Analysis of IL1 gene polymorphisms and transcript levels in periodontal and chronic kidney disease

Braosi, Ana Paula Ribeiro; Souza, Cleber Machado de; Luczyszyn, Sônia Mara; Dirschnabel, Acir José; Claudino, Marcela; Olandoski, Márcia; Probst, Christian M.; Garlet, Gustavo; Pecoits‐Filho, Roberto; Trevilatto, Paula Cristina

doi:10.1016/j.cyto.2012.06.006

Cited by 32 publications

(31 citation statements)

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“…[43] The allele IL1RN *2 has been associated with reduced levels of gene transcripts in patients with periodontitis. [14] In the present work, the minor alleles IL1RN *2 (two repeats) and *3 (five repeats) were overrepresented in the AgP group, in comparison with controls [Table 3], which suggests their effects on the risk of AgP in our population. The minor alleles IL1RN *2, *3, *4, *5 also proved to be associated with AgP in Japanese,[7] Turkish,[44] and Iranian individuals,[45] but their presence was found not to be important for the development of AgP in Caucasians[123646] and Chinese populations.…”

Section: Discussionsupporting

confidence: 47%

“…[111431] Low prevalence of the IL1B +3954T allele has been reported in Chinese,[2832] Thai,[33] and Japanese populations. [7] In contrast, the prevalence of individuals carrying the variant allele is high in Caucasians (31-50%).…”

Section: Discussionmentioning

confidence: 99%

“…Few studies regarding the association of IL1 gene cluster haplotypes with periodontitis have been reported, but the comparison with our results was not possible since these studies included either different genes or different polymorphic loci. [1451]…”

Section: Discussionmentioning

confidence: 99%

“…Brazilian studies have been conducted, but in most of them, periodontitis was not classified into chronic and aggressive forms, or periodontitis was studied in relation to another pathological condition, such as chronic kidney disease[14] and human immunodeficiency virus infection. [15] In addition, several studies involved only the IL1B +3954C>T polymorphism or this polymorphism in combination with other polymorphic loci not considered in our work, and in some of them, the control group was not in Hardy–Weinberg equilibrium.…”

Section: Introductionmentioning

confidence: 99%

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Interaction of IL1B and IL1RN polymorphisms, smoking habit, gender, and ethnicity with aggressive and chronic periodontitis susceptibility

et al. 2016

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Background:Although the interleukin-1 (IL-1) plays a critical role in the pathogenesis of periodontitis, associations between IL1 gene cluster polymorphisms and the disease remains unclear.Aims:To investigate the importance of IL1B-511C>T (rs16944), IL1B +3954C>T (rs1143634), and IL1RN intron 2 variable number tandem repeat (VNTR) (rs2234663) polymorphisms, individually or in combination, as the risk factors of periodontitis in a Southeastern Brazilian population with a high degree of miscegenation.Subjects and Methods:A total of 145 individuals, with aggressive (aggressive periodontitis [AgP], n = 43) and chronic (chronic periodontitis [CP], n = 52) periodontitis, and controls (n = 50) were genotyped by polymerase chain reaction (PCR) (IL1RN intron 2 VNTR) or PCR-restriction fragment length polymorphism (PCR-RFLP) (IL1B-511 C>T and IL1B + 3954C>T) techniques.Statistical Analysis:The independent t-test, Chi-square, and Fisher's exact tests were used. The SNPStats program was used for haplotype estimation and multiplicative interaction analyses.Results:The IL1B +3954T allele represented risk for CP (odds ratio [OR] = 2.84), particularly in smokers (OR = 4.43) and females (OR = 6.00). The minor alleles IL1RN*2 and *3 increased the risk of AgP (OR = 2.18), especially the IL1RN*2*2 genotype among white Brazilians (OR = 7.80). Individuals with the combinations of the IL1B + 3954T and IL1RN*2 or *3-containing genotypes were at increased risk of developing CP (OR = 4.50). Considering the three polymorphisms (rs16944, rs1143634, and rs2234663), the haplotypes TC2 and CT1 represented risk for AgP (OR = 3.41) and CP (OR = 6.39), respectively.Conclusions:Our data suggest that the IL1B +3954C>T and IL1RN intron 2 VNTR polymorphisms are potential candidates for genetic biomarkers of periodontitis, particularly in specific groups of individuals.

