An overview of extended-spectrum beta-lactamases in veterinary medicine and their public health consequences

Nobrega, Diego; Brocchi, Marcelo

doi:10.3855/jidc.4704

Cited by 17 publications

(16 citation statements)

References 55 publications

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“…Guidelines for alternative therapies, monitoring programs, and development of preventive medicine will decrease the spread of ESBLs in veterinary medicine. Together, these strategies could certainly reduce the impact of several multidrugs resistance microorganisms on animal health [18].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

CTX-M producing Escherichia coli isolated from cattle feces in Bogor slaughterhouse, Indonesia

Sudarwanto

Lukman

Latif

et al. 2016

Asian Pacific Journal of Tropical Biomedicine

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Objective: To determine the occurrence of CTX-M producing Escherichia coli (E. coli) from cattle feces in Bogor slaughterhouse, Indonesia. Methods: A total of 220 cattle feces samples were collected from Bogor slaughterhouse from March to April 2015. Presence of extended-spectrum beta-lactamase (ESBL) producing E. coli was detected by disc diffusion test based on the recommendation from Clinical and Laboratory Standards Institute (2014). Bacterial strains which were confirmed as producing ESBLs were further analyzed for the presence of bla genes of the ESBL by PCR. Results: The results showed that CTX-M producing E. coli isolates were detected in 19 samples from 220 samples (8.6%). The β-lactamase genes detected were CTX-M-1 (n = 10) and CTX-M-9 (n = 9). All of the CTX-M producing E. coli isolates showed multidrug resistance phenotypes to at least four antibiotics. The highest incidence of antibiotics resistance was showed to ampicillin (100.0%), cefotaxime (100.0%), and cefpodoxime (100.0%), followed by streptomycin (84.3%), trimethoprim-sulfamethoxazole (73.7%), erythromycin (52.6%), kanamycin (26.3%), doxycycline (10.5%), and ceftazidime (0.0%). Conclusions: Detection of CTX-M-producing E. coli in cattle feces raises important questions as they can represent a potential risk factor to public health.

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

CTX-M producing Escherichia coli isolated from cattle feces in Bogor slaughterhouse, Indonesia

Sudarwanto

Lukman

Latif

et al. 2016

Asian Pacific Journal of Tropical Biomedicine

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“…The problem is that the use of antibiotics in animals increases the size of the gene pool to further the emergence of multi-resistant enterococci causing human infections (Bates, 1997). Evidence of potential relationships between the use of animal drugs with resistant bacteria affecting humans have been established by a number of researchers (Alba et al, 2015;Argudín et al, 2015;Feßler et al, 2012;Graveland et al, 2010;Nóbrega and Brocchi, 2014;Schmithausen et al, 2015).…”

Section: The Need For the Vfd: Human Acquired Antibiotic Resistance Fmentioning

confidence: 99%

Recent government regulations in the United States seek to ensure the effectiveness of antibiotics by limiting their agricultural use

Centner

2016

Environment International

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The development of bacteria resistant to antibiotics is viewed as a medical health threat. Because thousands of people die every year due to antibiotic-resistant bacteria, efforts are underway to reduce antibiotic usage which in turn will reduce the development of antibiotic-resistant bacteria. In the United States, the use of antibiotics in the production of food animals to enhance animal growth has been identified as contributing to resistance. In 2015, a veterinary feed directive was adopted by the U.S. federal government prohibiting nontherapeutic uses of antibiotics in food animals that should reduce usage. The continued usage of antibiotics by producers for preventing disease may mean the directive is insufficient to reduce nontherapeutic antibiotic administration. This may lead some consumers to seek meat products from animals raised without antibiotics. A governmentally-sponsored labeling program could encourage reduction in antibiotic usage.

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“…Beta-lactams (penicillins, cephalosporins, carbapenems, and monobactams) constitute the therapy of choice for some well-established practices and infections in veterinary medicine [2]. The third generation of cephalosporins has been associated with the emergence of beta-lactamases mediated bacterial resistance, which subsequently led to the development of extended spectrum beta-lactamase (ESBL)-producing bacteria.…”

Section: Introductionmentioning

confidence: 99%

Study of antimicrobial resistance due to extended spectrum betalactamase-producing Escherichia coli in healthy broilers of Jabalpur

et al. 2016

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Aim:To study the prevalence of antimicrobial resistance due to extended spectrum beta-lactamase (ESBL)-producing Escherichia coli in samples collected from the ceca of healthy broilers of poultry sale outlets (PSOs) Jabalpur.Materials and Methods:A total of 400 cecal swab samples were taken randomly from freshly slaughtered poultry of 39 PSOs located at four different zones or areas of Jabalpur and were screened for the presence of ESBL-producing E. coli using standard methods. Further they were characterized phenotypically by standard methods.Results:All the 400 samples were screened for E. coli producing ESBL enzyme. Among the samples positive for E. coli 135 were positive for ESBL E. coli giving an overall prevalence of 33.5%.Conclusion:This study related to the prevalence of ESBL-producing E. coli in healthy broilers in Jabalpur is indicative of antibiotic resistance prevalent in the healthy birds which are used for human consumption as well. It also signifies resistance prevalent against beta-lactam antibiotics including third and fourth generations of cephalosporins.

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An overview of extended-spectrum beta-lactamases in veterinary medicine and their public health consequences

Cited by 17 publications

References 55 publications

CTX-M producing Escherichia coli isolated from cattle feces in Bogor slaughterhouse, Indonesia

CTX-M producing Escherichia coli isolated from cattle feces in Bogor slaughterhouse, Indonesia

Recent government regulations in the United States seek to ensure the effectiveness of antibiotics by limiting their agricultural use

Study of antimicrobial resistance due to extended spectrum betalactamase-producing Escherichia coli in healthy broilers of Jabalpur

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