Analysis of estrogens and estrogen mimics in edible matrices—A review

Adamusová, Hana; Bosáková, Zuzana; Coufal, Pavel; Pacáková, Věra

doi:10.1002/jssc.201301234

Cited by 22 publications

(10 citation statements)

References 154 publications

(148 reference statements)

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“…In fact samples are often constituted by complicated matrices, where initially the compound of interest must be extracted from, then isolated, identified and quantified. Several analytical methods are nowadays available to detect estrogenic EDCs, depending on the nature of the sample to analyze (milk, meat, miscellaneous matrices, fish, packaging materials, etc) in a cost-effective way, and increasing efforts in finding more sensible and accurate analytical methods are currently underway (Adamusova et al, 2014; Capriotti et al, 2013; Wang et al, 2008; Kudlaka et al, 2015; Rotroff et al 2014). …”

Section: Synthetic Xenoestrogens: Endocrine Disrupting Chemicals (mentioning

confidence: 99%

Risks and benefits related to alimentary exposure to xenoestrogens

Paterni

Granchi

Minutolo

2017

Critical Reviews in Food Science and Nutrition

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Xenoestrogens are widely diffused in the environment and in food, thus a large portions of human population is worldwide exposed to them. Among alimentary xenoestrogens, phytoestrogens (PhyEs) are increasingly being consumed because of their potential health benefits, although there are also important risks associated to their ingestion. Furthermore, other xenoestrogens that may be present in food are represented by other chemicals possessing estrogenic activities, that are commonly defined as endocrine disrupting chemicals (EDCs). EDCs pose a serious health concern since they may cause a wide range of health problems, starting from pre-birth till adult lifelong exposure. We herein provide an overview of the main classes of xenoestrogens, which are classified on the basis of their origin, their structures and their occurrence in the food chain. Furthermore, their either beneficial or toxic effects on human health are discussed in this review.

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Section: Synthetic Xenoestrogens: Endocrine Disrupting Chemicals (mentioning

confidence: 99%

Risks and benefits related to alimentary exposure to xenoestrogens

Paterni

Granchi

Minutolo

2017

Critical Reviews in Food Science and Nutrition

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“…With respect to exoestrogens, which can be either naturally (e.g., phytoestrogens and mycoestrogens ) or synthetically (e.g. bisphenol A, and alkylphenols ) produced, natural estrogens possess a much more powerful estrogenic activity; however, few studies have addressed the exposure of consumers to naturally occurring steroids in food of animal origin . Natural estrogens are involved in the estrous cycle of mammals and include estrone (E1), 17β‐estradiol (βE2), 17α‐estradiol (αE2), and 17β‐estriol (E3).…”

Section: Introductionmentioning

confidence: 99%

Natural estrogens in dairy products: Determination of free and conjugated forms by ultra high performance liquid chromatography with tandem mass spectrometry

Cavaliere

Capriotti

Foglia

et al. 2015

J of Separation Science

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Natural estrogens are synthesized by mammals in different amounts depending on the developmental stage and pregnancy/lactation period, and they may pass into milk, where they are mostly present as glucuronated and sulfated forms. In modern dairy practices, about 75% of milk is produced from pregnant cows; therefore, the amount of hormones that may pass into milk could be of concern. While estrogen determination in milk has been investigated in depth, the individual determination of estrogens and their conjugated forms in dairy products has not been fully addressed. The aim of this work was to develop and assess a sensitive method, using the peculiar retention properties of graphitized carbon black, to extract natural free estrogens and their major conjugated metabolites, without any enzymatic cleavage, from yogurt, cheese, and butter. The free and conjugated estrogens were eluted in two distinct fractions from the solid-phase extraction cartridge and analyzed separately by ultra high performance liquid chromatography coupled to tandem mass spectrometry. Recoveries were higher than 80% for all the three sample typologies. The highest matrix effects were observed for butter, which was richest in lipid content, but was below 30%. A survey on some commercial dairy products suggests that production processes decreased estrogen content.

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“…Exposure to very low concentrations of these compounds can be detrimental to health. Bisphenol A (BPA) and alkylphenols (APs) including 4‐octylphenol (OP) and 4‐nonylphenol (NP) are such endocrine disruptors that have been widely used in industrial manufacture . Humans are easily exposed to BPA, OP, and NP via foods and drinks.…”

Section: Introductionmentioning

confidence: 99%

Determination of bisphenol A, 4-octylphenol, and 4-nonylphenol in soft drinks and dairy products by ultrasound-assisted dispersive liquid-liquid microextraction combined with derivatization and high-performance liquid chromatography with fluorescence dete

Zhao

Zhu

et al. 2014

J. Sep. Science

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A novel hyphenated method based on ultrasound-assisted dispersive liquid-liquid microextraction coupled to precolumn derivatization has been established for the simultaneous determination of bisphenol A, 4-octylphenol, and 4-nonylphenol by high-performance liquid chromatography with fluorescence detection. Different parameters that influence microextraction and derivatization have been optimized. The quantitative linear range of analytes is 5.0-400.0 ng/L, and the correlation coefficients are more than 0.9998. Limits of detection for soft drinks and dairy products have been obtained in the range of 0.5-1.2 ng/kg and 0.01-0.04 μg/kg, respectively. Relative standard deviations of intra- and inter-day precision for retention time and peak area are in the range of 0.47-2.31 and 2.76-8.79%, respectively. Accuracy is satisfactory in the range of 81.5-118.7%. Relative standard deviations of repeatability are in the range of 0.35-1.43 and 2.36-4.75% for retention time and peak area, respectively. Enrichment factors for bisphenol A, 4-octylphenol, and 4-nonylphenol are 170.5, 240.3, and 283.2, respectively. The results of recovery and matrix effect are in the range of 82.7-114.9 and 92.0-109.0%, respectively. The proposed method has been applied to the determination of bisphenol A, 4-octylphenol, and 4-nonylphenol in soft drinks and dairy products with much higher sensitivity than many other methods.

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Analysis of estrogens and estrogen mimics in edible matrices—A review

Cited by 22 publications

References 154 publications

Risks and benefits related to alimentary exposure to xenoestrogens

Risks and benefits related to alimentary exposure to xenoestrogens

Natural estrogens in dairy products: Determination of free and conjugated forms by ultra high performance liquid chromatography with tandem mass spectrometry

Determination of bisphenol A, 4-octylphenol, and 4-nonylphenol in soft drinks and dairy products by ultrasound-assisted dispersive liquid-liquid microextraction combined with derivatization and high-performance liquid chromatography with fluorescence dete

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