An Unusual Occurrence of Uterine Metastases in a Case of Invasive Ductal Breast Carcinoma

Azhar, Musa; Hamdani, Syed Abdul Mannan; Iftikhar, Jhanzeb; Ahmad, Waheed; Mushtaq, Sajid; Awan, Umm-E Kalsoom

doi:10.7759/cureus.19820

Cureus

2021

DOI: 10.7759/cureus.19820

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An Unusual Occurrence of Uterine Metastases in a Case of Invasive Ductal Breast Carcinoma

Musa Azhar¹,

Syed Abdul Mannan Hamdani²,

Jhanzeb Iftikhar³

et al.

Abstract: Breast cancer is the most frequent cancer in women and has a high proclivity for metastasizing, yet it seldom affects gynaecological organs. We present a case of invasive ductal carcinoma of the breast that metastasized to the uterus following initial curative treatment. Our patient was taking tamoxifen, which can induce endometrial hyperplasia and make diagnosis more complicated.

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2023

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Cited by 2 publications

References 14 publications

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Breast cancer metastasis to endometrium: Case report and up-date of literature

Mohsenzadeh¹,

Chehregani²,

Hassan³

et al. 2023

J Gynecol Res Obstet

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Purpose: Cadmium is a heavy metal and is an important part of Diesel Exhaust Particles (DEPs). Cd in high concentrations exhibited detrimental effects and cause also increase the allergenicity of pollen grains. The aim of the research was to study the effects of Cd on the proteins and allergenicity of Petunia hybrida pollens. Methods: Petunia planets were cultured in a greenhouse and treated with various concentrations of Cadmium Chloride (400, 800 & 1200 µmol/L). The pollen was daily collected from the flowers of both experimental and control plants. Pollen extracts were prepared in PBS from control and Cd-treated plants and changes in protein banding profiles were compared by SDS-PAGE. Mice were sensitized by treatment of pollen extracts and AlOH3, as an adjuvant, three times. The allergenicity of pollen extracts was evaluated by skin test and the amount of IgE in the experimental animals. Results: Gel electrophoretic studies revealed that in the Cd-treated pollen grains, two new protein bands, 46 and 51 kDa, were observed that may have allergenicity. Results of serological tests showed the mean of wheal diameter and IgE level in animals that were sensitized to Cadmium chloride-treated pollen grains are more than the control. Conclusion: In recent years pollinosis is increased in polluted areas, especially DEP-polluted areas; the reason may be that Cadmium, as an important part of DEP, acts as an effective agent in the induction of the formation of detoxifying proteins which can also act as new allergens.

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Breast cancer metastasis to endometrium: Case report and up-date of literature

Mohsenzadeh¹,

Chehregani²,

Hassan³

et al. 2023

J Gynecol Res Obstet

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Uterine Metastasis from Carcinoma of Breast – A Systematic Analysis

et al. 2023

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Breast cancer can metastasize to a wide range of organs, but reports about uterine metastases are rare. The current article systematically analyzes 55 patients reported in peer-reviewed literature from 2010–2022 with respect to nine variables, including: [i] age of the patient; [ii] clinical presentation of uterine metastasis; [iii] precise location of metastasis; [iv] primary (breast) cancer histopathology; [v] imaging modality utilized for detection of metastasis; [vi] timing of appearance of metastases: synchronous or metachronous; [vii] immunochemistry markers; [viii] management; and [ix] survival. Uterine metastases may appear in synchronous or metachronous fashion and may be asymptomatic or have symptoms like abnormal vaginal bleeding. Treatment of uterine metastases usually comprises of total abdominal hysterectomy with bilateral salpingo-oophorectomy along with chemotherapy. The long-term prognosis is unclear, but due to the development of metastases in other bodily parts, cases frequently have a poor outcome.

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An Unusual Occurrence of Uterine Metastases in a Case of Invasive Ductal Breast Carcinoma

Cited by 2 publications

References 14 publications

Breast cancer metastasis to endometrium: Case report and up-date of literature

Breast cancer metastasis to endometrium: Case report and up-date of literature

Uterine Metastasis from Carcinoma of Breast – A Systematic Analysis

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