Analysis of metformin, glimepiride and pioglitazone in human serum and its application to pharmacokinetics

Siddiqui, Farhan Ahmed; Sher, Nawab; Zubair, Arif; Shamshad, Hina; Shafi, Nighat; Mirza, Agha Zeeshan

doi:10.1039/c3ay40884a

Cited by 24 publications

(9 citation statements)

References 41 publications

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“…Glimepiride (GLMP) is a white to yellowish crystalline powder and insoluble in water (Siddiqui et al, 2013). Chemically it is 1- [[4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-ethyl] phenyl] sulfonyl]-3-trans-(4-methylcyclohexyl) urea ( Fig.…”

Section: Introductionmentioning

confidence: 99%

A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique

et al. 2015

European Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique

et al. 2015

European Journal of Pharmaceutical Sciences

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“…The main reasons for excluding articles were that validation was performed in solution [41][42][43][44][45][46][47][48][49][50][51][52] and method development without validation [53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72]. Validation in solution with subsequent extrapolation to biological samples is not encouraged due to the matrix effect, a factor that should be considered when developing a bioanalytical method [3][4][5] and that will be further discussed in this review.…”

Section: Systematic Literature Searchmentioning

confidence: 99%

A systematic and critical review on bioanalytical method validation using the example of simultaneous quantitation of antidiabetic agents in blood

Fachi

Leonart

Cerqueira

et al. 2017

Journal of Chromatography B

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A systematic and critical review was conducted on bioanalytical methods validated to quantify combinations of antidiabetic agents in human blood. The aim of this article was to verify how the validation process of bioanalytical methods is performed and the quality of the published records. The validation assays were evaluated according to international guidelines. The main problems in the validation process are pointed out and discussed to help researchers to choose methods that are truly reliable and can be successfully applied for their intended use. The combination of oral antidiabetic agents was chosen as these are some of the most studied drugs and several methods are present in the literature. Moreover, this article may be applied to the validation process of all bioanalytical.

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“…Stability study is the mandatory requirements of regulatory bodies, prior to marketing of a pharmaceutical product. It gives evidence about the quality of product around different environmental conditions and helps in establishing proper packaging, storage conditions and shelf life of the product [9] .There for the endeavour to develop analytical method for HZ should not only take into consideration the pharmaceutical strength and formulations Downloaded by [Erciyes University] at 22:08 04 January 2015 3 but also the stability studies and clinical applications. It will help to understand not only the actual strength of HZ in different dosage forms but also intrinsic stability of the product and quantification in plasma.…”

Section: Introductionmentioning

confidence: 99%

New Method Development for Hydroxyzine Determination: Application in Stability Studies, Pharmaceutical Formulations, and Humane Serum

Sher

Siddiqui

Fatima

et al. 2015

Journal of Liquid Chromatography & Related Technologies

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This article pertains to development and validation of an economically fast, sensitive and accurate Rp-HPLC method for quantitative analysis of HZ. A Hibar® μBondapak® C 18 column as stationary phase and acetonitrile: methanol: buffer (500:200:300) as mobile phase were used to accomplish the separation, when drawn at a flow rate of 1.0 mL/min, with 235 nm as monitoring wavelength. Linearity was established by studying the drug over the concentration range of 10-10000 ngmL -1 , correlation coefficient of r = 0.9993, drug recovery (97 to 102%) and high reproducibility in serum samples (less than 2.5% R.S.D) displayed excellent linearity, accuracy and precision. Force degradation studies of the drug under various stress conditions (acid, base, oxidation, photo and thermal) proved the stability indicating power of the method. Substantial method validation study was carried out inline with ICH guidelines and was applied successfully to quantify the amount of HZ in bulk, pharmaceutical formulations and blood serum samples. Downloaded by [Erciyes University]

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Analysis of metformin, glimepiride and pioglitazone in human serum and its application to pharmacokinetics

Cited by 24 publications

References 41 publications

A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique

A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique

A systematic and critical review on bioanalytical method validation using the example of simultaneous quantitation of antidiabetic agents in blood

New Method Development for Hydroxyzine Determination: Application in Stability Studies, Pharmaceutical Formulations, and Humane Serum

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