A new sensor for the simultaneous determination of paracetamol and mefenamic acid in a pharmaceutical preparation and biological samples using copper(II) doped zeolite modified carbon paste electrode

Abstract

A new chemically modified electrode is constructed based on a copper(II) doped zeolite modified carbon paste electrode (Cu 2? Y/ZMCPE). It is demonstrated that this novel sensor could be used for the simultaneous determination of the pharmaceutically important compounds paracetamol (PAR) and mefenamic acid (MEF). The measurements were carried out using the differential pulse voltammetry (DPV) method. The prepared modified electrode shows voltammetric responses of high sensitivity, selectivity and stability for PAR and MEF under optimal conditions, which makes it a suitable sensor for simultaneous submicromolar detection of PAR and MEF in solution. The oxidation peak current for PAR in Briton Robinson buffer (pH = 10) was measured at various concentrations between 0.25 and 900 lM. (The detection limit was 0.1 lM and S/N was 3.) It proved linear (the correlation coefficient was 0.9987). For the MEF a linear correlation between oxidation peak current and concentration of MEF over the range 0.3-100 lM, with a correlation coefficient of 0.9991 and a detection limit of 0.04 lM, was obtained. The analytical performance of this sensor has been evaluated for the detection of PAR and MEF in human serum, human urine and a pharmaceutical preparation.

Selective determination of mefenamic acid in the presence of 1000-fold excess paracetamol and caffeine using a multiwalled carbon nanotube–polymer composite electrode

“…It can be seen from Table 1, the present method showed the lowest limit of detection for MA when compared to the reported papers. [23][24][25][26][27] For example, the limit of detection of 40 nM was reported at copper (II) doped zeolite modified carbon paste electrode [23] , while 10 nM was reported at MWCNTs-AuNPs-DHP/GC electrode . [24] At RTIL-MWCNTs-CHIT/GC modified electrode, limit of detection of 1.2 µM was reported .…”

Electrooxidation of Zolpidem and its Voltammetric Quantification in Standard and Pharmaceutical Formulation using Pencil Graphite Electrode

“…On the other hand, derivative procedure for GC is difficult to achieve. Electrochemical methods are advantageous in that they are low in cost, rapid, highly sensitive and provide good reproducibility [15][16][17][18][19][20][21][22]. Therefore, the development of an analytical method that is applicable for routine quality control of the active pharmaceutical ingredients is beneficial.…”

Fabrication of electrochemical sensor for paracetamol based on multi-walled carbon nanotubes and chitosan–copper complex by self-assembly technique

“…However, these methods are generally time-consuming and require laborious sample pretreatment. Recently, electrochemical techniques have received tremendous attention on detection of paracetamol due to their merits of high selectivity, simple pretreatment procedure, less time-consuming and low cost [8][9][10][11][12][13][14][15][16].…”