Analysis of enantiomers in biological matrices by charged cyclodextrin-mediated capillary zone electrophoresis in column-coupling arrangement with capillary isotachophoresis

Mikuš, Peter; Kubacák, P; Valášková, Iva; Havránek, E

doi:10.1016/j.talanta.2006.02.013

Cited by 26 publications

(30 citation statements)

References 19 publications

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“…Table 2 shows that cITP was used as preconcentration technique to determine different antihistaminic drugs in a biological sample as urine [25] and to detect several drugs in standard solutions by CE-NMR [26]. Likewise, this table also shows the use of tITP for the preconcentration of R,S-timolol [27].…”

Section: In-capillary Preconcentration Techniques Based On Electrophomentioning

confidence: 99%

“…Likewise, this table also shows the use of tITP for the preconcentration of R,S-timolol [27]. Thus, Mikus et al [25] proposed a highly sensitive cITP-EKC method combining two coupled capillaries: in the first capillary, ITP was carried out to achieve a preseparation and a sample preconcentration, and in the second capillary, where the sample was transferred on-line, the EKC separation occurred. These experiments showed favorable conditions for the separation and determination of traces (ng/mL) of antihistaminic drugs (dioxopromethazine (DIO), dimethindene (DIM), and pheniramine (PHM)) enantiomers present in urine samples diluted with water.…”

Section: In-capillary Preconcentration Techniques Based On Electrophomentioning

confidence: 99%

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Sensitive chiral analysis by CE: An update

et al. 2007

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Sensitive chiral analysis by CE: An updateA general view of the different strategies used in the last years to enhance the detection sensitivity in chiral analysis by CE is provided in this article. With this purpose and in order to update the previous review by García-Ruiz et al., the articles appeared on this subject from January 2005 to March 2007 are considered. Three were the main strategies employed to increase the detection sensitivity in chiral analysis by CE: (i) the use of off-line sample treatment techniques, (ii) the employment of in-capillary preconcentration techniques based on electrophoretic principles, and (iii) the use of alternative detection systems to the widely employed on-column UV-Vis absorption detection. Combinations of two or three of the above-mentioned strategies gave rise to adequate concentration detection limits up to 10 210 M enabling enantiomer analysis in a variety of real samples including complex biological matrices.

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Section: In-capillary Preconcentration Techniques Based On Electrophomentioning

confidence: 99%

Section: In-capillary Preconcentration Techniques Based On Electrophomentioning

confidence: 99%

Sensitive chiral analysis by CE: An update

et al. 2007

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“…The BGE composition was fine-tuned to reduce dispersion effects and increase resolution. The combination of CITP with CZE, using CE-b-CD, was shown to reduce interferences and concentrate the sample for analysis of enantiomers in urine [79]. The pH was adjusted to optimize CD ionization and enantioresolution.…”

Section: Carboxyalkyl-derivatized Anionic Cdsmentioning

confidence: 99%

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

Kahle

Foley

2007

Electrophoresis

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Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKCThe separation of enantiomers using electrokinetic chromatography (EKC) with chiral microemulsions is comprehensively reviewed through December 1, 2006. Aqueous chiral EKC separations based on other pseudostationary phases such as micelles and vesicles or on other chiral selectors such as CDs, crown ethers, glycopeptides, ligand exchange moeities are also reviewed from both mechanistic and applications perspective for the period of

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“…The presence of this segment results from the fact that we do not want to lose a part of the analyzed zones and we must make a cut generously. The zone of this segment survives for a certain time during the CZE stage and this mean that ITP migration continues also in the second capillary for some time and it influences strongly the results of the analysis, especially the detection times of analytes used for identification of the analytes in CZE separations (Busnel et al, 2006;Gebauer et al, 2007;Mikuš et al, 2006a). From this is clear that it is important in an ITP-CZE combination to choose suitable electrolyte systems and find the optimum time to switch the current from the preseparation capillary to the separation capillary (Křivánková et al, 1995).…”

Section: Itp-czementioning

confidence: 99%