Analysis, control and augmentation of microcantilever deflections in bio-sensing systems

Khaled, A.-R. A.; Vafai, Kambiz; Yang, Mo; Zhang, X.; Ozkan, Cengiz S.

doi:10.1016/s0925-4005(03)00231-4

Cited by 65 publications

(57 citation statements)

References 13 publications

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“…1-4 and the related experimental conditions [8], the total thermal output of the biolayer in 1 M NaCl buffer solution is 1 nJ, which might be detectable by a micromechanical sensor with an estimated sensitivity of 1 pJ [30]. The cumulative number of bound molecules was simulated by a first-order chemical reaction equation [16]. An exponential function was obtained for the number of bound molecules.…”

Section: Thermal Output Of the Biolayermentioning

confidence: 99%

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A Model for the Hybridization Exothermic Effect in Label-Free Biodetections by a Nanomechanical Cantilever-DNA Chip

2008

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The influence of the hybridization exothermic effect on nanomechanical deflections of DNA chips in label-free biodetections is investigated. First, from the related experimental curves, the thermal variation of the biolayer during the linkage of DNA base pairs is estimated by Breslauer's method and the Langmuir adsorption isotherm. Second, the temperature field of the chip is obtained by the lumped parameter model and the classical Fourier's method. Third, the nanomechanical deflection of the chip is predicted by an alternative model for thermoelastic problems of laminated cantilever beams. The effect of a DNA base sequence on thermal deflection of chips is also investigated. In the case of adiabatic conditions, numerical results show that the theoretical predicted value of 1.5 nm to 2 nm deflection is within the scope of the optical-beam-deflection readout system's accuracy.

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Section: Thermal Output Of the Biolayermentioning

confidence: 99%

“…This phenomenon is frequently referred to as the "bimetallic effect" [16,17]. The biochip is actually a microcantilever-laminated structure made of a single-or double-stranded DNA (ssDNA or dsDNA) biolayer and three non-biolayers.…”

Section: Introductionmentioning

confidence: 99%

A Model for the Hybridization Exothermic Effect in Label-Free Biodetections by a Nanomechanical Cantilever-DNA Chip

2008

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“…Microcantilevers and microbeams have been shown to be efficient and versatile sensors and actuators with applications in a range of areas including communications, biomedicine, biochemistry and others. Although driving mechanisms for sensing and actuating of cantilevers/beams based devices are different for different applications, in most cases they cause [11][12][13] or are caused [14] by the deflection. The magnitude of that deflection then becomes the main detecting (sensors) or forcing (actuators) factor in the microsystem.…”

Section: Development Of Behavioural Models For Microcantilevers and Mmentioning

confidence: 99%

Development of Behavioural Models for Mechanically Loaded Microcantilevers and Beams

Lishchynska¹,

Cordero²,

Slattery³

2005

Analog Integr Circ Sig Process

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From a modelling viewpoint MEMS are very complex structures. The development of full mathematical models is an extremely challenging problem. Some of the methods, assumptions and simplifications commonly used when modelling macroengineering structures may not be applied to real MEMS.Furthermore applying wellknown behavioural models developed for macrostructures to microdevices has proved to be questionable if not inappropriate. Thus alternative approaches need to be used and new models need to be developed. This paper presents mathematical models of mechanical behaviour of micromachined cantilevers and beams on supports under uniform or concentrated load. The models were extracted from finite element simulation data using dimensional analysis.

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“…a vertical force applied perpendicular to the membrane, of which the stress on the edge of the membrane is further transduced with deposited piezoresistors. The use of holes as a stress-concentrating region has been reported to improve sensitivity in piezoresistive silicon cantilevers for scanning probe microscopy applications, as reported in [10][11][12].…”

Section: Introductionmentioning

confidence: 97%

Biomimetic strain-sensing microstructure for improved strain sensor: fabrication results and optical characterization

Wicaksono

Vincent

Pandraud

et al. 2005

J. Micromech. Microeng.

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This paper describes the fabrication, and early optical characterization results of a new biomimetic strain-sensing microstructure. The microstructures were inspired from the campaniform sensillum, a highly sensitive strain sensor found in the exocuticle layer of insects. We investigate the natural strain-sensor characteristics by mimicking some of its simplest structural features. Blind-hole-and membrane-structural features were combined and fabricated as membrane-in-recess microstructure. To investigate the strain-sensing (or strain-amplifying) property of the microstructure, an optical characterization setup was devised based on the interference pattern formed by reflected laser beams from different surfaces of the microstructures. Preliminary qualitative analysis of the results obtained shows unsimilar intensity level changes as a function of spatial location on the membrane, thus indicated the biomimetic microstructure's strain-amplifying property. This property could be utilized for future improvement of currently available planar-based conventional strain sensors.

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Analysis, control and augmentation of microcantilever deflections in bio-sensing systems

Cited by 65 publications

References 13 publications

A Model for the Hybridization Exothermic Effect in Label-Free Biodetections by a Nanomechanical Cantilever-DNA Chip

A Model for the Hybridization Exothermic Effect in Label-Free Biodetections by a Nanomechanical Cantilever-DNA Chip

Development of Behavioural Models for Mechanically Loaded Microcantilevers and Beams

Biomimetic strain-sensing microstructure for improved strain sensor: fabrication results and optical characterization

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