Cognitive-enhancing and antioxidant activities of the aqueous extract from Markhamia tomentosa (Benth.) K. Schum. stem bark in a rat model of scopolamine

Ionita, Radu; Postu, Paula Alexandra; Beppe, Galba Jean; Mihășan, Marius; Petre, Brînduşa Alina; Hăncianu, Monica; Cioancă, Oana; Hrițcu, Lucian

doi:10.1186/s12993-017-0123-6

Cited by 24 publications

(23 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The biochemical results obtained in this study indicated that COT and 6HLN exhibit an antioxidant profile in the SCOP-induced zebrafish model of AD. Several reports showed that SCOP treatment induces oxidative stress in the brain of zebrafish [ 36 , 37 , 38 , 92 , 93 ] or rodents [ 64 , 96 , 97 , 98 , 99 ]. In a cell line derived from Danio rerio gill tissue, NIC treatment (3–7 mg/L for 12 h) has been shown to induce intracellular ROS generation in a dose-dependent manner [ 100 ].…”

Section: Resultsmentioning

confidence: 99%

Anxiolytic, Promnesic, Anti-Acetylcholinesterase and Antioxidant Effects of Cotinine and 6-Hydroxy-L-Nicotine in Scopolamine-Induced Zebrafish (Danio rerio) Model of Alzheimer’s Disease

et al. 2021

Self Cite

View full text Add to dashboard Cite

Cotinine (COT) and 6-hydroxy-L-nicotine (6HLN) are two nicotinic derivatives that possess cognitive-improving abilities and antioxidant properties in different rodent models of Alzheimer’s disease (AD), eluding the side-effects of nicotine (NIC), the parent molecule. In the current study, we evaluated the impact of COT and 6HLN on memory deterioration, anxiety, and oxidative stress in the scopolamine (SCOP)-induced zebrafish model of AD. For this, COT and 6HLN were acutely administered by immersion to zebrafish that were treated with SCOP before testing. The memory performances were assessed in Y-maze and object discrimination (NOR) tasks, while the anxiety-like behavior was evaluated in the novel tank diving test (NTT). The acetylcholinesterase (AChE) activity and oxidative stress were measured from brain samples. The RT-qPCR analysis was used to evaluate the npy, egr1, bdnf, and nrf2a gene expression. Our data indicated that both COT and 6HLN attenuated the SCOP-induced anxiety-like behavior and memory impairment and reduced the oxidative stress and AChE activity in the brain of zebrafish. Finally, RT-qPCR analysis indicated that COT and 6HLN increased the npy, egr1, bdnf, and nrf2a gene expression. Therefore, COT and 6HLN could be used as tools for improving AD conditions.

show abstract

Section: Resultsmentioning

confidence: 99%

Anxiolytic, Promnesic, Anti-Acetylcholinesterase and Antioxidant Effects of Cotinine and 6-Hydroxy-L-Nicotine in Scopolamine-Induced Zebrafish (Danio rerio) Model of Alzheimer’s Disease

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…In our study, we induced memory impairment by administering the muscarinic acetylcholine receptor antagonist scopolamine or nicotinic acetylcholine receptor antagonist mecamylamine to rats. Scopolamine is reported to inhibit cholinergic functions in the central nervous system and increase the activity of acetylcholinesterase (31,32).…”

Section: Discussionmentioning

confidence: 99%

The effects and mechanisms of the action of galangin on spatial memory in rats

Kılıç¹,

Kaygisiz²,

Aydin³

et al. 2019

BLL

View full text Add to dashboard Cite

BACKGROUND: Galangin, a fl avonoid compound with acetylcholinesterase inhibitory activity, may improve cognitive functions by enhancing cholinergic transmission. OBJECTIVES: We aimed to investigate the effects of galangin on spatial memory impairment in rats. METHODS: The effects of galangin (50 and 100 mg/kg) and reference anti-dementia drug donepezil (1mg/ kg) administrations were examined on memory impairment induced by the muscarinic cholinergic receptor antagonist scopolamine or the nicotinic cholinergic receptor antagonist mecamylamine in the Morris water maze (MWM) test. Hippocampal acetylcholine concentrations were also determined. RESULTS: Galangin 50 and 100 mg/kg signifi cantly decreased the mean distance to platform and increased the time spent in the escape platform quadrant in scopolamine-treated rats. Galangin 100 mg/kg signifi cantly decreased the mean distance to platform and increased the time spent in the escape platform quadrant in mecamylamine-treated rats. The effects of galangin in the MWM were comparable with donepezil. Scopolamine and mecamylamine decreased acetylcholine concentrations, whereas galangin both alone and with mecamylamine or scopolamine administration increased acetylcholine concentrations. CONCLUSION: Galangin improved memory impairment comparable to donepezil and nicotinic and muscarinic receptors may be involved in this effect. Galangin may be considered as a promising fl avonoid in the prevention and treatment of memory impairment in Alzheimer's disease and other dementias (Fig. 7, Ref. 37).

show abstract

“…The same mechanism was suggested for Markhamia tomentosa extract while exposing scopolamine-treated rats to plant aqueous formulations. 109 In this way, it seems that a major mechanism in scopolamine-induced memory impairment reversal exhibited by the tested plant extract may be linked with oxidative stress decrease in several key brain areas such as hippocampus or brain cortex followed by working memory improvement.…”

Section: Some Molecular Aspects Of Plant Extract Components Relevant mentioning

confidence: 93%

Main Plant Extracts’ Active Properties Effective on Scopolamine-Induced Memory Loss

Balmuș

Ciobîcă

2017

Am J Alzheimers Dis Other Demen

View full text Add to dashboard Cite

Alzheimer's disease leads to progressive cognitive function loss, which may impair both intellectual capacities and psychosocial aspects. Although the current knowledge points to a multifactorial character of Alzheimer's disease, the most issued pathological hypothesis remains the cholinergic theory. The main animal model used in cholinergic theory research is the scopolamine-induced memory loss model. Although, in some cases, a temporary symptomatic relief can be obtained through targeting the cholinergic or glutamatergic neurotransmitter systems, no current treatment is able to stop or slow cognitive impairment. Many potentially successful therapies are often blocked by the blood-brain barrier since it exhibits permeability only for several classes of active molecules. However, the plant extracts' active molecules are extremely diverse and heterogeneous regarding the biochemical structure. In this way, many active compounds constituting the recently tested plant extracts may exhibit the same general effect on acetylcholine pathway, but on different molecular ground, which can be successfully used in Alzheimer's disease adjuvant therapy.

show abstract

Cognitive-enhancing and antioxidant activities of the aqueous extract from Markhamia tomentosa (Benth.) K. Schum. stem bark in a rat model of scopolamine

Cited by 24 publications

References 62 publications

Anxiolytic, Promnesic, Anti-Acetylcholinesterase and Antioxidant Effects of Cotinine and 6-Hydroxy-L-Nicotine in Scopolamine-Induced Zebrafish (Danio rerio) Model of Alzheimer’s Disease

Anxiolytic, Promnesic, Anti-Acetylcholinesterase and Antioxidant Effects of Cotinine and 6-Hydroxy-L-Nicotine in Scopolamine-Induced Zebrafish (Danio rerio) Model of Alzheimer’s Disease

The effects and mechanisms of the action of galangin on spatial memory in rats

Main Plant Extracts’ Active Properties Effective on Scopolamine-Induced Memory Loss

Contact Info

Product

Resources

About