An Overview about Biomedical Applications of Micron and Nano Size Tantalum

Maccauro, Giulio; Iommetti, Pierfrancesco Rossi; Muratori, Francesco; Raffaelli, Luca; Manicone, Paolo Francesco; Fabbriciani, C.

doi:10.2174/187220809789389153

Cited by 51 publications

(25 citation statements)

References 69 publications

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“…Tantalum, a metal of noteworthy interest for biomedical applications, especially in orthopedic and dentistry, has high strength, ductility and corrosion resistance with excellent biocompatibility [24,33]. Moreover, tantalum forms a self-passivating surface oxide layer that leads to the formation of a bone-like apatite coating in vivo.…”

Section: Introductionmentioning

confidence: 99%

Development of tantalum scaffold for orthopedic applications produced by space-holder method

et al. 2015

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a b s t r a c tIn the present study, production of tantalum porous scaffolds using the space holder technique was performed. The effect of size and content of sodium chloride particles, used as space holder, as well as compacting pressure on foam structure and mechanical properties have been investigated. The morphological characterization was carried out by means of scanning electron microscopy (SEM), mercury intrusion porosimetry (MIP) and micro-CT technique. The relationship between the elastic modulus and yield strength of the tantalum porous scaffold and the pore structure was evaluated. Space holder technique allows obtaining tantalum open-cell structure (70% of porosity) and modulus of elasticity similar to cancellous bone, with reproducible processability into three-dimensional structures and reasonable manufacturing costs.

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Section: Introductionmentioning

confidence: 99%

Development of tantalum scaffold for orthopedic applications produced by space-holder method

et al. 2015

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“…2 Alumina is also used in dentistry for better aesthetics and reliability of dental repair. 3 Machining of ceramic is often required for the strict requirement of shape and dimensional control and high hardness of ceramics restricts the machining property through conventional techniques. 4 Thus requirement of costly diamond tools makes the machining of ceramics un-economical.…”

Section: Introductionmentioning

confidence: 99%

Reactive alumina–LaPO4 composite as machinable bioceramics

Badolia¹,

Sarkar²,

Pal³

2015

Bull Mater Sci

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Sintered Al 2 O 3-LaPO 4 composites were prepared using commercially available reactive alumina and phase pure lanthanum phosphate (LP), prepared by the reaction synthesis technique. LP content was varied between 10 and 50 wt% and sintering was carried out between 1400 and 1600 • C. Sintered composites were characterized for phase analysis, densification, strength, machinability, microstructure and bioactivity (in SBF solution) and biocompatibility (MTT assay protocol) studies. Composite nature was confirmed by phase analysis and LP was found to reduce the densification and strength values but imparted machinability. Again positive bioactivity and biocompatibility character were observed for all the compositions.

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“…In orthopedic applications, this concept is embodied in the use of porous metal scaffolds for bone repair. 18,19 However, this concept has not been successfully applied in the area of cartilage repair. Our porous nondegradable hydrogel scaffold was designed to function as a cell-free device that would be press-fit into a debrided cartilage defect site, providing initial fill and reinforcement in vivo.…”

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confidence: 99%

A Novel Macroporous Polyvinyl Alcohol Scaffold Promotes Chondrocyte Migration and Interface Formation in anIn VitroCartilage Defect Model

Wanivenhaus

Chen

et al. 2012

Tissue Engineering Part A

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Scaffold-cartilage integration is critical for the clinical success of a scaffold used for the repair of a focal cartilage defect. In this study, a macroporous polyvinyl alcohol (PVA) scaffold was found to facilitate chondrocyte infiltration and interfacial matrix formation in a juvenile bovine in vitro cartilage defect model. These results were found to depend on the press-fit between the scaffold and the cartilage, pretreatment of the cartilage with collagenase prior to scaffold insertion, and chondrocyte preseeding of the scaffold. Infiltrated and preseeded chondrocytes in the scaffold survived for 6 weeks in culture and resulted in sufficient matrix at the interface to significantly increase the interface shear strength 30-fold that compared favorably with the interface shear strength of cartilage-cartilage constructs. The ability of this macroporous PVA scaffold to form a stable interface with articular cartilage demonstrates the potential use of this scaffold design for focal cartilage defect repair.

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An Overview about Biomedical Applications of Micron and Nano Size Tantalum

Cited by 51 publications

References 69 publications

Development of tantalum scaffold for orthopedic applications produced by space-holder method

Development of tantalum scaffold for orthopedic applications produced by space-holder method

Reactive alumina–LaPO4 composite as machinable bioceramics

A Novel Macroporous Polyvinyl Alcohol Scaffold Promotes Chondrocyte Migration and Interface Formation in anIn VitroCartilage Defect Model

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