Analgesic Effect and Immunomodulation Response on Pro-Inflammatory Cytokines Production by &lt;i&gt;Scrophularia megalantha&lt;/i&gt; Extract

Azadmehr, Abbas; Sofiabadi, Mohammad; Hajiaghaee, Reza

doi:10.4314/tjpr.v12i6.11

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…The late phase seems to be dependent on the combination of an inflammatory pain which arises from the spinal neuro-hyperactivity reaction in the peripheral tissue and function changes in the dorsal horn of the spinal cord, which seems to be initiated by C-fibre barrage [48,49]. Centrally acting drugs show the gracious response in both phases (acute and delayed phase) whereas peripherally acting drugs act only in the late phase [50]. In this study, both doses (200 and 400 mg/kg) of MHAL and EAHAL were worked on both acute and late phase and showed antinociceptive activity by inhibiting inflammatory mediators.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory, antinociceptive and antidiarrhoeal activities of methanol and ethyl acetate extract of Hemigraphis alternata leaves in mice

Rahman¹,

Atikullah²,

Islam³

et al. 2019

Clin Phytosci

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Background: The study was designed to investigate the qualitative phytochemical constituents and evaluate the anti-inflammatory, anti-nociceptive and anti-diarrhoeal activities of methanol (MHAL) and ethyl acetate (EAHAL) extract of Hemigraphis alternata leaves in Swiss albino mice. Methods: Qualitative phytochemical constituents of MHAL and EAHAL were determined by different tests such as Molisch's test, Fehling test, Mayer's test, Frothing test, FeCl 3 test, Alkali test, Salkowski's test, Keller-killiani test and CuSO 4 test. In addition, Xylene induced-ear edema test and Cotton pellet-induced granuloma formation test had been performed to evaluate the anti-inflammatory activity. Moreover, Formalin-induced paw licking test, Acetic acid-induced writhing tests and Castor oil induced antidiarrheal test had been performed to evaluate the antinociceptive and anti-diarrhoeal activities respectively. Results: These crude extracts were figured the presence of carbohydrates, flavonoids, tannins, glycosides, triterpenoids, fat and fixed oils. No mortality, behavioral changes or sign of any toxicity were observed up to the dose as high as 4000 mg/kg in mice. During anti-inflammatory test, MHAL 400 mg/kg and EAHAL 200 mg/kg & 400 mg/kg were significantly reduced ear weight differences and granuloma formation in mice. Highest percentage inhibition was offered by EAHAL 400 mg/kg dose (35.15 ± 11.78% and 34.76 ± 11.30%) in both anti-inflammatory tests respectively. In anti-nociceptive experiments, all extracts were significantly reduced paw licking and abdominal writhing of mice. Highest percentage inhibition was offered by EAHAL 400 mg/kg dose (88.21 ± 2.23% and 54.00 ± 2.38%) in both anti-nociceptive tests respectively. In addition, both extracts were showed significant inhibition of percentage of diarrhea in anti-diarrhoeal models except EAHAL 200 mg/kg dose and the apex percentage inhibition is offered by MHAL 400 mg/kg dose (67.73 ± 5.77%). Conclusion: These results confirm that the leaves extract of Hemigraphis alternata are nontoxic and may provide a source of plant compounds with anti-inflammatory, anti-nociceptive and anti-diarrhoeal activities.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory, antinociceptive and antidiarrhoeal activities of methanol and ethyl acetate extract of Hemigraphis alternata leaves in mice

Rahman¹,

Atikullah²,

Islam³

et al. 2019

Clin Phytosci

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“…The late phase shows inflammatory pain which arises from the spinal neuro-hyperactivity involving various mediators which are started by the C-fibers. Peripherally acting drugs act only on the late phase but centrally acting drugs show good response in both phases [16, 43, 44]. The results of the formalin test stated that PSDE and PSNH work on late phase and inhibit inflammatory mediators, whereas in acute phase PSNH 400 mg/kg showed significant inhibition.…”

Section: Discussionmentioning

confidence: 99%

Analgesic and Anti‐Inflammatory Activities of Diethyl Ether and n‐Hexane Extract of Polyalthia suberosa Leaves

Yasmen

Aziz

Tajmim

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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In folk medicine, Polyalthia suberosa is used as abortifacient, laxative, febrifuge analgesic, filler of tooth cavities, and anti-HIV drug and for rheumatism and various skin infections. The present study was directed to evaluate the analgesic and anti-inflammatory activities of diethyl ether and n-hexane extracts of Polyalthia suberosa leaves (PSDE and PSNH). A variety of tests including formalin-induced paw licking test, acetic acid induced writhing test, and tail immersion test were used to assess the analgesic activity. In addition, xylene-induced ear edema test was used to evaluate anti-inflammatory activity of PSDE and PSNH. PSDE and PSNH at 200 and 400 mg/kg doses expressed analgesic as well as anti-inflammatory activities in mice. In formalin-induced paw licking test, acetic acid induced writhing test, and xylene-induced ear edema test, the extracts exhibited significant inhibition (⁎P < 0.05 versus control) of pain and inflammation. Alternatively, in tail immersion test, PSDE 400 mg/kg showed significant (⁎P < 0.05 versus control) latency at 30 min but another tested sample had no significant latency. From this study, it could be shown that Polyalthia suberosa leaves may contain analgesic and anti-inflammatory agents which support its use in traditional medicine.

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Immunomodulatory effect of Wedelia chinensis and demethylwedelolactone by interfering with various inflammatory mediators

Maji

Mahapatra

Banerji

et al. 2015

Orient Pharm Exp Med

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Analgesic Effect and Immunomodulation Response on Pro-Inflammatory Cytokines Production by <i>Scrophularia megalantha</i> Extract

Cited by 6 publications

References 16 publications

Anti-inflammatory, antinociceptive and antidiarrhoeal activities of methanol and ethyl acetate extract of Hemigraphis alternata leaves in mice

Anti-inflammatory, antinociceptive and antidiarrhoeal activities of methanol and ethyl acetate extract of Hemigraphis alternata leaves in mice

Analgesic and Anti‐Inflammatory Activities of Diethyl Ether and n‐Hexane Extract of Polyalthia suberosa Leaves

Immunomodulatory effect of Wedelia chinensis and demethylwedelolactone by interfering with various inflammatory mediators

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