Analysis of binary mixtures of flufenamic, meclofenamic and mefenamic acids by derivative synchronous fluorescence spectrometry

Ruiz, T. Pérez; Lozano, C. Martinez; Pérez-Ruíz, Tomás; Carpena, José

doi:10.1016/s0039-9140(98)00086-1

Cited by 53 publications

(15 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Like ACT, overdoses of MEF produce toxic metabolite accumulation that causes acute hepatic necrosis, inducing morbidity and mortality in humans [29]. Several analytical methods include spectrophotometry [30], chromatography [31], chemiluminescence [32], capillary electrophoresis [33], potentiometry [34], polarography [35], and voltammetry [36] methods have been proposed for the determination of mefenamic acid.…”

Section: Introductionmentioning

confidence: 99%

A Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotube/Chitosan Composite as a New Sensor for Simultaneous Determination of Acetaminophen and Mefenamic Acid in Pharmaceutical Preparations and Biological Samples

2010

View full text Add to dashboard Cite

A new chemically modified electrode is constructed based on multiwalled carbon nanotube/chitosan modified glassy carbon electrode (MWCNTs-CHT/GCE) for simultaneous determination of acetaminophen (ACT) and mefenamic acid (MEF) in aqueous buffered media. The measurements were carried out by application of differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CA) methods. Application of DPV method showed that the linear relationship between oxidation peak current and concentration of ACT and MEF were 1 mM to 145 mM, and 4 mM to 200 mM, respectively. The analytical performance of this sensor has been evaluated for detection of ACT and MEF in human serum, human urine and a pharmaceutical preparation with satisfactory results.

show abstract

Section: Introductionmentioning

confidence: 99%

A Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotube/Chitosan Composite as a New Sensor for Simultaneous Determination of Acetaminophen and Mefenamic Acid in Pharmaceutical Preparations and Biological Samples

2010

View full text Add to dashboard Cite

show abstract

“…Overdoses of MEF can lead to toxic metabolite accumulation that causes acute hepatic necrosis, and can result in morbidity and mortality in humans [18]. For this drug analytical methods including spectrophotometry [19], chromatography [20], chemiluminescence [21], capillary electrophoresis [22], potentiometry [23], polarography [24], and voltammetry [25] have been proposed for the determination.…”

Section: Introductionmentioning

confidence: 99%

A new sensor for the simultaneous determination of paracetamol and mefenamic acid in a pharmaceutical preparation and biological samples using copper(II) doped zeolite modified carbon paste electrode

2010

View full text Add to dashboard Cite

A new chemically modified electrode is constructed based on a copper(II) doped zeolite modified carbon paste electrode (Cu 2? Y/ZMCPE). It is demonstrated that this novel sensor could be used for the simultaneous determination of the pharmaceutically important compounds paracetamol (PAR) and mefenamic acid (MEF). The measurements were carried out using the differential pulse voltammetry (DPV) method. The prepared modified electrode shows voltammetric responses of high sensitivity, selectivity and stability for PAR and MEF under optimal conditions, which makes it a suitable sensor for simultaneous submicromolar detection of PAR and MEF in solution. The oxidation peak current for PAR in Briton Robinson buffer (pH = 10) was measured at various concentrations between 0.25 and 900 lM. (The detection limit was 0.1 lM and S/N was 3.) It proved linear (the correlation coefficient was 0.9987). For the MEF a linear correlation between oxidation peak current and concentration of MEF over the range 0.3-100 lM, with a correlation coefficient of 0.9991 and a detection limit of 0.04 lM, was obtained. The analytical performance of this sensor has been evaluated for the detection of PAR and MEF in human serum, human urine and a pharmaceutical preparation.

show abstract

“…These methods include spectrophotometry, [3][4][5] chromatography, [6][7][8][9][10][11] capillary electrophoresis, 12,13 atomic absorption spectrometry, 14 spectrofluorimetry, [15][16][17] derivative synchronous fluorescence spectrometry, 18 high-performance liquid chromatography-mass spectrometry, 19 flow injection analysis, 20 and voltammetry. 21,22 However, many of these methods are often time-consuming, technically demanding and require the use of costly, highly specialized instruments.…”

