An unusual cutaneous presentation of Hodgkin's disease

Grip, A. De; Schofield, J. B.; Shotton, J. C.

doi:10.1017/s0022215100145153

Cited by 10 publications

(8 citation statements)

References 18 publications

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“…Primary cutaneous HL responded well to radiotherapy and/or surgical excision, and had a better overall prognosis than that of nodal HL at least when sufficient clinical information was available. [7][8][9][10][11] The description of case 3 in Table 1 suggests the alternative diagnosis of lymphomatoid papulosis given a history of mycosis fungoides and the development of recurrent skin lesions. The presence of ReedSternberg-like cells in lesions of type A lymphomatoid papulosis is well established.…”

Section: Discussionmentioning

confidence: 99%

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An Index Case of Cutaneous Hodgkin Lymphoma and Review of the Literature

Huong

Olson

Rippis³

et al. 2016

The American Journal of Dermatopathology

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Hodgkin lymphoma (HL), although a common hematopoietic malignancy, presents as a primary cutaneous form in extraordinarily rare instances. In this study, we present a remarkable case of a 76-year-old woman with a history of bony metastatic breast cancer who developed multiple subcutaneous nodules on the left neck and scalp. A biopsy revealed the histological and immunohistochemical findings of classic HL. She was treated with systemic chemotherapy and quickly achieved disease remission. Five months later, she was alive and without evidence of lymphoma, consistent with our understanding of primary cutaneous HL as an indolent variant of HL.

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Section: Discussionmentioning

confidence: 99%

“…There are only 9 cases reported in the English literature to date, most are anecdotal at best. [7][8][9][10][11] We present an unusual case of primary cutaneous HL in the setting of breast cancer metastasis.…”

Section: Introductionmentioning

confidence: 99%

An Index Case of Cutaneous Hodgkin Lymphoma and Review of the Literature

Huong

Olson

Rippis³

et al. 2016

The American Journal of Dermatopathology

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“…The epidermis is spared in most of the cases. Few reports documented hyperplasic changes followed by ulceration of the epidermis through the course of the disease 5–8,11–31 …”

Section: Discussionmentioning

confidence: 99%

Solitary plaque on the scalp as a primary manifestation of Hodgkin lymphoma: a case report and review of the literature

Khalifeh

Hughey²,

Huang³

et al. 2009

J Cutan Pathol

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Cutaneous Hodgkin lymphoma is infrequent and typically occurs after extensive involvement of the lymph nodes. The condition decreased significantly in incidence in the past two decades, likely owing to the new treatment protocols composed of chemotherapy, radiotherapy and stem cell transplantation. Nevertheless, recognition of this uncommon but significant disease manifestation is important from a prognostic and therapeutic perspective. We are sharing a recent case of Hodgkin lymphoma where the primary presentation appeared as a solitary plaque on the left side of the occipital scalp, clinically suspected to represent a ruptured follicular cyst. The patient underwent excisional biopsy. Histological assessment revealed Hodgkin lymphoma affecting the skin. Radiological studies showed no regional lymphadenopathy. However, two enlarged lymph nodes were identified in the mediastinum and were positron emission tomography avid. The patient underwent systemic treatment without further histopathological examination of these two lymph nodes. Not being clear if these enlarged two lymph nodes were related to his cutaneous disease or not, we cannot be sure if the patient was afflicted either by primary cutaneous Hodgkin lymphoma or by secondary cutaneous involvement because of hematogenous spread. In either case, primary or secondary cutaneous Hodgkin disease is an extreme rarity. The literature is critically reviewed.

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“…2,5 Recently some authors reported sinus and fistula formation, cutaneous vasculitis, erythrema nodosum and ichthyosis in HD. [13][14][15][16] Histologically, in CLHD the lesions show uninvolved epidermis, a diffuse infiltrate of lymphocytes, plasma cells, eosinophils, macrophages and RS cells with prominent eosinophilic nucleoli in the subcutis and reticular dermis. 17 The diagnosis of HD in a skin biopsy should be made cautiously to differentiate it from other neoplastic lesions of the skin simulating cutaneous HD (e.g., lymphomatoid papulosis, anaplastic large cell lymphoma).…”

Section: Discussionmentioning

confidence: 99%