An overlooked indicator of disease activity in ulcerative colitis: Mean platelet volume

Abstract

Many non-invasive tests have been studied for diagnosis and determining the activation degree of inflammatory bowel disease (IBD). Nevertheless, an ideal test has not been found yet. Mean platelet volume (MPV) is influenced by the inflammation. In a few study, decreased platelet volume have been reported in IBD. The aim of this study is to determine whether platelet volume would be useful in ulcerative colitis (UC) activity. Additionally we have analyzed overall accuracy of MPV in disease activity and compared with other inflammatory markers. A total of 61 UC patients (male/female : 41/20), and 27 healthy subjects (male/female : 18/9) were enrolled into the study. For all subjects following tests were performed; ESR, CRP, white blood cell count and mean platelet volume. A statistically significant decrease in MPV was noted in patients with UC (8.29 +/- 1.02 fL) compared with healthy controls (8.65 +/- 0.79 fL). MPV of active UC (8.06 +/- 1.19 fL) patients were significantly lower than that of inactive UC (8.45 +/- 0.87 fL). Overall accuracy of MPV in determination of active UC was 71% (with sensitivity 67%, specificity 73%). A negative correlation was found between MPV and endoscopic activity index (r : -0.358 p : 0.005). In UC, MPV did not correlate with ESR, CRP and white blood cell. Our study showed that MPV reduced in UC, particularly in patients with active UC. Decreased MPV may be an indicator for increased disease activity in patients with UC.

Mean platelet volume in acute appendicitis: A gender difference

“…Although, MPV is an easily obtainable index from automated hematology analyzers, it has rather been overlooked until its associations with various diseases are continuously being reported recently. MPV is known to be decreased in diseases of acute pancreatitis, ulcerative colitis, rheumatoid arthritis and ankylosing spondylitis [9][10][11] as well as local inflammatory conditions including acute appendicitis (AA) due to migration and consumption of highly reactive large platelets into sites of inflammation [12]. AA is a common surgical emergency requiring timely intervention while its diagnosis can be elusive [13].…”

A review of the association of mean platelet volume and red cell distribution width in inflammation

“…31 Similar results have been published in two reports showed decreased MPV in patients with inflammatory bowel disease compared to healthy subjects. 32,33 Afterwards, relation of decreased MPV with inflammation has been shown in different inflammatory conditions such as rheumatoid arthritis, 34 and nasal polyp. 7 In contrast, some authors reported elevated MPV in inflammatory conditions.…”

Diagnostic Value of Mean Platelet Volume in Acute Appendicitis

“…Mean platelet volume (MPV) is a parameter that is automatically measured when obtaining a complete blood count. In the literature, studies have investigated the relationships between MPV and many diseases such as stroke, myocardial infarction, pulmonary embolus, pancreatitis, diabetes mellitus, cancer, sepsis, hypertensive crisis, ulcerative colitis, ankylosing spondylitis and rheumatoid arthritis [2][3][4][5][6][7][8][9][10][11]. Recently, MPV has been reported to be helpful in the diagnosis of AA [12][13][14][15][16][17].…”