Analgesic and antiinflammatory activity of Morinda citrifolia L. (Noni) fruit

Abstract

M. citrifolia is a tropical plant with a long tradition of medicinal use in Polynesia and tropical parts of eastern Asia and Australia. One of its favorite uses is the treatment of painful inflammatory conditions, such as arthritis. The analgesic activity of Noni fruit puree on mice was investigated using the hot plate test. A 10% solution of freeze concentrated Noni fruit puree in the drinking water of mice reduced the pain sensitivity comparably to the central analgesic drug tramadol. This effect was only partly reversed by the application of the morphine antagonist naloxone. An alcohol extract of noni fruit puree also caused an inhibition of MMP-9 release from human monocytes after stimulation with LPS. This effect was comparable to hydrocortisone (10(-5) m). The findings suggest that preparations of noni fruits are effective in decreasing pain and joint destruction caused by arthritis.

The Antinociceptive and Anti-inflammatory Action of the CHCl3-Soluble Phase and Its Main Active Component, Damnacanthal, Isolated from the Root of Morinda citrifolia

“…Some researchers have shown that the aqueous extracts of the fruit and roots of the Noni plant have an antinociceptive effect via opioid receptors. 11,12) In the present study, these effects were not inhibited by pretreatment of NLX on the antinociceptive effect of the CHCl 3 -soluble phase. The CHCl 3 -soluble phase may therefore produce an antinociceptive effect without acting on opioid receptors.…”

Morinda Citrifolia (Noni) and Low Dose Aspirin Prevent Apoptotic Cell Death and Oxidative Stress on Isoproterenol Induced Myocardial Infarction in Rats

“…Noni has been reported to possess antithrombotic, antioxidant, analgesic, anti-inflammatory, and xanthine oxidase inhibitory activities (36,37). There are also preliminary studies reporting its blood pressure lowering and vasodilatory properties.…”

Antioxidant and Anti-inflammatory Activities of a Commercial Noni Juice revealed by Carrageenan-induced Paw Edema

“…Noni discovered as a medicinal plant by the ancestors of Polynesians 2000 years ago has been and is still used in traditional medicine, thus being a popular research object. Although first studies on this plant date back to the beginning of 1990s, with two publications in the years of 1907 and 1918 (Simonsen 1920), numerous in vitro and in vivo investigations and clinical trials have started with the advent of noni juice as a health and wellness drink in 1996 and its approval as a novel food by the European Commission in 2003 (Palu et al 2008, Basar et al 2010, Glang et al 2013. Diverse bioactive and therapeutic properties of noni have recently been reviewed by Assi et al (2015), Krishnakumar et al (2015), Motshakeri and Ghazali (2015), Nerurkar et al (2015), and Raja and Sreenivasulu (2015) comprehensively.…”