Section: Introductionmentioning

confidence: 99%

Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analyses

Santini¹,

Pezza²,

Oliveira³

et al. 2008

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

As características, o desempenho e a aplicação de um eletrodo do tipo Pt Hg Hg 2 (FF) 2 Grafite, FF=íon flufenamato, são descritas. O eletrodo responde a FF com sensibilidade de (-58,6 1,2) mV década -1 no intervalo de 1,0 10 -6 -1,0 10 -2 mol L -1 , a pH 6,0 -9,0 e com um limite de detecção de 7,1 10 -7 mol L -1 . O eletrodo é de custo relativamente baixo e facilmente construído, apresenta um rápido tempo de resposta (10-25 s) e pode ser usado por um período de 5 meses sem qualquer variação considerável nas suas características de desempenho. O eletrodo proposto mostrou boa seletividade para o íon flufenamato na presença de várias substâncias, bem como na presença de alguns carboxilatos e ânions inorgânicos. O eletrodo foi aplicado com sucesso na determinação de ácido flufenâmico em medicamentos e amostras de soro humano.The characteristics, performance, and application of an electrode, namely, Pt Hg Hg 2 (FF) 2 Graphite, where FF stands for flufenamate ion, are described. This electrode responds to FF with sensitivity of (-58.6 1.2) mV decade -1 over the range 1.0 10 -6 -1.0 10 -2 mol L -1 at pH 6.0 -9.0 and a detection limit of 7.1 10 -7 mol L -1. The electrode is easily constructed at a relatively low cost with fast response time (within 10-25 s) and can be used for a period of 5 months without any considerable change in its performance characteristics. The proposed electrode displayed good selectivity for flufenamate in the presence of several substances as well as in the presence of some carboxylate and inorganic anions. The electrode was successfully applied to the determination of flufenamic acid in pharmaceuticals and human serum samples.Keywords: flufenamate-sensitive electrode, potentiometry, dosage forms, blood serum IntroductionFlufenamic acid (FFA), [N-( , , -trifluoro-m-tolyl) anthranilic acid] is an analgesic, anti-inflammatory and antipyretic drug. It is extensively used in the treatment of arthritis and other illnesses related to muscular-skeletal problems.1 However the use of this drug has been implicated in some cases of nephrotoxicity.2 Due to the importance of the assay of FFA for pharmaceutical formulations and biological fluids, several analytical methods have been developed for the quantitative determination of this drug in both pharmaceutical and biological samples.These methods include spectrophotometry, 21,22 However, many of these methods are often time-consuming, technically demanding and require the use of costly, highly specialized instruments. Thus, there is an important demand for simple, low-cost, sensitive and rapid alternative methods for the determination of FFA in pharmaceuticals and biological fluids.Potentiometric methods with ion-selective electrodes (ISE's) have proved to be effective for the analysis of pharmaceutical formulations and biological samples, because these sensors offer the advantages of simple design, construction, and manipulation, reasonable selectivity, fast response time, applicability to colored and turbid solutions and possible interfacing with au...

show abstract

Analysis of binary mixtures of flufenamic, meclofenamic and mefenamic acids by derivative synchronous fluorescence spectrometry

Cited by 53 publications

References 24 publications

A Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotube/Chitosan Composite as a New Sensor for Simultaneous Determination of Acetaminophen and Mefenamic Acid in Pharmaceutical Preparations and Biological Samples

A Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotube/Chitosan Composite as a New Sensor for Simultaneous Determination of Acetaminophen and Mefenamic Acid in Pharmaceutical Preparations and Biological Samples

A new sensor for the simultaneous determination of paracetamol and mefenamic acid in a pharmaceutical preparation and biological samples using copper(II) doped zeolite modified carbon paste electrode

Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analyses

Contact Info

Product

Resources

About