Analysis of 6, 293 Routine Proctosigmoidoscopies

Watanabe, Hikaru; Numazawa, Makoto; Yamagata, Shoichi

doi:10.1620/tjem.119.275

Cited by 9 publications

(3 citation statements)

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“…Through the study of the 470 cases of polyps detected sigmoidoscopically, we have already clarified that the age specific distribution pattern and incidence of adenomas of the large bowel are mostly consistent with those of cancer of the large bowel (Watanabe et al 1976a). When early cancer of the colon and rectum is defined as in early gastric cancer, cancer-containing adenomas comprised the majority (Watanabe et al 1976b;Watanabe 1978).…”

Section: Discussionmentioning

confidence: 91%

Diagnosis of Early Cancer of the Colon and Rectum

Watanabe

Numazawa

Shoji

et al. 1979

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 91%

Diagnosis of Early Cancer of the Colon and Rectum

Watanabe

Numazawa

Shoji

et al. 1979

Tohoku J. Exp. Med.

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“…We have previously reported that most early colorectal cancers are cancercontaining adenomas which present adenoma at non-cancerous part, and that the age distributions are nearly identical for colorectal cancer and adenoma cases (Watanabe et al 1976(Watanabe et al , 1979. These findings suggest that colorectal cancer and adenoma are closely related, probably induced by the same environmental factors.…”

mentioning

confidence: 73%

HLA antigens in colorectal cancers and adenomas.

Hiwatashi¹,

Kikuchi²,

Masamune³

et al. 1980

Tohoku J. Exp. Med.

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and GOTO, Y. HLA Antigens in Colorectal Cancers and Adenomas. Tohoku J. exp. Med., 1980, 131 (3), 257-260-An investigation was made of the differences between colorectal cancer and adenoma using HLA markers.Subjects included 60 cases of colorectal cancer, 43 of colorectal adenoma and 120 healthy Japanese controls.In comparison with the controls, Bw40 was increased (p<0.02) and B5 was decreased (p<0.005) in the colorectal adenoma cases, whereas in the colorectal cancer cases, Bw35 was increased (p<0.005).B5 was significantly less frequent in the adenoma cases than in the cancer cases (p<0.05).It is suggested that the susceptibility of Bw35 to the causal factors of colorectal cancer is under genetic control.HLA antigens; colorectal cancer; colorectal adenomaIt is thought that most colorectal cancers originate as colorectal adenomas. We have previously reported that most early colorectal cancers are cancercontaining adenomas which present adenoma at non-cancerous part, and that the age distributions are nearly identical for colorectal cancer and adenoma cases (Watanabe et al. 1976(Watanabe et al. , 1979. These findings suggest that colorectal cancer and adenoma are closely related, probably induced by the same environmental factors. Nevertheless, studies of the long-term course of adenoma show that most adenomas do not develop into cancers, suggesting that there may be differences in the genetic factors between adenomas which ultimately become malignant and those which do not. Here we report the results of an investigation of the HLA antigen profiles of these lesions. SUBJECTS AND METHODSSubjects included 60 cases of cancer (35 of the colon and 25 of the rectum), 43 adenoma cases (13 of the colon and 30 of the rectum) and 120 normal Japanese as controls.HLA typing was made by means of the microdroplet lymphocyte cytotoxicity test (Mittal et al. 1968). Anti-sera were obtained from Behring Institute, Bosei Co. and Dr.

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“…This prevalence was far higher than that reported by Watanabe et al . [ 25 ] (57 cases of melanosis coli in 6,293 persons undergoing routine proctosigmoidscopy). It is generally recognized that melanosis coli are observed in elderly persons who have a history of chronic laxative use [ 26 – 28 ].…”

Section: Discussionmentioning

confidence: 99%

Endoscopic and Histological Features of the Large Intestine in Patients with Atopic Dermatitis

Arisawa

Yokoi

et al. 2007

J. Clin. Biochem. Nutr.

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Summary Although atopic dermatitis is known to be closely associated with food antigens, the actual changes in the gastrointestinal tract have not been clarified. The aim of this study was to investigate the macroscopic and histological features of the large intestine in patients with atopic dermatitis. We studied 15 outpatients who had generalized atopic dermatitis. Eight non-dermatitis subjects of a similar age without inflammatory bowel disease were also enrolled as controls. Total colonoscopy, pathological evaluation of biopsy specimens, and detection of Candida albicans were performed in all subjects. Four patients were re-examined after 6 months of treatment with an antifungal drug. Among the 15 patients with atopic dermatitis, 4 patients had melanosis coli. On pathological examinations, prominent infiltration of eosinophils and fragmentation of granulocyte nuclei were observed. There were no changes after an antifungal therapy. In the patients with melanosis coli, lipofuscin deposits were observed in the lamina propria. Candida albicans was not detected in any of the subjects. In conclusion, patients with atopic dermatitis may have a predisposition to develop chronic inflammation of the large intestine.

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Analysis of 6, 293 Routine Proctosigmoidoscopies

Cited by 9 publications

References 0 publications

Diagnosis of Early Cancer of the Colon and Rectum

Diagnosis of Early Cancer of the Colon and Rectum

HLA antigens in colorectal cancers and adenomas.

Endoscopic and Histological Features of the Large Intestine in Patients with Atopic Dermatitis

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