Review: Germinal Cell Apoptosis by Herbal Medicine

Situmorang, Putri Cahaya; Ilyas, Syafruddin

doi:10.22159/ajpcr.2018.v11i9.26400

Cited by 8 publications

(8 citation statements)

References 117 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Giving hormones can cause low intratesticular testosterone so that it can induce Fas protein expression in germ cells [22]. Besides of necrosis cells due to this plant, apoptotic process in germ cell can also be triggered by exposing certain plant secondary metabolite to certain cells [23].…”

Section: Discussionmentioning

confidence: 99%

Description of Testis Histology of Mus Musculus After Giving Nano Herbal Rhodomyrtus Tomentosa (Haramonting)

Situmorang

Ilyas

2018

Asian J Pharm Clin Res

Self Cite

View full text Add to dashboard Cite

Objective: The objective of this study was to determine the description of testis histology of male mice (Mus musculus) after giving nano-Rhodomyrtus tomentosa (haramonting).Methods: Leaves of R. tomentosa (haramonting) are made into nanoherbal using high-energy milling, treatment of mice in 14 days, then observation of testis histology, and the data processed with SPSS 22 program with Kruskal–Wallis test. Results: Nano-R. tomentosa administration was not significantly different in weight of testes (p>0.05), but there was significant difference in Spermatogonia, Spermatocytes, and spermatid.Conclusions: Nano-R. tomentosa (haramonting) with excessive doses can cause damage of testis cells, interfere with the process of spermatogenesis, and make infertile.

show abstract

Section: Discussionmentioning

confidence: 99%

Description of Testis Histology of Mus Musculus After Giving Nano Herbal Rhodomyrtus Tomentosa (Haramonting)

Situmorang

Ilyas

2018

Asian J Pharm Clin Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…4). This is due to the presence of antioxidants such as anthocyanins, acylphloroglucinol, flavonoids, tannins, and triterpenes in NRT, which protect cells from hypoxia and death (Situmorang et al, 2021b;Situmorang et al, 2018b).…”

Section: Fas Expressions After Given Nano Herbal R Tomentosa (Nrt) To...mentioning

confidence: 99%

Suppression of Fas expression in the hypertensive placental histology of rast given Nano herbal of Rhodomyrtus tomentosa leaves

Situmorang

Syahputra

Simanullang³

2022

KJS publishes peer-review articles in Mathematics, Computer Sci

View full text Add to dashboard Cite

High blood pressure during pregnancy can signal a high-risk pregnancy and result in difficulties. The expression of Fas is critical for maintaining hypertensive immunity. Fas is prevalent in the trophoblast and enhances maternal-derived apoptosis. Because it contains acylphloroglucinol, flavonoids, tannins, and triterpenes, Rhodomyrtus tomentosa (haramonting) is commonly used in traditional Indonesian medicine to treat high blood pressure. This study aimed to investigate and determine the role of haramonting in lowering Fas expression in hypertensive rats’ placental histopathology. The rats were confirmed to be pregnant and divided into five groups: normal pregnant rats (control); hypertensive rats without treatment; and hypertensive rats given nanoherbal Rhodomyrtus tomentosa (NRT) at different doses: 100 mg/kg body weight (BW), 200 mg/kg BW, and 400 mg/kg BW. On gestation day 20, pregnant rats were euthanized under ketamine anaesthesia. Enzyme-linked immunosorbent assay (ELISA) analysis was used to examine the expression of the HSP family. Immunohistochemistry was used to assess Fas expression. In hypertensive rats, NRT lowered the systolic and diastolic blood pressure (P < 0.01), and NRT improved placental efficiency and restored birth weight. In hypertensive rats, higher doses of NRT were associated with higher levels of HSP27, HSP70, and HSP90. In placental histology, NRT suppresses Fas expression, acting as an anti-apoptotic agent in trophoblast cells. Because NRT is high in antioxidants and protects cells from hypoxia and dehydration, it suppresses Fas activity in the labyrinthine zone, basal zone, and yolk sac.