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Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Interaction of IL1B and IL1RN polymorphisms, smoking habit, gender, and ethnicity with aggressive and chronic periodontitis susceptibility

et al. 2016

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“…Twenty-one case-control studies (9-29) were identified at finish of search in literature, included in this synthesis meta-analysis (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Relationship between -889 C/T polymorphism in interleukin-1A gene and risk of chronic periodontitis: Evidence from a meta-analysis with new published findings

Ac²,

Lf³

et al. 2016

Med Oral

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BackgroundPeriodontitis results from an inflammatory response caused by accumulative microorganisms in periodontal sites. Several factors are involved in pathogenesis of periodontitis, for example the -889 C/T polymorphism in interleukin-1A gene. This study aimed to evaluate the relationship between this polymorphism and risk of development of chronic periodontitis by a meta-analysis based in new published findings.Material and MethodsThereunto a review in literature was performed in the electronic biomedical and education databases (Cochrane Library, Google Scholar, MEDLINE and PubMed) to studies published before August 2, 2015, the abstracts were evaluated and the data extraction performed by two calibrated examiners. The calculations of the meta-analysis were obtained through statistical software Review Manager version 5.2 with calculation of Odds Ratio (OR), heterogeneity (I²) and Funnel plots with P <0.05.ResultsIn overall, twenty-one case/control studies were selected with 2,174 patients with chronic periodontitis and 1, 756 controls. The meta-analysis showed T allele was associated with chronic periodontitis (OR = 1.22, 95% CI: 1.09, 1.36, P = 0.0004) with decreased value to heterogeneity (I² = 15%, P = 0.28). TT genotype was associated to patients with chronic periodontitis (OR = 1.40, 95% CI: 1.07, 1.83, P = 0.01). No publication bias was found in this meta-analysis by asymmetry in Funnel plots.ConclusionsThis meta-analysis with 2,174 patients with chronic periodontitis and 1, 756 controls evidenced the -889 C/T polymorphism is associated to risk of development of chronic periodontitis with no significant value to heterogeneity to allelic evaluation. Key words:Alleles, odds ratio, periodontal disease, cytokines.

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Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects

Salum

Castro

Moreira

et al. 2019

American J Industrial Med

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Introduction: Silicosis is a fibrotic lung disease resulting from the inhalation of crystalline silica and can be classified as simple or complicated according to the International Labour Organization criteria. Furthermore, individuals exposed to crystalline silica also have a higher risk for the development of tuberculosis (Tb).The contribution of inflammatory cytokines to the risk of silicosis and Tb in different populations has previously been reported. Since genetic background might be related to susceptibility to silicosis and Tb, the study of polymorphisms within IL-1α, IL-1β, and tumor necrosis factor protein-coding genes may contribute to elucidating the genetic basis of these diseases.Methods: Single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction using restriction fragment length polymorphism or by Taqman methodology, in a sample of 102 silica-exposed patients from Brazil.Results: No significant associations were observed between the SNPs studied and the severity of silicosis. However, significant associations were found between Tb and the C allele (odds ratio [OR] = 1.93, 95% confidence interval [CI], 1.01-3.73) and the CC genotype (OR = 2.34, 95% CI, 1.04-5.31) of IL1A −899C>T. The IL1B +3954C>T polymorphism also showed an association with Tb (T allele dominant model OR = 2.38, 95% CI, 1.04-5.41). Conclusion:These preliminary results demonstrate that the IL1A and IL1B gene variations may contribute to some extent to susceptibility to Tb, but not silicosis.However, additional studies are still needed to confirm these results.

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Analysis of IL1 gene polymorphisms and transcript levels in periodontal and chronic kidney disease

Cited by 32 publications

References 43 publications

Interaction of IL1B and IL1RN polymorphisms, smoking habit, gender, and ethnicity with aggressive and chronic periodontitis susceptibility

Interaction of IL1B and IL1RN polymorphisms, smoking habit, gender, and ethnicity with aggressive and chronic periodontitis susceptibility

Relationship between -889 C/T polymorphism in interleukin-1A gene and risk of chronic periodontitis: Evidence from a meta-analysis with new published findings

Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects

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