Mean platelet volume in acute appendicitis: A gender difference

Yang, John Jeongseok; Cho, Sun Young; Hyung-jun, Ahn; Lee, Hee Joo; Lee, Wooin; Park, Tae Sung

doi:10.3109/09537104.2013.766923

Cited by 10 publications

(14 citation statements)

References 15 publications

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“…Yang et al stated that the difference in the MPV of AA patients and controls could be affected by gender. In that study, they found a significant difference only among male patients [17]. In our study, we detected no significant difference in MPV in either male or female patients.…”

Section: Discussioncontrasting

confidence: 61%

“…Mean platelet volume is known to be a marker determined from megakaryocytes during platelet production, which is an indicator of platelet function and activation [3,4]. Recent studies have reported that MPV can be used in the diagnosis of AA [12][13][14][15]17]. In our study, we found no significant difference between the MPVs of AA patients and the control group (p=0.193).…”

Section: Discussioncontrasting

confidence: 56%

“…An electronic database (PubMed, Google Scholar, EMBASE) search identified six studies investigating the diagnostic value of MPV in AA. Four studies stated that the MPV was lower in AA patients than in controls, whereas one study reported the opposite finding [12][13][14][15]17]. Furthermore, the sixth study showed no significant difference between the 2 groups [16].…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, studies have investigated the relationships between MPV and many diseases such as stroke, myocardial infarction, pulmonary embolus, pancreatitis, diabetes mellitus, cancer, sepsis, hypertensive crisis, ulcerative colitis, ankylosing spondylitis and rheumatoid arthritis [2][3][4][5][6][7][8][9][10][11]. Recently, MPV has been reported to be helpful in the diagnosis of AA [12][13][14][15][16][17]. In this study, we examined the diagnostic value of MPV for AA.…”

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confidence: 99%

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Diagnostic Value of Mean Platelet Volume in Acute Appendicitis

Kılıç¹

2016

Ann Clin Anal Med

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Anahtar KelimelerOrtalama Trombosit Hacmi; Cerrahi; Akut Apandisit; Acil Servis Abstract Aim: The diagnosis of acute appendicitis for patients referred to the emergency department with the complaint of abdominal pain remains challenging. In this study, we investigated the diagnostic value of mean platelet volume in acute appendicitis. Material and Method: This clinical research study was performed retrospectively and included patients referred to the emergency department between January 1 and December 31, 2013, with the complaint of abdominal pain and were then discharged without a specific diagnosis in comparison to patients with a proven diagnosis of acute appendicitis. Control patients were selected using a randomization method from among patients of the same age and gender as acute appendicitis patients. The acute appendicitis group was subdivided into complicated and noncomplicated cases according to the pathology results. The Mann-Whitney U test for continuous variables and the chi-square test for categorical data were used. Results: This clinical research study was performed with 316 acute appendicitis patients and an equal number of control patients; 188 of the patients were male. Among the acute appendicitis patients, 67 presented with complicated acute appendicitis and 249 with noncomplicated acute appendicitis. The median mean platelet volume of the acute appendicitis versus control patients was 8.03 fL (IQR: 1.86; min: 5.53, max: 14.40) and 8.10 fL (IQR: 1.38; min: 5.70, max: 13.90), respectively (p=0.193). The platelet counts in the complicated and noncomplicated groups were 235 K/µL (IQR: 70; min: 116, max: 649) and 261 K/µL (IQR: 87; min: 124, max: 537), respectively (p<0.001). Discussion: Mean platelet volume is not a useful guide in the diagnosis of acute appendicitis for patients referred to the emergency department with the complaint of abdominal pain.

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Section: Discussioncontrasting

confidence: 61%

Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Diagnostic Value of Mean Platelet Volume in Acute Appendicitis

Kılıç¹

2016

Ann Clin Anal Med

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“…MPV is a reflection of both pro‐inflammatory and prothrombotic conditions and it has been regarded as a prognostic marker of arterial and venous thrombosis . PLTs are highly activated when inflammatory mediators are released and the mean platelet volume (MPV) and platelet distribution width (PDW) are affected in patients with inflammatory and infectious disorders such as rheumatoid arthritis and ankylosing spondylitis . According to literature, psychiatric disorders such as schizophrenia, unipolar depression, and bipolar disorder have abnormal (too low or too high) platelet counts and MPV parameters.…”

Section: Introductionmentioning

confidence: 99%

Alterations of the hematologic cells in synthetic cannabinoid users

Güzel

Yazıcı

et al. 2017

Clinical Laboratory Analysis

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Our data suggested that chronic use of cannabinoids can lead to deterioration of hematopoietic cells. Chronic use of cannabinoids was consistent with subthreshold/subclinical megaloblastic anemia with iron deficiency. Inflammatory cells, especially neutrophil and monocyte counts were higher in SG compared to CG. Thus, recovery of subclinical hematological parameters should be considered in cannabis use disorder patients.

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Mean Platelet Volume and Platelet Distribution Width as Markers in the Diagnosis of Acute Gangrenous Appendicitis

Yingyi

Wang

et al. 2015

Disease Markers

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Introduction. Acute gangrenous appendicitis (AGA) is a common medical condition; however, the grade of appendicitis usually cannot be established preoperatively. We have attempted to identify some indicators, such as the mean platelet volume (MPV) and the platelet distribution width (PDW), to diagnose AGA. Aims. To evaluate whether or not the MPV and PDW are suitable markers to diagnose AGA. Methods. A retrospective study of 160 patients with AGA and 160 healthy patients was undertaken. Disease diagnosis was confirmed based on the pathologic examination of surgical specimens. Patient white blood cell (WBC) count, neutrophil ratio (NR), platelet (PLT) count, MPV, PDW, and hematocrit (HCT) were analyzed. Receiver operating characteristic (ROC) curves were used to evaluate the sensitivity and specificity of these indices in AGA. Results. There were no significant differences between the AGA and control groups in age and gender. Compared to the control group, the WBC count, NR, and PDW were significantly higher (P < 0.001, resp.) and the MPV and HCT were significantly lower (P < 0.001, resp.) in the AGA group. The diagnostic specificities of the WBC count, NR, PLT count, MPV, PDW, and HCT were 86.3%, 92.5%, 58.1%, 81.7%, 83.9%, and 66.3%, respectively. Therefore, the NR had the highest diagnostic specificity for the diagnosis of AGA. Conclusions. This is the first study to assess the MPV and PDW in patients with AGA. Our present study showed that the MPV is reduced and the PDW is increased in patients with AGA; the sensitivity of PDW was superior to the MPV. A decreased MPV value and an increased PDW could serve as two markers to diagnose AGA. The NR had the highest specificity for the diagnosis of AGA.

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Mean platelet volume in acute appendicitis: A gender difference

Cited by 10 publications

References 15 publications

Diagnostic Value of Mean Platelet Volume in Acute Appendicitis

Diagnostic Value of Mean Platelet Volume in Acute Appendicitis

Alterations of the hematologic cells in synthetic cannabinoid users

Mean Platelet Volume and Platelet Distribution Width as Markers in the Diagnosis of Acute Gangrenous Appendicitis

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