An unusual pustular eruption in an infant with Down syndrome and a congenital leukemoid reaction

Transient myeloproliferative disorder with vesiculopustular eruption: Early smear is useful for quick diagnosis

“…In rare cases, TMD is accompanied by vesiculopustular eruption. [3][4][5][6][7][8][9][10][11][12][13] We report an infant with DS showing TMD and skin lesions, in whom genetic analyses detected a somatic mutation of GATA-1 197G[T(Glu295Stop).…”

Neonatal vesiculopustular eruption in Down syndrome and transient myeloproliferative disorder: A case report and review of the literature

“…To our knowledge, 23 cases have been published to date (Table ). The clinical presentation is usually a diffuse eruption of erythematous, crusted papules, papulovesicles, and pustules, often with prominent and initial facial involvement (usually the cheeks) that can be distributed over any part of the body (usually the trunk and limbs) and, in rare cases, palms and soles of feet, perineum, and neck . In 25% of cases, the lesions are described in sites of pressure or trauma.…”

Case 19-2003

“…The rash in congenital leukemia is usually a "monomorphous dermal perivascular and interstitial infiltrate of leukemic cells that may extend deeply into the subjacent dermis," 6 giving the skin a bluish, nodular appearance. However, erythroderma and bullous lesions have also been described, 6 and therefore this child's rash may have been a form of leukemia cutis.…”

“…6,12,17 This rash is described as consisting of papules and vesicles, often concentrated on the face, with subsequent spread to the trunk and a tendency to appear at sites of trauma. In one study, 18 the rash was described as initially mimicking erythema toxicum, in a manner similar to that in the case under discussion.…”