Analgesic and Anti-inflammatory Effects of Extracts from the Leaves of Markhamia tomentosa (Benth.) K. Schum. (Bignoniaceae)

Temdie, Romeo Joel Guemmogne; Fotio, L.A.; Dimo, Théophile; Beppe, J.G.; Tsague, M.

doi:10.5567/pharmacologia.2012.565.573

Cited by 11 publications

(2 citation statements)

References 16 publications

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“…Moreover, animals received extract treatment during training in the Y-maze and the radial arm-maze tasks. The aqueous extract doses (50 and 200 mg/kg) used in this experiment were chosen since they have been demonstrated by our group to provide significant analgesic and anti-inflammatory effects as claimed by traditional healers [13]. Scopolamine hydrobromide (Sigma-Aldrich, Germany) was dissolved in an isotonic solution (0.9% NaCl) and 0.7 mg/kg scopolamine was injected intraperitoneally (i.p.…”

Section: Methodsmentioning

confidence: 99%

“…commonly known in west Cameroon as “bobedu, abbe or mawelu” is a shrub or tree that belongs to the family Bignoniaceae [13]. Previously, we demonstrated that the methanolic extract of M. tomentosa leaves (50, 100 and 200 mg/kg) possess in vivo analgesic and anti-inflammatory effects in healthy rats and mice as claimed by the traditional practitioners [13]. In addition, we suggested that anti-inflammatory and analgesic effects of the methanolic extract are attributed to the inhibition of serotonin, histamine, prostaglandin and morphinomimetic action.…”

Section: Introductionmentioning

confidence: 99%

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Cognitive-enhancing and antioxidant activities of the aqueous extract from Markhamia tomentosa (Benth.) K. Schum. stem bark in a rat model of scopolamine

et al. 2017

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BackgroundPlants of the genus Markhamia have been traditionally used by different tribes in various parts of West African countries, including Cameroun. Markhamia tomentosa (Benth.) K. Schum. (Bignoniaceae) is used as an antimalarial, anti-inflammatory, analgesic, antioxidant and anti-Alzheimer agent. The current study was undertaken in order to investigate its anti-amnesic and antioxidant potential on scopolamine-induced cognitive impairment and to determine its possible mechanism of action.MethodsRats were pretreated with the aqueous extract (50 and 200 mg/kg, p.o.), for 10 days, and received a single injection of scopolamine (0.7 mg/kg, i.p.) before training in Y-maze and radial arm-maze tests. The biochemical parameters in the rat hippocampus were also assessed to explore oxidative status. Statistical analyses were performed using two-way ANOVA followed by Tukey’s post hoc test. F values for which p < 0.05 were regarded as statistically significant.ResultsIn the scopolamine-treated rats, the aqueous extract improved memory in behavioral tests and decreased the oxidative stress in the rat hippocampus. Also, the aqueous extract exhibited anti-acetylcholinesterase activity.ConclusionsThese results suggest that the aqueous extract ameliorates scopolamine-induced spatial memory impairment by attenuation of the oxidative stress in the rat hippocampus.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cognitive-enhancing and antioxidant activities of the aqueous extract from Markhamia tomentosa (Benth.) K. Schum. stem bark in a rat model of scopolamine

et al. 2017

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Phytochemical screening and in vivo antimalarial activity of extracts from three medicinal plants used in malaria treatment in Nigeria

et al. 2015

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The use of plant to meet health-care needs has greatly increased worldwide in the recent times. The search for new plant-derived bioactive agents that can be explored for the treatment of drug-resistant malaria infection is urgently needed. Thus, we evaluated the antimalarial activity of three medicinal plants used in Nigerian folklore for the treatment of malaria infection. A modified Peter’s 4-day suppressive test was used to evaluate the antimalarial activity of the plant extracts in a mouse model of chloroquine-resistant Plasmodium berghei ANKA strain. Animals were treated with 250, 500, or 800 mg/kg of aqueous extract. It was observed that of all the three plants studied, Markhamia tomentosa showed the highest chemosuppression of parasites of 73 % followed by Polyalthia longifolia (53 %) at day 4. All the doses tested were well tolerated. Percentage suppression of parasite growth on day 4 post-infection ranged from 1 to 73 % in mice infected with P. berghei and treated with extracts when compared with chloroquine diphosphate, the standard reference drug which had a chemosuppression of 90 %. The percentage survival of mice that received extract ranged from 0 to 60 % (increased as the dose increases to 800 mg/kg). Phytochemical analysis revealed the presence of tannins, saponins, and phenolic compounds in all the three plants tested.

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Anti-inflammatory activity of Markhamia tomentosa (Benth.) K. Schum. Ex Engl. ethanolic leaf extract

Sowemimo

Samuel

Fageyinbo

2013

Journal of Ethnopharmacology

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Analgesic and Anti-inflammatory Effects of Extracts from the Leaves of Markhamia tomentosa (Benth.) K. Schum. (Bignoniaceae)

Cited by 11 publications

References 16 publications

Cognitive-enhancing and antioxidant activities of the aqueous extract from Markhamia tomentosa (Benth.) K. Schum. stem bark in a rat model of scopolamine

Cognitive-enhancing and antioxidant activities of the aqueous extract from Markhamia tomentosa (Benth.) K. Schum. stem bark in a rat model of scopolamine

Phytochemical screening and in vivo antimalarial activity of extracts from three medicinal plants used in malaria treatment in Nigeria

Anti-inflammatory activity of Markhamia tomentosa (Benth.) K. Schum. Ex Engl. ethanolic leaf extract

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