Analgesic, antipyretic, anti-inflammatory effects of methanol, chloroform and ether extracts of Vernonia cinerea less leaf

Iwalewa, E. O.; Iwalewa, OE; Adeboye, J. O.

doi:10.1016/s0378-8741(03)00081-3

Cited by 101 publications

(58 citation statements)

References 14 publications

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“…In summary, our study confirms the pharmacological % viability = OD product − OD negative control OD positive control X 100 anti-inflammatory activity (Iwalewa et al, 2003). Another study showed a good antiplasmodial activity of vernolide C and D molecules against W2 .…”

Section: Resultssupporting

confidence: 82%

Antiplasmodial activity of Vernonia cinerea Less (Asteraceae), a plant used in traditional medicine in Burkina Faso to treat malaria

Soma¹,

Sanon²,

GansanÃ³

et al. 2017

Afr. J. Pharm. Pharmacol.

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Research and development of new antiplasmodial molecules in plant is a very important way for the development of new anti-malarial drugs. In this study, Vernonia cinerea Less (Asteraceae) was selected for its promising antiplasmodial activity because it is traditionally used in Burkina Faso to treat malaria. The aim of this study was to investigate the antiplasmodial activity of this whole plant. Five crude extracts of V. cinerea Less were prepared from the solvents of increasing polarity (CH 2 Cl 2 , CH 3 OH, CH 3 OH/H 2 O (1/1), H 2 O and alkaloids extracts). The method of Ciulei (1982) and thin layer chromatography were used for chemical characterization. The p-LDH technique was used in vitro. Extracts were evaluated in vitro for efficacy against the Plasmodium falciparum strain K1, which is resistant to chloroquine, and 3D7, which is sensitive to chloroquine. The crude extracts of alkaloids showed the IC 50 =4.25 μg/ml with the strains 3D7 and IC 50 =2.56 µg/ml with the K1 strains. The CH 2 Cl 2 extracts showed the IC 50 = 8.42 µg/ml and IC 50 =5.85 µg/ml on strains 3D7 and K1, respectively. The CH 3 OH extracts showed the IC 50 =21.08 µg/ml, CH 3 OH/H 2 O extracts gave 41.56 µg/ml and H 2 O extracts gave 37.17 µg/ml on strains of P. falciparum K1. The present study highlighted the very promising antiplasmodial activity of V. cinerea Less. The most antiplasmodial activity of this plant extracts merit further study about its in vivo antiplasmodial activity in Plasmodium berghei infected mice.

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Section: Resultssupporting

confidence: 82%

Antiplasmodial activity of Vernonia cinerea Less (Asteraceae), a plant used in traditional medicine in Burkina Faso to treat malaria

Soma¹,

Sanon²,

GansanÃ³

et al. 2017

Afr. J. Pharm. Pharmacol.

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show abstract

“…Besides these, the plant is used in smoking cessation, cough, fever, malaria, urinary calculi, arthritis and leprosy 12,13,14,15 . The plant possesses antimicrobial 16 , antibacterial 17 , antioxidant 18 , antihelmentic, antiinflammatory, analgesic, antipyretic 17,19,20 , antiflautulent, antispasmodic 8 and antidiuretic properties 21 . Some of the phytochemical compounds that have been reported on the plant include: sterols, flavonoids, sesquiterpene lactones 22 and a terpenoid, 'leupeol acetate' which show antihyperglycaemic and antiulcer properties…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and antimicrobial activities of solvent fractions of Vernonia cinerea (L.) Less leaf extract

Sonibare¹,

Aremu²,

Okorie³

2016

Afr H. Sci.

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Background: Vernonia cinerea (L.) Less is used in folk medicine as a remedy for various diseases. Objectives: The present study reports antioxidant and antimicrobial activities of solvent fractions of Vernonia cinerea. Methods: The antioxidant properties of solvent fractions of V. cinerea were evaluated by determining radicals scavenging activity, total flavonoid and phenolic contents measured with the 2,2-diphenyl-1-picryl hydrazyl (DPPH) test, the aluminum chloride and the Folin-ciocalteau methods, respectively. Antimicrobial activities were tested against human pathogenic microorganisms using agar diffusion method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of each active extract were determined. Results: The ethyl acetate fraction having the IC 50 value of 6.50 µg/mL demonstrated comparable DPPH radical-scavenging activity with standard antioxidants, gallic acid and quercetin included in the study. All fractions displayed moderate antimicrobial potential against the tested pathogens with the zone of inhibition that ranged from 9.0 to 13.5 mm. The MIC (1.56 mg/mL) and MBC (3.13 mg/mL) indicated highest susceptibility of Candida albicans in all fractions. Conclusion:The results of this study showed that the solvent fractions of V. cinerea possess antioxidant and antimicrobial activities, hence justifying the folkloric use of the plant for the treatment of various ailments in traditional medicine.

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“…Similarly, the root extract of Solanum incanum (Linneaus) demonstrated antipyretic activity on lipopolysaccharidesinduced pyrexia in male Wistar rats [27]. Besides, according to [28] the methanolic leaf extract of Vernonia cineral showed antipyretic activity on brewer's yeast induced pyrexia in Wistar rats.…”

Section: Discussionmentioning

confidence: 99%

Antipyretic Properties of Methanol Stem Bark Extracts of Acacia hockii De Wild and Kigelia africana (Lam) Benth in Wistar Rats

JK¹,

PM²

2016

J Pharmacogn Nat Prod

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Analgesic, antipyretic, anti-inflammatory effects of methanol, chloroform and ether extracts of Vernonia cinerea less leaf

Cited by 101 publications

References 14 publications

Antiplasmodial activity of Vernonia cinerea Less (Asteraceae), a plant used in traditional medicine in Burkina Faso to treat malaria

Antiplasmodial activity of Vernonia cinerea Less (Asteraceae), a plant used in traditional medicine in Burkina Faso to treat malaria

Antioxidant and antimicrobial activities of solvent fractions of Vernonia cinerea (L.) Less leaf extract

Antipyretic Properties of Methanol Stem Bark Extracts of Acacia hockii De Wild and Kigelia africana (Lam) Benth in Wistar Rats

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