Análise da frequência de micronúcleos em sangue periférico de mães no período Pós-natal

Mororó, Laiane Silva; Melo, Anna Beatriz da Silva Sousa; Salazar, Érica Rayanne da Silva; Leal, Ruanna Cardoso; Costa, Ana Carla Marques da

doi:10.34119/bjhrv2n6-079

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Micronuclei (MN) were quantified in order to analyze the mutagenic effect. MN analysis makes it possible to identify any increase in the frequency of mutations in cells exposed to genotoxic agents (Mororo, Melo, Salazar, Leal, & Costa, 2019). As MN, the analysis of chromosomal alterations serves as a mutagenicity test (Bagatini, Silva, & Tedesco, 2007) and allows the evaluation of clastogenic and aneugenic actions (Leme & Marin-Morales, 2009).…”

Section: Allium Cepa Bioassaymentioning

confidence: 99%

Evaluation of the cytotoxic and mutagenic potential of Rosmarinus officinalis L. essential oil through the Allium cepa Leach bioassay

Cosme

Nunes

Oliveira

et al. 2022

Acta Sci. Biol. Sci.

View full text Add to dashboard Cite

The species Rosmarinus officinalis L. (rosemary) is an herb from the Lamiaceae family, widely used in cooking as a food preservative, seasoning or condiment. It also stands out for its therapeutic properties, mainly presenting antioxidant, antibacterial and antitumor activity. The aim of this study was to evaluate the cytotoxic and mutagenic activity of R. officinalis L. essential oil through the Allium cepa bioassay. This test constitutes an excellent plant model routinely used due to its sensitivity, low cost and good correlation with test systems in mammals. The defined concentrations for carrying out the test were 750, 243, 81 and 27 µg mL-1. Five bulbs were used, 4 roots of each, measuring approximately 2 cm, and they were analyzed on two slides. All assays were performed at least in triplicate and compared to the negative control. The statistical test of analysis of variance (ANOVA with a fixed factor) was used, followed by Tukey's multiple comparisons test, for p < 0.05. For this purpose, the GraphPad Prism program (version 6.0) was used. The results showed a cytotoxic and mutagenic effect for all concentrations used of the essential oil of R. officinalis L. However, it is important to conduct further research using other genotoxicological tests with different endpoints and at different concentrations, in order to clarify the interaction of the essential oil of the species R. officinalis L. with the genetic material of the cell and its possible mechanism of action.

show abstract

Section: Allium Cepa Bioassaymentioning

confidence: 99%

Evaluation of the cytotoxic and mutagenic potential of Rosmarinus officinalis L. essential oil through the Allium cepa Leach bioassay

Cosme

Nunes

Oliveira

et al. 2022

Acta Sci. Biol. Sci.

View full text Add to dashboard Cite

show abstract

Análise da frequência de micronúcleos em sangue periférico de mães no período Pós-natal

Abstract: Análise da frequência de micronúcleos em sangue periférico de mães no período Pós-natal/ Frequency analysis of micronuclees in main peripheral blood in the Post Christmas period

Cited by 1 publication

References 0 publications

Evaluation of the cytotoxic and mutagenic potential of Rosmarinus officinalis L. essential oil through the Allium cepa Leach bioassay

Evaluation of the cytotoxic and mutagenic potential of Rosmarinus officinalis L. essential oil through the Allium cepa Leach bioassay

Contact Info

Product

Resources

About