical to estimate the probability of pregnancy. While most EDCs were detected in seminal plasma, concentrations were lower than urinary concentrations previously analyzed for the cohort. None of the EDCs were significantly associated with fecundability even after covariate adjustment, though benzophenones consistently yielded FORs <1.0 (ranging from 0.72 to 0.91) in couple-adjusted models suggestive of diminished fecundity (longer TTP). The findings underscore that a range of EDCs can be quantified in seminal plasma, but the lower concentrations may require a large cohort for assessing couple fecundability, as well as the need to consider other fecundity outcomes such as semen quality.

A Review of Biomonitoring of Phthalate Exposures

“…Further, DEHP (4.20 µg/L) and DBP (2.06 µg/L) were reported at high concentrations in male seminal plasma from men in the US. The metabolites of DEHP (∑0.98 µg/L) and MBP (2.97 µg/L) also were present in considerable concentrations in seminal plasma in the same study [162]. These results suggested that phthalate metabolites can partition in seminal plasma.…”

Dichlorodiphenyltrichloroethane and the Adrenal Gland: From Toxicity to Endocrine Disruption

“…These are manifested in the suppression of the growth of the testes and the development of secondary sexual characteristics in young male chickens. It has been shown that changes in the testes are visible not only in the seminiferous tubules but also in the interstitial tissue [ 53 , 54 ]. Studies carried out on two groups of male rats receiving DDT with food at doses of 50 and 100 mg/kg of body weight showed dose-dependent decreases in the testes and sperm motility [ 55 ].…”

The Different Facets of Triclocarban: A Review

“…Human exposure to TCC may also be due to daily supplies, drinking water and dust [ 26 ]. As a result, its detection is frequent in human tissue, such as fingernails and body fluids, including blood, urine and seminal plasma [ 40 , 41 , 42 , 43 ], thus causing a potential hazard to human health. It is noteworthy that TCC may represent a risk for children, as it has been recently found in urine of Brazilian children and its use also seems to be associated to DNA damage [ 44 ].…”