Antiarthritic efficacy of Clematis orientalis

Hasan, Umme Habiba; Alamgeer, -

doi:10.3329/bjp.v13i2.33313

Cited by 9 publications

(3 citation statements)

References 12 publications

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“…The utmost activity was noticed for chloroform extract of root at 500 μ g/ml (63.28 ± 5.96%). The inclusion of flavonoids and phenolic chemicals, which have previously been shown by several researchers, is thought to be responsible for the crude extracts' antiarthritic effect [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical and Pharmacological Profiling of Heritiera fomes Buch. Ham. Deciphered Thrombolytic, Antiarthritic, Anthelmintic, and Insecticidal Potentialities via In Vitro Approach

Ripa

Hossain

Nesa

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Medicinal plants have been crucial in treating various chronic ailments since ancient times. The objective of this study was to evaluate in vitro pharmacological properties of petroleum ether, chloroform, and ethyl acetate soluble fractions of ethanolic extract (leaf, bark, and root) of Heritiera fomes Buch. Ham., including the phytochemical screening of the plant. Thrombolytic and antiarthritic properties were assessed through the clot lysis and protein denaturation experimental method, correspondingly. Anthelmintic and insecticidal activities were studied against Pheretima posthuma and Tribolium castaneum, respectively. The phytochemical analysis exhibited numerous active phytochemicals in different solvent fractions. In thrombolytic investigation, among all crude extracts, ethanolic leaf extract showed the highest 33.12 ± 7.52% clot lysis as compared to standard streptokinase (67.77 ± 9.78%). In antiarthritic assay, all the tested samples exhibited noteworthy protein denaturation in dose-dependent manner (100–500 μg/mL), whereas the utmost percentage inhibition was noticed for chloroform extract of roots (63.28 ± 5.96% at 500 μg/mL). All crude extracts exhibited a significant anthelmintic activity in different concentrations (25–75 mg/mL) and revealed paralysis and death of earthworms in comparison with albendazole; ethanolic extract of the bark was found to be more potent at the highest dose. For the insecticidal test, ethanolic extract of the leaf showed the utmost mortality rate (73%). The outcomes of the investigation confirmed the potential thrombolytic, antiarthritic, anthelmintic, and insecticidal activities of the different extracts of H. fomes, and hence, advanced studies on the isolation and identification of active phytocompounds are highly needed for new drug development.

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Section: Discussionmentioning

confidence: 99%

Phytochemical and Pharmacological Profiling of Heritiera fomes Buch. Ham. Deciphered Thrombolytic, Antiarthritic, Anthelmintic, and Insecticidal Potentialities via In Vitro Approach

Ripa

Hossain

Nesa

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…The HPLC analysis identified different phenolic and flavonoid contents like catechin, ferulic acid, quercetin, gallic acid, caffeic acid and vanilic acid. It was previously reported that the presence of compounds like ferulic acid, quercetin, gallic acid and vanilic acid was responsible for antioxidant and anti-inflammatory potential [ 33 ]. The presence of these compounds in CT extract had also previously been reported [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Anti-Arthritic Potential of Caralluma tuberculata N. E. Brown. and Its Chemical Characterization

et al. 2022

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Present research was planned to assess the in vitro and in vivo anti-arthritic potential of Caralluma tuberculata N. E. Brown. methanolic (CTME) and aqueous (CTAQ) extracts. Chemical characterization was done by high-performance liquid chromatography and gas chromatography–mass spectrometry analysis. The Complete Freund’s Adjuvant (CFA) was injected in left hind paw of rat at day 1 and dosing at 150, 300 and 600 mg/kg was started on the 8th day via oral gavage in all groups except normal and disease control rats (which were given distilled water), whereas methotrexate (intraperitoneal; 1 mg/kg/mL) was administered to standard control. The CTME and CTAQ exerted significant (p < 0.01–0.0001) in vitro anti-arthritic action. Both extracts notably reduced paw edema, and restored weight loss, immune organs weight, arthritic score, RBCs, ESR, platelet count, rheumatoid factor (RF), C-reactive protein, and WBCs in treated rats. The plant extracts showed significant (p < 0.05–0.0001) downregulation of tumor necrosis factor-α, Interleukin-6, -1β, NF-κB, and cyclooxygenase-2, while notably upregulated IL-4, IL-10, I-κBα in contrast to disease control rats. The plant extracts noticeably (p < 0.001–0.0001) restored the superoxide dismutase and catalase activities and MDA levels in treated rats. Both extracts exhibited significant anti-arthritic potential. The promising potential was exhibited by both extracts probably due to phenolic, and flavonoids compounds.

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“…Nature is ever-giving, rich in beneficial natural products, and never depleted (Elisha et al, 2016). Herbal drugs are promising natural alternatives (Hasan and Alamgeer, 2018). Antiarthritic activity of herbal drugs can be tested through the method “protein denaturation assay” using the Sakat et al’s (2010) method.…”

Section: Introductionmentioning

confidence: 99%

Antihistaminic, Antiarthritic, and Antiobesity Activities of Yellow Horn Poppy Natural Products

Ashour,

Soomro

2024

Pharmacognosy Magazine

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Background: Yellow horn poppy ( Glaucium flavum, syn. Chelidonium flavum) in the family Papaveraceae, is growing in many geographical areas; it is mostly native to Northern Africa, Western Asia, and Europe. The plant is well known for its different types of alkaloids, including aporphines, protopines, and phenolic compounds. In Eastern Europe, the HCl and HBr salts of glaucine (the common active constituent in G. flavum) have been approved as cough suppressants, in addition to several therapeutic applications in traditional medicine. The natural products of G. flavum varied according to the geographical habitat, the stage of maturity, and the selected plant organ. Materials and Methods: For the first time, the extraction and isolation of natural products (alkaloids and flavonoids) from dried aerial parts of the Libyan population of yellow horn poppy and testing their biological effects, which include antihistaminic, antiarthritic, and antiobesity effects. Results: Alkaloids (glaucine and isoboldine) and flavonoid constituents (quercetin-7- O-rutinoside and rutin) have been isolated, while the biological activity results showed that quercetin-7- O-rutinoside and rutin showed half-maximal inhibitory concentration (IC50) (µg) = 29.7 and 46.6, 26.2 and 61.3, and 58.8 and 50.1 for antihistaminic, antiarthritic, and antiobesity, respectively, compared with those of glaucine and isoboldine effects, IC50 = 77.4 and 159.3, 61.7 and 118.7, and 237.8 and 157.6, respectively. Conclusion: According to the obtained results, the antihistaminic, antiarthritic, and antiobesity effects of the flavonoid compounds were stronger than those of the alkaloidal constituents of yellow horn poppy.

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Antiarthritic efficacy of Clematis orientalis

Cited by 9 publications

References 12 publications

Phytochemical and Pharmacological Profiling of Heritiera fomes Buch. Ham. Deciphered Thrombolytic, Antiarthritic, Anthelmintic, and Insecticidal Potentialities via In Vitro Approach

Phytochemical and Pharmacological Profiling of Heritiera fomes Buch. Ham. Deciphered Thrombolytic, Antiarthritic, Anthelmintic, and Insecticidal Potentialities via In Vitro Approach

In Vitro and In Vivo Anti-Arthritic Potential of Caralluma tuberculata N. E. Brown. and Its Chemical Characterization

Antihistaminic, Antiarthritic, and Antiobesity Activities of Yellow Horn Poppy Natural Products

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