Analgesic and antipyretic actions of Muntingia calabura leaves chloroform extract in animal models

Zunita, Z.; Kumar, Gunesh; Zaid, Siti Nh Mohd; Ghani, M. Abdul; Hassan, M. H.; Hazalin, Nurul Amn; Khamis, Mahirah M; Devi, Gokila; Sulaiman, Sulaiman

doi:10.3742/opem.2007.7.1.034

Cited by 10 publications

(12 citation statements)

References 16 publications

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“…The vernacular names of M. calabura in various countries are given in Table 1. This might explain why M. calabura medicinal value is not well documented in Malaysia and why it is considered as a neglected plant (Zakaria et al, 2006a(Zakaria et al, , 2007a. Despite the lack of traditional claims, various parts of the plant have been used to treat different types of illnesses.…”

Section: Traditional Usesmentioning

confidence: 97%

“…A year later, another report on the antinociceptive activity of M. calabura leaves was released (Zakaria et al, 2007a). This time, the leaves were collected between July and August, 2005 from Shah Alam, Selangor, Malaysia, and prepared as CEMC L , in the concentrations of 10, 50, and 100% strength.…”

Section: Antinociceptive Activitymentioning

confidence: 99%

“…The earlier report on anti-inflammatory potential of M. calabura was published by Zakaria et al (2007a). The leaves were prepared as CEMC L , in the concentrations of 10, 50, and 100%, and tested using the carrageenan-induced paw edema test.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…The first attempt to determine the antipyretic potential of M. calabura was made by Zakaria et al (2007a) using the leaves that was prepared as CEMC L . The extract, at the concentrations of 10, 50, and 100%, was tested using Brewer's yeast (BY)-induced pyrexia test.…”

Section: Antipyretic Activitymentioning

confidence: 99%

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Muntingia calabura: A review of its traditional uses, chemical properties, and pharmacological observations

Mahmood

Nasir

Rofiee

et al. 2014

Pharmaceutical Biology

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Context: Different parts of Muntingia calabura L. (Elaeocarpaceae), or ''kerukup siam'' in Malay, have been reported to possess medicinal value, supported by a number of scientific studies. Objective: To gather all information related to the ethnomedicinal uses, phytochemical compositions, and pharmacological activities of M. calabura and present them as a comprehensive and systematic review article. Materials and methods: Literature has been retrieved from a number of databases (e.g., Pubmed, Science Direct, Springer Link, etc.). General web searches were also carried out using Google and Yahoo search engines by applying some related search terms (e.g., Muntingia calabura, phytochemical, pharmacological, extract, and traditional uses). The articles related to agriculture, ecology, and synthetic work and those using languages other than English or Malay have been excluded. The bibliographies of papers relating to the review subject were also searched for further relevant references. Results and discussion: The literature search conducted using the above-mentioned Internet search engines only lead to the identification of 36 journals published as early as 1987. From the articles reviewed, M. calabura possessed various pharmacological activities (e.g., cytotoxic, antinociceptive, antiulcer, anti-inflammatory), which supported the folklore claims and could be attributed to its phytoconstituents. Conclusion: Muntingia calabura possesses remarkable medicinal value, which warrants further and in-depth studies. Therefore, this review paper is presented to help guide researchers to plan their future studies related to this plant in the hope of isolating potential leads for future drug development.

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Section: Traditional Usesmentioning

confidence: 97%

Section: Antinociceptive Activitymentioning

confidence: 99%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Section: Antipyretic Activitymentioning

confidence: 99%

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Muntingia calabura: A review of its traditional uses, chemical properties, and pharmacological observations

Mahmood

Nasir

Rofiee

et al. 2014

Pharmaceutical Biology

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“…A reduction in the writhing number compared to the control group was considered as evidence for the presence of analgesia, which was expressed as percent inhibition of writhing. Data were calculated according to the formula: A -B/A ×100 Where A = mean number of writhes produced by the control groups, and B = mean number of writhes produced by the test groups (Nunez-Guillen et al, 1997;Chattopadhyay et al, 2005b;Zakaria et al, 2007).…”

Section: Acetic Acid-induced Writhing Testmentioning

confidence: 99%

Evaluation of analgesic and antiinflammatory activity of Ophiorrhiza nicobarica, an ethnomedicine from Nicobar Islands, India

Chattopadhyay¹,

Das²,

Mandal³

et al. 2007

Oriental Pharmacy and Experimental Medicine

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SUMMARYThis study reports the analgesic, anti-inflammatory and membrane-stabilizing property of alcoholic extract of Ophiorrhiza nicobarica (ON), a wild herb, used as an anti-infective ethnomedicine of Nicobarese and Shompen tribes of Great Nicobar Island, India. We for the first time investigated the analgesic and antiinflammatory potential of this herb in acute, subacute and chronic model of inflammation in Swiss albino mice and Wistar albino rats, along with sheep RBC-induced sensitivity and membrane stabilization. The acetic acid induced writhing, tail flick and tail immersion tests are used as a model for evaluating analgesic activity; while the carrageenin-induced paw oedema was used as the model for acute inflammation, dextran-induced oedema as sub-acute and cotton-pellateinduced granuloma as chronic inflammatory model. The probable mode by which ON mediate its effect on inflammatory conditions was studied on sheep RBC-induced sensitivity and membrane stabilization. The in vitro results revealed that the ON extract possesses significant (P < 0.05) dose dependent analgesic and antiinflammatory activity at 200 and 300 mg/kg and its fractions at 50 mg/ kg, p.o. respectively, compared to the control groups. However, the extract failed to exhibit membrane-stabilizing property as it unable to reduce the level of haemolysis of RBC exposed to hypotonic solution. The acute toxicity studies of ON extract in rats and mice revealed that the extract was nontoxic even up to 3.0 g/kg body weight of the animals, with a high safety profile. We have isolated ursolic acid, β-sitosterol and harmaline respectively, from the bioactive part of the extract. The results indicated that the O. nicobarica is indeed beneficial in primary health care, and suggest that its anti-inflammatory activity may not be related to membrane-stabilization.

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Muntingia calabura: Chemical Composition, Bioactive Component and Traditional Uses

Mastuki

Faudzi

Ismail

2019

Wild Fruits: Composition, Nutritional Value and Products

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Muntingia calabura, commonly known as Jamaican cherry, is a plant species belonging to the family Muntingiaceae with variety of traditional uses. Following on these folklore claims, the works on phytochemicals constituents, traditional uses, pharmacological benefits and their mechanisms are presented in a number of studies as well as the in vitro and in vivo investigations. This species contains valuable phytochemicals with known medicinal properties that are beneficial to the well-being (e.g. anti-microbial, anti-nociceptive, antiinflammatory etc.). Still, further and in-depth researches including a well-designed pharmacological tests and randomized clinical trials are required to unlock the hidden potential medicinal values of this plant, thus lead to the new drug discoveries of M. calabura.

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Analgesic and antipyretic actions of Muntingia calabura leaves chloroform extract in animal models

Cited by 10 publications

References 16 publications

Muntingia calabura: A review of its traditional uses, chemical properties, and pharmacological observations

Muntingia calabura: A review of its traditional uses, chemical properties, and pharmacological observations

Evaluation of analgesic and antiinflammatory activity of Ophiorrhiza nicobarica, an ethnomedicine from Nicobar Islands, India

Muntingia calabura: Chemical Composition, Bioactive Component and Traditional Uses

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