Anabolic effects of rhIGF‐I/IGFBP‐3 <i>in vivo</i> are influenced by thyroid status

Svanberg, Elisabeth; Healey, Judy; Mascarenhas, Desmond

doi:10.1046/j.1365-2362.2001.00793.x

Cited by 9 publications

(3 citation statements)

References 25 publications

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“…Thus, it issuggested that higher levels of thyroid hormones during young and growing stage in Beetal goats have metabolic regulatory role in growth and development, probably through synergistic action with growth hormone. Moreover, earlier studies have proved that thyroid function is interrelated closely with the growth hormone/insulin-like growth factor-I (IGF-I), consequently, thyroid hormone levels may influence feed intake, which in turn, affects IGF-I levels, and may modify IGF-I concentrations through effects on GH secretion or receptor levels (Nikolič et al, 1997;Svanberg et al, 2001).…”

Section: Resultsmentioning

confidence: 99%

A Study of Thyroid Hormone Levels in Beetal Goats During Different Development Stages

Madan¹,

Kumar²,

Sindhu³

et al. 2019

IJBSM

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Thyroid hormones are the key regulators of mammalian physiological functions. These hormones have been shown to be crucial for growth, development, energy metabolism and reproduction (Eiler, 2005). These hormones are known to be important modulators of developmental processes and general metabolism in mammals (Kaneko et al., 2008). They also play an important role in defense against infection through the modulation of innate immune cell function (Spek et al., 2017). Changes in the concentrations of serum thyroxine (T 4) and tri-iodothyronine (T 3) of sheep in seasonal heat and cold stress have already been investigated (Dhanda et al., 2001). Circadian variation in thyroid hormones levels have also been reported in domestic animals (Nazifi et al., 2008).

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Section: Resultsmentioning

confidence: 99%

A Study of Thyroid Hormone Levels in Beetal Goats During Different Development Stages

Madan¹,

Kumar²,

Sindhu³

et al. 2019

IJBSM

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“…The thyroid hormone axis is closely interrelated with the GH/IGF axis (Svanberg et al, 2001). Thus, thyroid hormone status may influence feed intake, which subsequently affects IGF-I levels, and may modify IGF-I concentrations through effects on GH secretion or receptor levels.…”

Section: Discussionmentioning

confidence: 99%

Periparturient Endocrine and Metabolic Changes in Healthy Cows and in Cows Affected by Mastitis

Nikolić

Kulcsár

Kátai

et al. 2003

Journal of Veterinary Medicine Series A

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Transition from pregnancy to lactation in dairy cows involves considerable metabolic adaptation. Additional stress is incurred during infections such as periparturient mastitis. Multiparous Holstein-Friesian cows kept under normal production conditions (n = 15) were used to evaluate changes in circulating metabolite and hormone concentrations from 5 days before to 5 days after calving. Insulin-like growth factor binding protein (IGFBP) profiles were also monitored. Marked time-related changes were observed for plasma thyroid hormone, IGF, cortisol, insulin, beta-hydroxybutyrate (BHB) and non-esterified fatty acid (NEFA) concentrations but not for plasma leptin. A decrease in IGF-II concentration and maximal intensity of the putative IGFBP-1 band occurred at parturition. When compared with the five healthy cows,low IGF-II levels were prolonged to day 2 post-partum in five cows with Escherichia coli-associated mastitis. However, marked decreases in IGFBP-2 band intensity were evident only in two of the four cases examined. Individual total ligand (IGF-I + IGF-II) concentration and IGFBP pattern prepartum were largely regained 5 days post-partum in all cows. Hormone and metabolite concentrations in the two cows with Staphylococcus aureus-associated mastitis were very similar to those in the five healthy cows. Plasma thyroxine (T4) was lower 2 days prepartum in the cows, which later developed Gram-negative mastitis. Multiregression analysis showed that variance in T4 concentration was significantly and independently associated with triiodothyronine (T3) and IGF-I positively and with cortisol negatively (R2 = 0.648). This study confirms the close inter-relationship between the thyroid hormone and IGF axes in cattle and indicates possible effects of Gram-negative mastitis infection on IGF-II metabolism.

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“…On the other hand thyroid function was reported to interrelate closely with also the GH/insulin-like growth factor-I (IGF-I) axis (Hoshino et al, 1991;Nikolič et al, 1997;Svanberg et al, 2001). us, thyroid hormone status may influence feed intake, which subsequently affects IGF-I levels, and may modify IGF-I concentrations through effects on GH secretion or receptor levels.…”

Section: Basic Physiology Nutritional Factors Influencing Thyroid Fumentioning

confidence: 99%

Clinical endocrinology of thyroid gland function in ruminants

Huszenicza¹,

Kulcsár²,

Rudas³

2002

Vet. Med.

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After briefly introducing the basec steps in production and metabolism of thyroid hormones, the author gives an overview of nutritional, metabolic and disease related factors and endocrine interactions influencing thyroid gland function in ruminants, particularly in the postpartum dairy cow. Involvement of thyroid hormonal regulation of seasonal patterns of reproduction as well as ovarian endocrine function are discussed.Keywords: thyroxin; triiodothyronine; ovary; metabolism; ruminants Abbreviations: 5'D = 5'-deiodinase (syn.: outer-ring deiodinase); 5D = 5-deiodinase (syn.: inner-ring deiodinase); BHB = βOH-butyrate; E 2 = 17β-estradiol; FSH = follicle stimulating hormone; GH = growth hormone; GnRH = gonadotropin releasing hormone; hCG = human chorionic gonadotropin; IGF-I = insulin-like growth factor-I (syn.: somatomedin C); IL = interleukin; LH = luteinizing hormone; mRNA = messenger ribonucleic acid; NEB = negative energy balance; NEFA = non-esterified fatty acids; P 4 = progesterone; PVN = paraventricular nucleus of the hypothalamus; rT 3 = 3,3',5'-triiodothyronine (syn.: reverse-triiodothyronine); T 3 = 3,3',5-triiodothyronine; T 4 = thyroxine; TNFα = tumor necrosis factor-α; TRH = thyrotropin-releasing hormone; TSH = thyroid-stimulating hormone (syn.: thyrotropin)

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Anabolic effects of rhIGF‐I/IGFBP‐3 in vivo are influenced by thyroid status

Abstract: The relationship between endocrine axes is not simple. An improved understanding of the interactions between neuroendocrine systems may facilitate the design of efficient drug regimens in the treatment of diseases such as osteoporosis and muscle wasting.

Cited by 9 publications

References 25 publications

A Study of Thyroid Hormone Levels in Beetal Goats During Different Development Stages

A Study of Thyroid Hormone Levels in Beetal Goats During Different Development Stages

Periparturient Endocrine and Metabolic Changes in Healthy Cows and in Cows Affected by Mastitis

Clinical endocrinology of thyroid gland function in ruminants

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