show abstract

“…Bioactive compounds, such as flavonoid, saponin, and tannin, found in Pirdot leaves stimulate the production of IgG. The ability of saponin can stimulate the cell-mediated immune system in enhancing antibody production [3], [33]. https://www.id-press.eu/mjms/index…”

Section: Measurement Of Igg Activitymentioning

confidence: 99%

“…Lysozymes are ubiquitous enzymes that have specific hydrolytic activity against foreign organisms. Lysozymes are the main factors of innate immunity due to their antibacterial, antiviral, antitumor, and immune modulatory activities [3], [33]. Lysozyme activity is one of the parameters that can measure immunostimulant activity.…”

Section: Effect Of Ees On Lysozyme Activitiesmentioning

confidence: 99%

“…Modern medicine nowadays also uses active compounds isolated from plants that have a potential to treat diseases [2]. Most medicinal plants have been utilized effectively in elevating human immune system [3]. Phytochemicals, such as resveratrol, curcumin, genistein, quercetin, epigallocatechin-3-galate, camptothecin, and 3,3′-diindolymethane, are responsible for plants' immunomodulating properties and allow plants to play a main role in disease prevention [4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Study of extract ethanol of Pirdot (Saurauria Vulcani Korth.) as immunostimulant in Rats (Rattus norvegicus)

Sinaga¹,

Ilyas²,

Hutahaean³

et al. 2020

Open Access Maced J Med Sci

Self Cite

View full text Add to dashboard Cite

BACKGROUND: Ethanolic extract of Pirdot leaves (Saurauria vulcani Korth) (EES) has bioactive compound to decrease glucose and increase insulin levels. AIM: To know of effect of ethanolic extract of Pirdot leaves of immunoglobulin G and lysozyme activity in rats treated with Sheep Red Blood Cell (SRBC). METHODS: Experimental design used in this research was Completely Randomized Design (CRD). There were 24 white rats to be classified into four groups: a control group with water (G0), a group treated with 0.1 ml sheep red blood cell (SRBC) (G1), a group treated with 500 mg/kg ethanol extract pirdot leaves (EES) (G2), and a group treated with 500 mg/KgBW ethanol Extract pirdot leaves (EES) + 0.1 ml SRBC (G3). Immunostimulant activity was evaluated by analyzingthe levels of immunoglobulin G with ELISA method, lysozyme with ABX Micros 60 and histophatology kidney with Hematoxylin-Eosin stainning. RESULTS: The lysozyme activity in rats were treated with only SRBC () is higher and significantly different compared with a group of control (). Necrosis was not found in a group control () and rats treated EES 500 mg/kg ().There were no significant change in histophatology of kidney in rats treated EES 500 mg/kg. Disruption in bowman space with glomerulus was found in G1 (SRBC). Antigen induced disruption in G1 (SRBC) whereas giving extract ethanolic Pirdot leaves concurrently with antigen SRBC can protect kidney from disruption in G3. CONCLUSIONS: A significantly effect of immunoglobulin G, lysozyme activity and histophatology kidney in rats after given by ethanolic extract of pirdot leaves.

show abstract

Review: Germinal Cell Apoptosis by Herbal Medicine

Cited by 8 publications

References 117 publications

Description of Testis Histology of Mus Musculus After Giving Nano Herbal Rhodomyrtus Tomentosa (Haramonting)

Description of Testis Histology of Mus Musculus After Giving Nano Herbal Rhodomyrtus Tomentosa (Haramonting)

Suppression of Fas expression in the hypertensive placental histology of rast given Nano herbal of Rhodomyrtus tomentosa leaves

The Study of extract ethanol of Pirdot (Saurauria Vulcani Korth.) as immunostimulant in Rats (Rattus norvegicus)

Contact Info

Product

Resources

About