Analgesic, Anti-pyretic and Anti-inflammatory Activity of Dietary Sesame Oil in Experimental Animal Models

Saleem, Tayyaba; Basha, S. Darbar; Mahesh, Gajanuru Basappa; Rani, Priyanka; Kumar, N. Suresh; Chetty, C. Madhusudhana

doi:10.5567/pharmacologia.2011.172.177

Cited by 26 publications

(19 citation statements)

References 5 publications

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“…Diclofenac showed maximum anti-inflammatory activity at 2 and 3 h for the low (5 mg/kg) and high doses (20 mg/kg), respectively, and maintained the activity until the last time point analyzed. These findings are in line with the available literature suggesting the effects of diclofenac in late phase (2–6 h) of inflammatory response [6–11]. …”

Section: Discussionsupporting

confidence: 92%

“…Suitability of this model in terms of assessment of diclofenac anti-inflammatory activity as well as possibility to increase diclofenac-induced anti-inflammatory response or maintain its efficacy but with reduction of adverts effects has been the subject of several experiments [2–11]. Also, diclofenac and/or its metabolites were shown to have a tendency for reaching higher concentration in inflamed footpads in the carrageenan-injected animals [28] inhibiting COX activity.…”

Section: Discussionmentioning

confidence: 99%

“…Due to adverse effects, diclofenac should be used in at the lowest dose and for the shortest term possible [1]. Thus, many attempts were made to develop an approach of combining diclofenac with different agents which could increase sensitivity to diclofenac and decrease its dose [2–11]. …”

Section: Introductionmentioning

confidence: 99%

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RETRACTED ARTICLE: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model

Sakat

Mani

Demidchenko³

et al. 2013

Inflammation

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The study was aimed to investigate the effect of technologically treated diclofenac (release-active dilutions of diclofenac (RAD of diclofenac)) on anti-inflammatory activity of diclofenac in carrageenan-induced rat paw edema model. Ninety male Wistar albino rats (6–8 weeks) divided into nine groups (n = 10) were used. Anti-inflammatory activity was assessed at 1, 2, 3, 4, and 6 h after subplantar injection of carrageenan (0.1 ml of a 1 % solution in normal saline). Diclofenac alone was studied at 5 and 20 mg/kg, RAD of diclofenac alone at 7.5 ml/kg and their combination at 5 and 7.5 ml/kg, respectively. Diclofenac reduced (p < 0.05 at least) paw edema at all time points. RAD of diclofenac enhanced (p < 0.05) anti-inflammatory effect of diclofenac (5 mg/kg) at 2, 4, and 6 h on concurrent and at 2 and 4 h on sequential administration. Moreover at 2 h, anti-inflammatory effect of combination treatment reached values comparable to those of diclofenac (20 mg/kg). In conclusion, RAD of diclofenac enhanced anti-inflammatory effect of diclofenac.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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RETRACTED ARTICLE: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model

Sakat

Mani

Demidchenko³

et al. 2013

Inflammation

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“…In earlier studies it has been recognized that formaldehyde causes synovial fibroblast overgrowth leading to synovial hyperplasia, pannus formation, discharge of various factors that prop up inflammation, neovascularization, cartilage and joint tissue obliteration as seen in rheumatoid arthritis (Saleem et al, 2011). Thus, C. orientalis has potential antiarthritic activity as affirmed by results of formaldehyde induced arthritis.…”

Section: Discussionmentioning

confidence: 85%

Antiarthritic efficacy of Clematis orientalis

Hasan

Alamgeer

2018

Bangladesh J Pharmacol

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Clematis orientalis has been used traditionally to cure rheumatism, but its efficacy has not been scientifically explored in treating rheumatoid arthritis. The present study was designed to investigate the antiarthritic efficacy of C. orientalis using blockade of heat-induced protein alterations and HRBC membrane stabilization methods along with formaldehyde induced arthritis in rats. Aqueous ethanol (30:70) extract and various fractions (hexane, n-butanol and aqueous) produced concentration-dependent and significant (p<0.001) inhibition of protein (egg albumin and bovine serum albumin) denaturation and red blood cell membrane stabilization at 50-6400 ug/mL concentration. Similarly in formaldehyde induced arthritis plant extract and fractions revealed the considerable reduction in paw swelling and its diameter at doses of 50, 100 and 200 mg/kg with maximum (p<0.001) effect at the highest dose. Thus present findings imply that aqueous ethanol extract as well as different fractions of C. orientalis has noteworthy antiarthritic potential supporting its folkloric use in inflammatory arthritic conditions.

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“…[22] Sesame oil is botanically known as S. indicum used as analgesic, antipyretic, and anti-inflammatory activities in animal models. [23] Sesamin, a secondary metabolite, decreases cholesterol levels as well as increases high-density lipoprotein levels. [24] Sesame is a naturally available antibacterial agent for common pathogens of skin and common skin fungal infections like athlete's foot.…”

Section: Introductionmentioning

confidence: 99%

Antifungal properties of soleshine - An in vitro study

Nagesh¹,

Muthuchamy²,

Kannan³

et al. 2018

Natl J Physiol Pharm Pharmacol

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Background: Soleshine is a polyherbal formulation meant to be used to heal cracks on heels, protecting sole from chaffs, marketed by Rumi Herbal Pvt Ltd., Chennai. The active ingriedients are Azadirachta indica, Lawsonia alba, Shorea robusta, Ricinus communis, and Sesamum indicum, which were well known for their antimicrobial activity. Aim and Objectives: The aim of this study is to evaluate the antifungal activity of the ingredients and to evaluate the synergistic activity present in the preparation. Materials and Methods: The plant materials were procured, dried, powdered, and sequentially extracted. The organisms were collected and evaluated the antifungal activity with disc diffusion method for all individual extracts and in combination of different extracts. Sabouraud dextrose agar, culture medium was used for the growth of fungal organism. The minimum inhibitory activity was observed with resazurin method. Clotrimazole, an antifungal drug, belongs to azole group was taken as a standard negative control. Results: The zone of inhibition was determined by disc diffusion method where it shows the inhibition of growth of fungal organism. The same experiment was repeated totally for 6 times and analyzed with SPSS software in May 2017, found that significant (P < 0.05). The minimum amount of extract required to inhibit the growth was determined by resazurin dye method where the color change (oxidation-reduction reaction) implies the viability of fungi. Conclusion: The formulation has an antifungal activity in all the extracts and maximum activity was with aqueous extract, and also, it shows synergistic activity in combination which quotes the additive effect.

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Analgesic, Anti-pyretic and Anti-inflammatory Activity of Dietary Sesame Oil in Experimental Animal Models

Cited by 26 publications

References 5 publications

RETRACTED ARTICLE: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model

RETRACTED ARTICLE: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model

Antiarthritic efficacy of Clematis orientalis

Antifungal properties of soleshine - An in vitro study

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