Analgesic, Anti-Inflammatory and Anticancer Activities of Extra Virgin Olive Oil

Abstract

Background. In folk medicine, extra virgin olive oil (EVOO) is used as a remedy for a variety of diseases. This study investigates the in vivo antinociceptive, anti-inflammatory, and anti-cancer effects of EVOO on mice and rats. Materials and Methods. In this experimental study, using the acetic acid-induced writhing and formalin tests in mice, the analgesic effect of EVOO was evaluated. Acetylsalicylic acid and morphine were used as standard drugs, respectively. The anti-inflammatory activity was investigated by means of the carrageenan-induced paw edema model in rats using acetylsalicylic acid and dexamethasone as standard drugs. Last, the xenograft model in athymic mice was used to evaluate the anticancer effect in vivo. Results. EVOO significantly decreased acetic acid-induced abdominal writhes and reduces acute and inflammatory pain in the two phases of the formalin test. It has also a better effect than Dexamethasone in the anti-inflammatory test. Finally, the intraperitoneal administration of EVOO affects the growth of HCT 116 tumours xenografted in athymic mice. Conclusion. EVOO has a significant analgesic, anti-inflammatory, and anticancer properties. However, further detailed studies are required to determine the active component responsible for these effects and mechanism pathway.

Synergistic analgesic, anti‐pyretic and anti‐inflammatory effects of extra virgin olive oil and ibuprofen in different experimental models of albino mice

“…The results showed that the intraplantar injection of carrageenan into the mice hind paws induced progressive increase in the edema volume in the positive control as an inflammatory response up to the 4th h, when compared with the negative control group. This observation was coincident with the results of previous studies …”

“…The results of this work revealed that the highest number of writhes was counted in the positive control group. This finding was documented by previous studies . We found also that IBU at a dose of 100 mg/kg significantly decreased the number of writhes.…”

“…Recently the biological properties of EVOO have been widely investigated in many studies, including in vitro , in vivo animal models and in humans. It is well documented nowadays that olive oil especially its phenolic compounds, which nearly account for 36 compounds, have beneficial anti‐inflammatory, antioxidant, anticancer and antimicrobial effects …”

Evaluation of antinociceptive activity of nanoliposome-encapsulated and free-form diclofenac in rats and mice

“…16 The acetic acid-induced writhing test is a sensitive screening assay that is commonly used to study both central and peripheral antinociceptive responses, 27 whereas the formalininduced paw licking test is well established in the elucidation of a compound's mechanism of action at both the peripheral and central levels, where the early phase is characterized by neurogenic pain as a result of direct nociceptors stimulation in the paw and the late phase is characterized by inflammatory pain response due to the release of algogenic substances from damaged tissues. 28 Data obtained from the present study revealed that both liposome-encapsulated and free-form diclofenac exhibited dose-dependent pain inhibitory activities that were characterized by a significant reduction in writhing effect. Further evaluation via the formalin test suggested that liposome-encapsulated diclofenac is more effective in suppressing inflammatory pain and that stronger peripheralmediated antinociceptive activity could be attained using the present liposomal formulations.…”

Review: Germinal Cell Apoptosis by Herbal Medicine

“…europaea contains exogenous antioxidants with various benefits. Olives converted to Extra virgin olive oil (Evoo) possessed analgesic, anti-inflammatory, and anticancer properties [111]. EVOO was reported to able to control the induction of Hsp70 serum levels, thereby reducing growth of cell due to fetal complications in pre-eclampsia [160].…”