An outbreak of Aujeszky's disease in sheep in Northern Ireland

Henderson, J; Da, Graham; Stewart, D. F.

doi:10.1136/vr.136.22.555

Cited by 15 publications

(14 citation statements)

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“…In Borna disease, lesions mainly involve the frontal and olfactory cortex, basal ganglia and hippocampus. Descriptions of the histopathology and other aspects of these diseases can be found in Maxie and Youssef (2007) and in Vandevelde et al (2012), as well as specifically for louping ill in (Doherty and Reid, 1971;González et al, 1987;Sheahan et al, 2002), for rabies in Perl and Good (1991) and Suja et al (2011), for Aujeszky's disease in Dow andMcFerran (1964, 1966;Schmidt et al, 1992) and Henderson et al (1995) and for Borna disease in Richt et al (1997), Stitz et al (1995) and Wahlenkamp et al (2002).…”

Section: Post-natal Infections By Neurotropic Virusesmentioning

confidence: 96%

Diagnostic pathology in microbial diseases of sheep or goats

Benavides

González

Dagleish

et al. 2015

Veterinary Microbiology

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Post-mortem examination is a key step in the diagnostic process of infectious diseases in sheep and goats. Diagnostic pathology deals with identification and study of lesions, at the same time providing also significant clues regarding pathogenesis of the diseases. This article reviews the salient pathological findings associated with the most significant infectious diseases of sheep and goats present in countries where small ruminants are a relevant agricultural industry. Lesions are reviewed according to the different organ systems where they occur. Emphasis has been given in the description of the salient lesional patterns than can be identified in each organ and which can be of help in the differential diagnosis of the lesions caused by bacteria, viruses, fungi or prions. Finally, a review of the usefulness of ancillary tests that may be used on various tissue samples for performing an aetiological diagnosis, is included; the application of various techniques, from immunohistochemistry to molecular biology-based tests, is described.

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Section: Post-natal Infections By Neurotropic Virusesmentioning

confidence: 96%

Diagnostic pathology in microbial diseases of sheep or goats

Benavides

González

Dagleish

et al. 2015

Veterinary Microbiology

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“…Aujeszky's disease is caused by the Pseudorabies virus (PRV) (Mettenleiter, 2000) with domestic pigs and wild boar as principal hosts (Christensen et al, 1993;Ruiz-Fons et al, 2008). Outbreaks have occurred in countries including Denmark, Germany, Ireland, Poland, the United Kingdom, and the United States (Christensen et al, 1993;Gloster et al, 1984;Henderson et al, 1995;Müller et al, 2003;Obaldía, 2005;Salwa, 2004;Scheidt et al, 1991).…”

Section: Pseudorabies Virusmentioning

confidence: 99%

Atmospheric dispersion modelling of bioaerosols that are pathogenic to humans and livestock – A review to inform risk assessment studies

Leuken

Swart

Havelaar

et al. 2016

Microbial Risk Analysis

121

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“…Although the air-borne transmission of PRV, even over long distances, is possible between swine [ 40 , 41 ], it has not been reported in dogs. An early report suggested that sheep, another unnatural host, are probably infected through skin abrasions [ 42 ]. Therefore, it is possible that contact with contaminated garbage or food through an injured alimentary tract is a possible route of infection in dogs.…”

Section: Discussionmentioning

confidence: 99%

Pathogenesis of natural and experimental Pseudorabies virus infections in dogs

Zhang

Zhong

Wang

et al. 2015

Virol J

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BackgroundSince late 2011, cases of suspected canine pseudorabies have increased in north China with the outbreak of swine pseudorabies in the same area, but the pathogenesis of canine Pseudorabies virus (PRV) infections in China is poorly understood. In this study, we investigated the pathogenesis of canine pseudorabies.MethodsThe pathological changes in 13 dogs that died of natural PRV infections (confirmed by pathogen detection) during 2011–2013 in Beijing were evaluated. An experimental study was also conducted in which healthy adult beagle dogs were administered PRV isolate BJ-YT by subcutaneous injection. The dog tissues were subjected to gross and microscopic examinations and immunohistochemical analysis and the dogs’ serum cardiac troponin-I (cTn-I) was measured.ResultsSystemic hemorrhage and/or congestion were the most marked pathological changes in both the naturally and experimentally PRV-infected dogs. Macroscopically, the major lesions consisted of petechiae and ecchymoses in both the endocardium and epicardium, thrombi in the mitral valves, hemorrhage in the lungs and thymus, and incomplete contraction of the spleen. Microscopically, the major histopathological findings were systemic hemorrhage and congestion, nonsuppurative ganglioneuritis (in the experimentally infected dogs, unexamined in the naturally PRV-infected dogs), brainstem encephalitis (in the naturally infected dogs), necrosis or exudation in the myocardium, and lymphoid depletion in many lymphoid organs and tissues. Viral antigens were only detected in the brainstems and peripheral ganglia of the infected dogs. Serum cTn-I was significantly higher in the experimentally PRV-infected dogs with myocardial lesions than in the dogs without myocardial lesions.ConclusionsBased on these results, we conclude that virally induced systemic hemorrhage, peripheral nervous system pathology, and/or cardiac injury can individually or collectively cause death in PRV-infected dogs. The respiratory signs of the disease are attributed to cardiogenic lesions.

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An outbreak of Aujeszky's disease in sheep in Northern Ireland

Cited by 15 publications

References 0 publications

Diagnostic pathology in microbial diseases of sheep or goats

Diagnostic pathology in microbial diseases of sheep or goats

Atmospheric dispersion modelling of bioaerosols that are pathogenic to humans and livestock – A review to inform risk assessment studies

Pathogenesis of natural and experimental Pseudorabies virus infections in dogs

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