Anaerobic Fecal Flora in Healthy Breast-Fed Turkish Babies Born by Different Methods

Torun, Müzeyyen Mamal; Bahar, Hrisi; Gür, Emel; Taştan, Yücel; Alikaşifoğlu, Müjgan; Arvas, Ahmet

doi:10.1006/anae.2002.0415

Cited by 6 publications

(11 citation statements)

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“…As a type of carbohydrate and a complex of some oligosaccharides and proteins or fatty acids, histoblood group antigens (HBGAs) are distributed on the surface of red blood cells, intestinal and respiratory epithelia and can also exist as free antigens in body fluids, such as in saliva, breast milk, and digestive juices. It is produced by adding fucose to the α- (1,2) position of its precursor to produce H antigen, which is catalyzed by α- (1,2) fucosyltransferase. In human beings, two kinds of α- (1,2) fucosyltransferases are known to be involved in the synthesis of these antigens.…”

Section: Discussionmentioning

confidence: 99%

“…It is produced by adding fucose to the α- (1,2) position of its precursor to produce H antigen, which is catalyzed by α- (1,2) fucosyltransferase. In human beings, two kinds of α- (1,2) fucosyltransferases are known to be involved in the synthesis of these antigens. ey are encoded by two different genes, FUT1 and FUT2 genes.…”

Section: Discussionmentioning

confidence: 99%

“…e FUT1 gene mainly determines the antigens on red blood cells, while the FUT2 gene mainly determines the antigens of other mucosal tissues and epithelial cells. Individuals with FUT2 gene-positive under the action of FUT2 gene add fucose on the precursor through α- (1,2) fucosyltransferase to form H antigen. On this basis, A, B, and Lewis antigens are formed in their body fluids and various epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…Neonatal necrotizing enterocolitis (NEC) is an acute abdomen disorder in the neonatal period. It is more common in premature infants, with a fatality rate as high as 50% [1,2]. Most of the surviving children have serious sequelae.…”

Section: Introductionmentioning

confidence: 99%

“…ey are a series of polyglycoprotein substances formed after fucosylation mediated by α- (1,2) fucosyltransferase encoded by the FUT2 gene. She et al have examined paraffin-embedded intestinal specimens from participants and found that the NEC patients showed lower intestinal epithelial fucosylation levels than the control patients [8].…”

Section: Introductionmentioning

confidence: 99%

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A Study on Fucosyltransferase 2 Gene Polymorphism and Secretion Status Related to Neonatal Necrotizing Enterocolitis

2021

Journal of Healthcare Engineering

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Objective. To detect the single nucleotide polymorphism (SNP) of alpha-(1,2) fucosyltransferase 2 gene (FUT2) and the secretion status in the newborns of Chongqing China and explore the relationship between genotype or phenotype of FUT2 and neonatal necrotizing enterocolitis (NEC). Methods. Newborns who were hospitalized in Children’s Hospital of Chongqing Medical University from August 2014 to December 2015 and in line with the inclusion criteria were chosen as the research subjects; 34 cases of them in accordance with the diagnostic criteria of NEC stage II or III were NEC group, and 36 other cases of them were the control group. Total DNA was extracted from oral epithelial cells of patients which were collected with cotton buds. FUT2 SNP genotype was detected by gene sequencing. H antigen was detected with saliva samples by saliva agglutination inhibition test. Related clinical data were collected for analysis. Results. There are three genotypes on the rs1047781 (A385T) allele of the FUT2 encoding sequence: AA, AT, and TT. The number of genotypes AA, AT, and TT in the NEC group was 9 (26.47%), 12 (35.29%), and 13 (38.24%), respectively. In the control group, the number of genotypes AA, AT, and TT was 12 (33.33%), 17 (47.23%), and 7 (19.44%). There were no differences in genotypes between the two groups according to the chi-square test ( P > 0.05 ). There were 22 cases of secretors (64.7%) and 12 cases of nonsecretors (35.3%) in the NEC group. The number of secretors and nonsecretors in the control group was 31 (88.89%) and 5 (11.11%). Statistical difference was found in the phenotype between two groups through the chi-square test ( P < 0.05 ). In addition, no G428A homozygous mutation, which causes nonsecretor phenotype in Caucasians, was seen in all the subjects of this study. Conclusions. These findings indicate that secretion status (nonsecretor) was significantly associated with NEC in Chongqing, China.

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Section: Discussionmentioning

confidence: 99%