Analysis of Forbidden Pharmaceutical Compouinds in Antirheumatic Jamu

Mustarichie, Resmi; Ramdhani, Danni; Indriyati, Wiwiek

doi:10.22159/ajpcr.2017.v10i4.16101

Cited by 12 publications

(14 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many of the case reports summarised in these tables lack details that would be important for a rigorous hazard and risk assessment. For instance, some fail to mention the exact level of the APIs detected in the samples showing their presence only by qualitative analysis using thin layer chromatography (TLC) (Gitawati 2013;Wisnuwardhani et al 2013;Fauziah et al 2015;Mustarichie et al 2017), a spot test (Hanum et al 2017), or a qualitative chemical test (Maesaroh 2020). Other issues hampering hazard and/or risk assessment are the simultaneous presence of more than one API (Lau et al 2003;Doshi et al 2009), or the lack of a description of the recommended daily use of these jamu samples to assess the potential exposure to APIs resulting from consuming the jamu.…”

Section: Emerging Hazards and Risk Characterisation Of Apis That Are Non-genotoxicmentioning

confidence: 99%

Risk characterisation of constituents present in jamu to promote its safe use

Suparmi

Wahidin²,

Rietjens

2021

Critical Reviews in Toxicology

View full text Add to dashboard Cite

Safety in use of jamu consumption, as part of traditional medicine from Indonesia, is dependent on the complete and adequate assessment of potential hazards and risks of the botanicals and botanical constituents included. This includes especially hazards and risks related to the presence in jamu of active pharmaceutical ingredients (APIs) as well as of constituents that are genotoxic and carcinogenic. The present review presents an overview of the current state-of-the art on these hazards and risks based on case reports on adulteration, and the actual detection of genotoxic and carcinogenic ingredients of concern in jamu. Based on the overview thus obtained, it appears that drug-adulteration presents important hazards responsible for potential adverse effects, due to overdosing. The potential hazards of exposure to APIs mainly relate to the presence of constituents that may cause liver damage, renal impairment, kidney failure, steroid dependence or genotoxicity and carcinogenicity. For these APIs, a risk characterisation was performed based on comparison of health-based guidance values (HBGVs) and exposure, while for the genotoxic carcinogens the margin of exposure (MOE) approach was used. Results of this risk characterisation should be used by risk managers to impose specification for constituents of health concern to protect consumers. It is concluded that to manage the risks identified and further improve the safety in use of jamu, a collaboration between farmers, manufacturer/producers, academia, government, health professionals, and consumers is indicated.

show abstract

Section: Emerging Hazards and Risk Characterisation Of Apis That Are Non-genotoxicmentioning

confidence: 99%

Risk characterisation of constituents present in jamu to promote its safe use

Suparmi

Wahidin²,

Rietjens

2021

Critical Reviews in Toxicology

View full text Add to dashboard Cite

show abstract

“…Paracetamol merupakan obat analgesik yang aman jika dikonsumsi sesuai aturan. Apabila seseorang mengonsumsi paracetamol dalam waktu yang lama, paracetamol akan terakumulasi dalam tubuh dan menyebabkan kerusakan hati dikarenakan radikal bebas berupa N-acetylpbenzoquinoneimine (NAPQI) tidak bisa dibersihkan oleh enzim glutation yang ada di dalam hati (Mustarichie, Ramdhani, & Indriyati, 2017).…”

Section: Hasil Dan Pembahasanunclassified

Edukasi Dokter kepada Pengonsumsi Jamu Kemasan sebagai Obat Penghilang Lelah

Arwinda¹

2019

Preprint

View full text Add to dashboard Cite

Jamu or Indonesian traditional medicine is very popular among society. The demand enhancement of jamu brought industrial world to develop jamu into modern and instant form. They can give a low-cost and society friendly. Researchers also do researches to find out if there are substances that are not allowed to be included. Researchers also have result of their research that majority of instant jamu in society have composition of chemical substances such as corticosteroid, paracetamol, and mefenamic acid. Those compounds are very dangerous to be consumed in long-term period due to the side effects which are able to deliver metabolism abnormalities. People among society, especially in village, have no awareness in consuming that instant jamu. So that, doctor has a major role to deliver education to those people in order to decrease risk factor of metabolism abnormalities in the future.

show abstract

“…This method is cheaper and does not need to use hazardous combine solvents as well as chloroform, acetone, methanol and amonia eluent that used in qualitative testing using the Thin Layer Chromatography method. 10 This study is developing a prototype of paper-based color test-strip to detect chemical paracetamol in 10 Jamu samples in the Samarinda region.…”

Section: Introductionmentioning

confidence: 99%

Development of Paper-Based Color Test-Strip for Paracetamol Detection in Jamu

Sentat

Nurhasnawati

Dwinand³

2020

J. Ilmu Kesehat.

View full text Add to dashboard Cite

Chemical medicine which are synthetic chemicals or isolation products must not be added to herbal medicine, that was standared by Indonesian Head of the Drug and Food Control Agency in statement regarding Criteria and Procedure for Registration of Traditional Medicines, Standardized Herbal Medicines, and Phytofarmaka. This study aims to develope prototype of paper-based color test-strip to identify paracetamol trace in several types of Indonesian herbal medicine, better known as Jamu. Research conducted with experimental research wich make paper test-strip prototype by immobilizing reagents into Whatman’s filter paper, then it used to identify paracetamol in extracted Jamu samples. The paracetamol qualitative test uses 10 Jamu samples that distributed in Samarinda area. were also carried out on. Comparison methode with qualitative color reaction tests using specific reagents in the laboratory were also carried out beside the paper-based color test-strip methode. In addition with positive control tests using 5000 ppm paracetamol solution to make sure both methode used are valid. The results of this study showed that two prototype paper-based color test-strips containing 10% iron (III) chloride reagent and folin ciocalteu were able to detect the presence of paracetamol chemicals in Jamu samples with color reaction.

show abstract

Analysis of Forbidden Pharmaceutical Compouinds in Antirheumatic Jamu

Cited by 12 publications

References 3 publications

Risk characterisation of constituents present in jamu to promote its safe use

Risk characterisation of constituents present in jamu to promote its safe use

Edukasi Dokter kepada Pengonsumsi Jamu Kemasan sebagai Obat Penghilang Lelah

Development of Paper-Based Color Test-Strip for Paracetamol Detection in Jamu

Contact Info

Product

Resources

About