The Antinociceptive and Anti-inflammatory Action of the CHCl3-Soluble Phase and Its Main Active Component, Damnacanthal, Isolated from the Root of Morinda citrifolia

Okusada, Kanako; Nakamoto, Kazuo; Nishida, Mikako; Fujita-Hamabe, Wakako; Kamiya, Kohei; Mizushina, Yoshiyuki; Satake, Toshiko; Tokuyama, Shogo

doi:10.1248/bpb.34.103

Cited by 23 publications

(17 citation statements)

References 27 publications

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“…This proves that M. citrifolia is having analgesic effect; however, detail studies are necessary for the identification of the chemical compounds and to study the mechanism of action. The analgesic efficacy of alcoholic extracts of Noni fruits was also demonstrated in the acetic acid induced writhing test (Okusada et al, 2011). In another study, Basar et al (2010) demonstrated the analgesic activity of alcohol extract of noni fruit in reducing the pain and arthritis.…”

Section: Analgesic Effectmentioning

confidence: 91%

“…McKoy et al (2002) showed that feeding of 200 mg of M. citrifolia prevented the formation of paw edema in the rats. This anti-inflammatory effect may be due to the inhibition of B2 receptor mediated mechanism of bradykinin Study showed that damnacanthal isolated from the M. citrifolia roots mediates anti-inflammatory activity through H1 receptor (Okusada et al, 2011). Dussossoy et al (2011 reported that the anti-inflammatory activity of the noni is due to the presence of several polyphenols, flavonoids, phenolics compounds, irridoids and ascorbic acid.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

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Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Sunder¹,

Sujatha²,

Kundu³

2016

JEBAS

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KEYWORDS Morinda citrifolia Livestock Poultry Growth Production Immunomodulatory Properties ABSTRACTMorinda citrifolia L. is commonly known as Noni and has been found to have wide range of medicinal properties. It is usually found in the coastal region in many countries including Andaman and Nicobar Islands and belongs to the family Rubiaceae. This small evergreen tree is widely grown and well adapted to the tropics and can grow in fertile, acidic, alkaline and saline affected soils. It tolerates high soil salinity and brackish water stagnation. All the components of this plant have high demand in case of alternative medicines and herbal medicines. Due to its high demand and as a source of revenue generation the detail study on its nutritional benefits and therapeutic values are essential for its commercial exploitation. More than 200 nutraceutical compounds have been identified from the plant. Morinda citrifolia is reported to have broad spectrum biological activities such as antimicrobial, immunomodualtory, antioxidant wound healing etc. Apart from the in-vitro scientific validation of the activities and in-vivo trial in some lab animal model, the plant has been used for livestock and poultry health and production. A lot of reviews have been written on the different uses of Noni, however, scientific review on the use of this plant on the growth, production, immunomodulator and other pharmacological activities of M. citrifolia in livestock and poultry has not been compiled. Therefore this review discusses the compilation of the work done on the use of M. citrifolia in livestock and poultry.

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Section: Analgesic Effectmentioning

confidence: 91%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Sunder¹,

Sujatha²,

Kundu³

2016

JEBAS

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“…It was found that the injection of Carrageenan into the mice paw induced the liberation of bradykinin, which later induced the biosynthesis of PGE2 and other autacoids that are responsible for the formation of the inflammatory exudates [11][12][13][14]. We also evaluated the anti-inflammatory effects of Gardi patch on paw edema induced by Carrageenan in mice and detected the levels of TNF-α and PGE2 the paw edema 0-300 min after Carrageenan injection.…”

Section: Discussionmentioning

confidence: 99%

The Anti-Inflammatory Effect of Gardi Patch in Carrageenan-Induced Paw Edema of Rats

Dejidmaa¹,

Uuganbayar²,

Ch³

et al. 2018

Proc. Mong. Acad. Sci.

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“…This effect maybe produced by a reduction in the levels of histamine, kinins and other inflammatory mediators. The injection of Carr into mice produces a typical biphasic edema related with the formation of numerousin flammatory mediators, including bradykinin, prostaglandins (PGs), NO and 21 cytokines. Development of edema induced by Carr is correlated with the early exudates stage of inflammation, which is one of the important processes of inflammatory pathology.…”

Section: A N T I -I N F L a M M A T O R Y A N D Antinociceptive Activitymentioning

confidence: 99%

A Mini Review on Biological Activities of 6-(4-Chlorophenyoxy)-Tetrazolo [5,1-A] Phthalazine (Quan-0808) Compound

Asif¹

2017

Journal of Pharmaceutical Research

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Abstract:Purpose: Approaches:Findings: Conclusions:Key words:QUAN-0808 (6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine) was tested for the anticonvulsant, anti-inflammatory, analgesic, anticoagulant, antithrombotic and antidepressant effects.Anticonvulsant activity was testedby electroshock seizure model and neurotoxicity was tested by the rotarod neurotoxicity test in mice. In chemically induced models of seizure like pentylenetetrazole, isoniazid, thiosemicarbazide and 3-mercaptopropionic acid were further tested for the anticonvulsant activity.QUAN-0808 caused significant anticonvulsant activity against all types of seizures. It appreciably reduced xylene-induced ear edema, reduced the prostaglandin E2 and nitric oxide levels on the edema and reduced acetic acid-induced capillary permeability hyperactivity and reduced acetic acid-induced writhing response. It exhibited anti-inflammatory and antinociceptiveeffect in a dose-dependent manner.The peripheral effect mechanisms of QUAN-0808 may be related to a reduced in the formation of PGE2, NO, bradykinin and additional inflammatory mediators. The anticoagulant and antithrombotic effects of Q808 delayed bleeding and clotting time in mice. QUAN-0808 exerts anticoagulant, antithrombotic and antidepressant effect, exhibited a significant reduction in immobility as antidepressant. anticonvulsant, antidepressive, antinociceptive, antithrombotic. Tetrazolo

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The Antinociceptive and Anti-inflammatory Action of the CHCl3-Soluble Phase and Its Main Active Component, Damnacanthal, Isolated from the Root of Morinda citrifolia

Cited by 23 publications

References 27 publications

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

The Anti-Inflammatory Effect of Gardi Patch in Carrageenan-Induced Paw Edema of Rats

A Mini Review on Biological Activities of 6-(4-Chlorophenyoxy)-Tetrazolo [5,1-A] Phthalazine (Quan-0808) Compound

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