Analysis of brain regional distribution of aluminium in rats via oral and intraperitoneal administration

Sánchez-Iglesias, Sofía; Soto‐Otero, Ramón; Iglesias-Gonzalez, Javier; Barciela‐Alonso, María Carmen; Bermejo-Barrera, Pilar; Méndez-Álvarez, Estefanı́a

doi:10.1016/j.jtemb.2007.09.010

Cited by 55 publications

(36 citation statements)

References 20 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can cross the blood-brain barrier and may be deposited in brain tissue [9–11]. It deposits in most areas of the brain (the cerebellum, ventral midbrain, cortex, hippocampus, and striatum), depending on the form of exposure: a greater and more significant increase was noted in the group of rats receiving aluminum via an intraperitoneal administration, then in rats receiving aluminum via an oral administration [9, 72, 73]. The neurodegenerative effects of the intracisternal injection of Al included the formation of intraneuronal neurofilamentous aggregates, oxidative stress, and apoptosis [74].…”

Section: Discussionmentioning

confidence: 99%

“…This element has long been implicated in the pathogenesis of Alzheimer’s disease, but the precise mechanism of aluminum toxicity in this disease remains unknown [8]. Deposition can occur throughout the brain, as Al can cross the blood-brain barrier [9–11]. Disorders of steroidogenesis may arise through the deposition of Al in the hypothalamus and pituitary gland.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Aluminum Exposure on Reproductive Ability in the Bank Vole (Myodes glareolus)

Miska-Schramm

Kapusta

Kruczek

2016

Biol Trace Elem Res

View full text Add to dashboard Cite

Human impact on the environment is steadily increasing the amounts of aluminum in the ecosystems. This element accumulates in plants and water, potentially exposing herbivores to its harmful effect. In heavily polluted sites, a decrease in the density of small rodent populations has been observed. This decline may be caused by many factors, including decreased fertility. The aim of the presented research was to determine how aluminum, administered at concentrations similar to those recorded in industrial districts (Al I = 3 mg/l, Al II = 200 mg/l), affects the reproductive abilities of small rodents. As the indicators of reproductive abilities, body weight, weight of the testes and accessory sex glands of males, and uterus weight of females were estimated. In females, the number of matured follicles (types 6, 7, and 8) was analyzed, while in males, the quantity and quality (matured, viable, swollen, motile, head abnormalities) of epididymal sperm cells were assessed. Moreover, the development of testes, measured by spermatogenic index, was determined. The model species was the bank vole. Our results have proven that aluminum impairs adult individuals’ reproductive abilities by decreasing the quality and quantity of sperm cells and by causing morphologically abnormal development of the gonads. However, no difference in male organometric parameters was found, and only in females treated with 3 mg/l Al, the uterus weight was higher than control. No differences were found in the total number of matured follicles. These results suggest that the decline in rodent numbers in industrial districts is due, at least in part, to poorer males’ reproductive abilities, resulting from exposure to aluminum contamination.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Aluminum Exposure on Reproductive Ability in the Bank Vole (Myodes glareolus)

Miska-Schramm

Kapusta

Kruczek

2016

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…Unfortunately, the form by which aluminium crosses membranes and the intracellular consequences of the form remains largely speculative [18], but it is known that aluminium chemical speciation is a conditioner for its absorption and tissue distribution and accumulation [49]. Several chemical forms of aluminium such as aluminium maltol [21,23,50], aluminium chloride [13,51], aluminium hydroxide [52] and aluminium citrate [53][54][55] have been applied. In the present experiments, aluminium citrate was adopted because it is found to be next in order of abundance to the transferrin aluminium complex in the body [56,57].…”

Section: Discussionmentioning

confidence: 99%

“…Aluminium is toxic to all organisms [10]. Aluminium accumulates in all tissues of mammals such as the kidneys, liver, heart, blood, bones and brain [11][12][13]. Accumulation of aluminium in biological systems has been linked to disease conditions such as dialysis encephalopathy, renal osteodystrophy, hypochromic microcytic anemia [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Up-regulation in the expression of renin gene by the influence of aluminium

Ezomo

Matsushima

Meshitsuka

2009

Journal of Inorganic Biochemistry

View full text Add to dashboard Cite

The excretion of aluminium in urine was significantly increased after intake of analgesics containing aluminium, confirming increased absorption and hence exposure to aluminium with such medication. The effect of aluminium on the kidney was further investigated by study of gene expression in mice. After a single dose of aluminium, an up-regulation of renin gene was found by DNA sequencing of the products of differential display analysis. The up-regulation of renin was confirmed by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting experiments in the dose dependent treatments and the time course observation after aluminium citrate injection. The up-regulation of the renin expression by aluminium is a strong indication of the influence of aluminium on the renin-angiotensin-aldosterone-system, resulting in possible induction of essential hypertension.

show abstract

“…Aluminium can cross and alter the blood-brain barrier (Yokel 2002), and differentiated distribution of aluminium in the distinct brain areas depends on the route of exposure (Sánchez-Iglesias et al 2007;Zatta et al 1993). It is known that aluminium exhibits very slow clearance from brain, but other organs also accumulate significant amounts of aluminium over time (Walker et al 1994;Yokel et al 2001).…”

mentioning

confidence: 99%

Life and death in aluminium-exposed cultures of rat lactotrophs studied by flow cytometry

et al. 2010

View full text Add to dashboard Cite

Prolonged exposure to aluminium may impact health. Aluminium's deleterious effects are mostly attributed to its selective accumulation in particular organs and cell types. Occupational exposure to aluminium is allied with a reduced level of serum prolactin, a stress peptide hormone mainly synthesised and secreted by the anterior pituitary lactotrophs. Our aim was to study the effect of aluminium on the viability of rat lactotrophs in primary suspension cultures where multicellular aggregates tend to form, comprising approximately two thirds of the total cell population as confirmed by confocal microscopy. Flow cytometric light scattering of calcein acetoxymethyl ester and ethidium homodimer-1 labelled cells was used to define subpopulations of live and dead cells in heterogeneous suspensions comprised of single cells and multicellular aggregates of distinct size. Concentration-dependent effects of AlCl(3) were observed on aggregate size and cell survival. After 24-h exposure to 3 mM AlCl(3), viability of single cells declined from 5% to 3%, while in multicellular aggregates, viability declined from 23% to 20%. The proportion of single cells increased from 30% to 42% within the same concentration range, while in large aggregates, the proportion remained approximately constant representing 35% of the cell suspension. In large aggregates, cell viability (75%) remained unaltered after exposure to AlCl(3) concentrations up to 300 microM, while in single cells, viability was halved at 30 microM. In conclusion, our finding indicates that prolonged exposure to aluminium may lead to significant loss of pituitary cells.

show abstract

Analysis of brain regional distribution of aluminium in rats via oral and intraperitoneal administration

Cited by 55 publications

References 20 publications

The Effect of Aluminum Exposure on Reproductive Ability in the Bank Vole (Myodes glareolus)

The Effect of Aluminum Exposure on Reproductive Ability in the Bank Vole (Myodes glareolus)

Up-regulation in the expression of renin gene by the influence of aluminium

Life and death in aluminium-exposed cultures of rat lactotrophs studied by flow cytometry

Contact Info

Product

Resources

About