An Underlying Pathological Mechanism of Meningiomas with Intratumoral Hemorrhage: Undifferentiated Microvessels

Wang, Hongcai; Wang, Boding; Chen, Maosong; Li, Shiwei; Hai, Chen; Xu, Wei; Zhang, Jianmin

doi:10.1016/j.wneu.2016.07.042

Cited by 28 publications

(37 citation statements)

References 25 publications

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“…Various postulations are available for this rare phenomenon: compensatory vascular dilatation, neovascular formation, vascular erosion, intratumoral necrosis, trauma, etc. [1278] The exact etiopathogenesis of bleed in our case is difficult to explain as the lesion proved to be a Grade 1 meningothelial meningioma on histopathology, and such presentation is very rare in the pathology mentioned above. The most likely cause for the ITH in our case may be attributed to the ill-formed new blood vessels which bled or the vascular erosion caused by the tumor.…”

Section: Discussionmentioning

confidence: 77%

Apoplexy inside a giant medial sphenoid wing meningothelial (Grade I) meningioma: An extremely rare but a potentially dangerous complication

et al. 2019

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Hemorrhage associated with meningiomas is extremely rare and most commonly occurs in convexity meningiomas of higher grade or the angioblastic variety. Moreover, bleeding associated with a meningioma usually occurs in the form of a subdural hematoma or subarachnoid hemorrhage. We report a case of giant left medial sphenoid wing meningioma with histopathological diagnosis of a meningothelial type with apoplexy. A 54-year-old female presented with clinical features suggestive of apoplexy. Her neuroimaging demonstrated a large left medial sphenoid wing meningioma with features suggestive of an intratumoral bleed with mass effect. Gross total excision of the tumor was done with the good postoperative outcome. The biopsy came out to be Grade I meningothelial meningioma. Apoplexy in meningiomas is extremely rare with a reported incidence of 0.5%–2.4%, especially in a nonconvexity meningioma with histopathological diagnosis of meningothelial variety. Early diagnosis and prompt surgical intervention are critical as meningiomas associated with apoplexy are associated with high morbidity.

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Section: Discussionmentioning

confidence: 77%

Apoplexy inside a giant medial sphenoid wing meningothelial (Grade I) meningioma: An extremely rare but a potentially dangerous complication

et al. 2019

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“…[ 1 , 2 , 8 ] Nevertheless this still does not explain why this is such a rare event, since most meningiomas we see in our daily practice do not follow this course. [ 15 , 28 ] It is accepted that several mechanisms might simultaneously be involved in the development of hemorrhage. [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

Meningioma-related subacute subdural hematoma: A case report

Matos

Pereira

2020

Surgical Neurology International

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Background: Meningiomas are the most frequent benign head tumors, although spontaneous hemorrhage is a rare form of presentation of such lesions. Of all possible bleeding locations associated with them, the subdural space is one of the most uncommon, with very few cases reported worldwide. Case Description: A middle-aged woman presented with progressively worsening left-sided headache, initiated 2 weeks before, with no other complaints, denying any previous head trauma. Head computed tomography revealed a subacute left hemisphere subdural hematoma and left frontal, suggestive of meningioma on magnetic resonance imaging. Surgical treatment was performed with hematoma evacuation and lesion removal. Neuropathology showed a transitional meningioma with signs of hemorrhage. After surgery, no neurological deficits were registered, and headache abated. Conclusion: As we could not identify any other cause for the subacute subdural hematoma, hemorrhage from the meningioma was the most probable cause, and thus, we decided to remove it along with clot evacuation. Based on neuropathological findings, we propose an alternative mechanism for this spontaneous hemorrhage from the meningioma, involving the place where the periphery of the lesion insertion, the dura mater as the origin of the hemorrhage. Knowledge of this association could help define the best treatment in such cases.

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“…Finally, while the angiomatous, transitional, and meningothelial subtypes have most frequently been reported in cases with hemorrhage [ 4 , 8 ], no statistically significant association to histologic subtype has been proven in the literature [ 2 , 19 ]. A study by Wang et al demonstrated that a greater proportion of CD31+/CD34- undifferentiated blood vessels exist in meningiomas that present with hemorrhage, however, no correlation was found for the number of differentiated vessels or total number of vessels between hemorrhagic and non-hemorrhagic tumors [ 19 ]. Despite the lack of statistical significance with regard to histologic subtype, the case presented herein adds an additional report of angiomatous meningioma presenting with intratumoral hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous or Traumatic Intratumoral Hemorrhage? A Rare Presentation of Parafalcine Meningioma

Dang

Mugge

Awan

et al. 2020

Cureus

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An Underlying Pathological Mechanism of Meningiomas with Intratumoral Hemorrhage: Undifferentiated Microvessels

Cited by 28 publications

References 25 publications

Apoplexy inside a giant medial sphenoid wing meningothelial (Grade I) meningioma: An extremely rare but a potentially dangerous complication

Apoplexy inside a giant medial sphenoid wing meningothelial (Grade I) meningioma: An extremely rare but a potentially dangerous complication

Meningioma-related subacute subdural hematoma: A case report

Spontaneous or Traumatic Intratumoral Hemorrhage? A Rare Presentation of Parafalcine Meningioma

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