Anaerobic and microaerophilic pathogens in the biofilm formation on voice prostheses: A pilot study

Abstract

For the first time, anaerobic and microaerophilic pathogens have been identified as part of the biofilm formation on the surface of voice prostheses. Those pathogens might be responsible for accelerated biofilm formation and reduced lifetime of the voice prostheses.

Oral cavity anaerobic pathogens in biofilm formation on voice prostheses

“…In general, the reported prevalence of oral anaerobic pathogens is comparable with that found in our 2 previous publications . The slightly increased prevalence of P. micra and T. forsythia in the present study can be explained by the evaluation of single cells of a specific bacterium as positive, and because the bacteria can be visualized, detection is more sensitive and reliable than the previously used PCR‐based method.…”

“…Recently, oral anaerobic bacteria have been found in the biofilm on voice prostheses . These pathogens have been identified as playing a major role in the development of periodontitis, which is a chronic inflammatory disease of the tooth‐supporting structures induced by subgingival biofilm formation on the root surface .…”

“…In particular, F. nucleatum plays an important role in dental biofilm formation, because it is regarded as a “bridge bacterium” connecting the early and the late colonizers . Because of the frequent detection of F. nucleatum , a similar “bridge” function in the formation of biofilms on voice prostheses has been suggested …”

Biofilm Formation by Clinical Isolates and Its Relevance to Clinical Infections

“…Vocal prostheses were explanted from 15 patients, most of whom had squamous cell carcinoma (Bertl et al 2012 ). Following sonication, PCRbased detection identifi ed 11 anaerobic and microaerophilic organisms: Porphyromonas gingivalis , Tannerella forsythia , Treponema denticola , Prevotella intermedia , Peptostreptococcus micros , Fusobacterium nucleatum (most common in this series), Eubacterium nodatum , Aggregatibacter actinomycetemcomitans , Campylobacter rectus , Eikenella corrodens and Capnocytophaga sp.…”

Problemlösung bei Stimmrehabilitation mittels Stimmprothesen

“…Tetraplegie [1,29] B i l d u n g v o n K r u s t e n u n d B o r k e n Mediastinitis/Mediastinalabszess [3,16,36] Bildung eines Biofilms/Candidabewuchs [2,18] Schwere lokale Hautinfektion [1] Granulationsgewebe, Webbildung, Bildung einer intramuralen Tasche Ösophagusstriktur [6,31] Prothesendefekt Ileus nach Stimmprotheseningestion [12] Inkarzeration der Prothese intramural in der Ösophaguswand [7] Aspiration der Stimmprothese [4, 5, 8-10, 14, 19, 30, 33] Leckage und Prothesenfehlfunktion bei intrathorakalem Unterdruck [11] Schwere Stimmfistelerweiterung [21,14] Augmentationsmaterialien In der Literatur wird die Verwendung von Eigenfett, Bioplastic ® , Kollagen, Hyaluronsäure, Zymera und GM-CSF (Granulozyten-Makrophagen-Koloniestimulierender Faktor) beschrieben. Die Kollektivgröße in den Falldarstellungen liegt zwischen 1 und 10 Patienten.…”