Cutaneous Relapse in Hodgkin’s Disease

Jain, Shyama; Nigam, Sonu; Kumar, Neeta; Reddy, B. Naresh Kumar

doi:10.1159/000326132

Cited by 5 publications

(7 citation statements)

References 10 publications

(6 reference statements)

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“…9,22,24,[36][37][38] Whenever IGH gene rearrangement analysis was performed, we identified an abnormal and clonal B-cell population in association. 24,36 In this report, all three cases showed a clonal B-cell population in Although skin occurrence of cHL is rare and poorly described in the literature, [43][44][45][46][47][48] it has been described in advance stages of the disease and associated with adverse prognosis. 43 Phenotypically, tumor cells harbor the classical morphology and phenotype, strong expression of CD30 and CD15, weak PAX5 expression and lack other B-cell markers.…”

Section: Patientmentioning

confidence: 73%

“…Although skin occurrence of cHL is rare and poorly described in the literature, it has been described in advance stages of the disease and associated with adverse prognosis . cHL cutaneous involvement may occur as a unique cutaneous ulcer, cutaneous nodules or erythematous indurate papules and plaques …”

Section: Discussionmentioning

confidence: 99%

“…,45 cHL cutaneous involvement may occur as a unique cutaneous ulcer, 46,47 cutaneous nodules 48 or erythematous indurate papules and plaques 44. …”

mentioning

confidence: 99%

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Cutaneous localization of angioimmunoblastic T‐cell lymphoma may masquerade as B‐cell lymphoma or classical Hodgkin lymphoma: A histologic diagnostic pitfall

et al. 2018

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Background We report the cases of three patients presenting skin lesions whose biopsies showed nodular polymorphic infiltrates consisting of lymphocytes, plasma cells, histiocytes, eosinophils, B blasts, and Hodgkin Reed‐Sternberg (HRS)‐like cells. Two of them were initially diagnosed as classical Hodgkin lymphoma (cHL), on the other hand, the last one as a B‐cell lymphoma. All patients have been treated for angioimmunoblastic T‐cell lymphoma (AITL). Methods We performed a second review of the skin biopsies with further immunophenotypic molecular analyses. Scrupulous observation revealed, in the background of the three cases, atypical small to medium‐sized lymphocytes carrying a CD3+, CD4+ T‐cell phenotype and expressing PD1 and CXCL13 follicular helper T‐cell markers. The two lesions initially diagnosed as cHL showed scattered HRS‐like cells with CD30+, CD15+, PAX5+, CD20−, Epstein Barr Virus (EBV) + classical phenotype. The case initially diagnosed as B‐cell lymphoma showed a diffuse B‐cell proliferation associated with small B‐cell and medium to large‐sized B blasts that were positive for EBV. Conclusion Those cases highlighted that atypical T‐cells may be obscured by B‐cell proliferation mimicking cHL or B‐cell lymphoma in cutaneous localization of AITL and confirmed the requirement of collecting clinical information before performing a diagnosis.

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Section: Patientmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Cutaneous localization of angioimmunoblastic T‐cell lymphoma may masquerade as B‐cell lymphoma or classical Hodgkin lymphoma: A histologic diagnostic pitfall

et al. 2018

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“…Review of literature corresponding to our 15‐year study period (2000‐2015) revealed 20 reports based either on cases series or isolated cases (Table ) in which 26 histologically confirmed chest wall lymphoma cases were described . Location of the swellings was the anterior chest wall/manubrium in 14 cases, left chest wall (four cases), right chest wall (three cases), lateral chest wall (NOS in two cases), back in one case and rib/chest wall swellings and NOS in two cases.…”

Section: Discussionmentioning

confidence: 99%

“…During the past one and half decades, only two case series of chest wall lymphomas were found in the published literature . On rare occasions fine needle aspiration (FNA) cytology has been utilised as a diagnostic tool for chest wall lymphomas with limited success . Our experience with 11 chest wall lymphoid neoplasms diagnosed during the past 15 years by FNA cytology and review of published literature on this subject is described.…”

Section: Introductionmentioning

confidence: 99%