An overview of chitosan and its application in infectious diseases

Meng, Qingye; Sun, Yu; Cong, Hailin; Hu, Hao; Xu, Fu‐Jian

doi:10.1007/s13346-021-00913-w

Cited by 54 publications

(29 citation statements)

References 90 publications

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“…During the last decades, HIV infection, hepatitis B and C, were among the most threatening viral infections, determining chronic diseases difficult to be controlled and associated with a high mortality and morbidity [ 74 ]. Nowadays, other viruses are overwhelming the medical community, such as SARS-Cov-2, influenza viruses [ 75 ].…”

Section: Pharmacological Potential Of Chitosan and Its Derivatives Applications In Current Pharmacotherapymentioning

confidence: 99%

Preparation and Antimicrobial Activity of Chitosan and Its Derivatives: A Concise Review

et al. 2021

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Despite the advantages presented by synthetic polymers such as strength and durability, the lack of biodegradability associated with the persistence in the environment for a long time turned the attention of researchers to natural polymers. Being biodegradable, biopolymers proved to be extremely beneficial to the environment. At present, they represent an important class of materials with applications in all economic sectors, but also in medicine. They find applications as absorbers, cosmetics, controlled drug delivery, tissue engineering, etc. Chitosan is one of the natural polymers which raised a strong interest for researchers due to some exceptional properties such as biodegradability, biocompatibility, nontoxicity, non-antigenicity, low-cost and numerous pharmacological properties as antimicrobial, antitumor, antioxidant, antidiabetic, immunoenhancing. In addition to this, the free amino and hydroxyl groups make it susceptible to a series of structural modulations, obtaining some derivatives with different biomedical applications. This review approaches the physico-chemical and pharmacological properties of chitosan and its derivatives, focusing on the antimicrobial potential including mechanism of action, factors that influence the antimicrobial activity and the activity against resistant strains, topics of great interest in the context of the concern raised by the available therapeutic options for infections, especially with resistant strains.

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Section: Pharmacological Potential Of Chitosan and Its Derivatives Applications In Current Pharmacotherapymentioning

confidence: 99%

Preparation and Antimicrobial Activity of Chitosan and Its Derivatives: A Concise Review

et al. 2021

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“…A variety of these strategies have been studied; chitosan-coating of MPs and NPs, chitosan-functionalized systems, encapsulated chitosan, hybrid systems including chitosan, and surface modification of drug delivery systems [8,22,[70][71][72]. Moreover, the preparation method can tailor the properties of chitosan to improve the suitability of formulation for the specific routes of application [8,73].…”

Section: Coating Materials and Excipientsmentioning

confidence: 99%

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

2021

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Chitosan is one of the most studied natural origin polymers for biomedical applications. This review focuses on the potential of chitosan in localized antimicrobial therapy to address the challenges of current rising antimicrobial resistance. Due to its mucoadhesiveness, chitosan offers the opportunity to prolong the formulation residence time at mucosal sites; its wound healing properties open possibilities to utilize chitosan as wound dressings with multitargeted activities and more. We provide an unbiased overview of the state-of-the-art chitosan-based delivery systems categorized by the administration site, addressing the site-related challenges and evaluating the representative formulations. Specifically, we offer an in-depth analysis of the current challenges of the chitosan-based novel delivery systems for skin and vaginal infections, including its formulations optimizations and limitations. A brief overview of chitosan’s potential in treating ocular, buccal and dental, and nasal infections is included. We close the review with remarks on toxicity issues and remaining challenges and perspectives.

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“…Additionally, deacetylation and molecular weight play a crucial role in eliciting biological activity. Chitosan serves as a noninvasive mucosal vaccine vector due to its adhesiveness characteristics (Boroumand et al, 2021;Meng et al, 2021). Chitosan can be an opportunistic approach to fighting against COVID-19 infection.…”

Section: Chitosanmentioning

confidence: 99%

Potential Application of Bionanoparticles to Treat Severe Acute Respiratory Syndrome Coronavirus-2 Infection

Debnath

Srivastava

2022

Front. Nanotechnol.

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a contagious virus that spreads exponentially across the world, resulting in serious viral pneumonia. Several companies and researchers have put their tremendous effort into developing novel vaccines or drugs for the complete eradication of COVID-19 caused by SARS-CoV-2. Bionanotechnology plays a vital role in designing functionalized biocompatible nanoparticulate systems with higher antiviral capabilities. Thus, several nanocarriers have been explored in designing and delivering drugs and vaccines. This problem can be overcome with the intervention of biomaterials or bionanoparticles. The present review describes the comparative analysis of SARS infection and its associated etiological agents. This review also highlighted some nanoparticles that have been explored in the treatment of COVID-19. However, these carriers elicit several problems once they come in contact with biological systems. Often, the body’s immune system treats these nanocarriers as foreign particles and antigens. In contrast, some bionanoparticles are highlighted here with their potential application in SARS-CoV-2. However, bionanoparticles have demonstrated some drawbacks discussed here with the possible outcomes. The scope of bioinspired nanoparticles is also discussed in detail to explore the new era of research. It is highly essential for the effective delivery of these nanoparticles to the target site. For effective management of SARS-CoV-2, different delivery patterns are also discussed here.

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An overview of chitosan and its application in infectious diseases

Cited by 54 publications

References 90 publications

Preparation and Antimicrobial Activity of Chitosan and Its Derivatives: A Concise Review

Preparation and Antimicrobial Activity of Chitosan and Its Derivatives: A Concise Review

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

Potential Application of Bionanoparticles to Treat Severe Acute Respiratory Syndrome Coronavirus-2 Infection

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